Breast cancer in young women: clinicopathological features and biological specificity

Sidoni, Angelo; Cavaliere, Antonio; Bellezza, Guido; Scheibel, Massimo; Bucciarelli, E

doi:10.1016/s0960-9776(03)00095-x

Cited by 116 publications

(95 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is believed that factors like young age and poor differentiation of triple negative cancers contribute to their aggressive nature (Mersin et al, 2008;Kwan et al, 2009;Dawood et al, 2010). These factors have been shown to be independent predictors of outcome in breast cancer patients (Adami et al, 1986;Chung et al, 1996;Sidoni et al, 2003;Sharif et al, 2010). Lack of effectiveness of hormonal therapy limits the medical options available for management of TNBC.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Triple-Negative Versus Non-Triple-Negative Breast Cancers Managed with Breast-Conserving Therapy

Bhatti

Khan

Siddiqui

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Outcomes of Triple-Negative Versus Non-Triple-Negative Breast Cancers Managed with Breast-Conserving Therapy

Bhatti

Khan

Siddiqui

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…49 Finally, in the report of Egawa et al 41 the median age of the patients was 10 years younger than ours, with predominance of pre-menopausic patients, with breast tumors that have different biologic characteristics from those developed in postmenopausal patients. 50 These facts make any comparison limited.…”

Section: Discussionmentioning

confidence: 99%

Tumoral expression of BRCA1, Estrogen receptor alpha and ID4 protein in patients with sporadic breast cancer

Roldán¹,

Delgado²,

Musé³

2006

Cancer Biology & Therapy

View full text Add to dashboard Cite

Introduction: BRCA1 expression is downregulated in a third of sporadic breast cancers (SBC). Most of the tumors in which BRCA1 function is diminished do not express estrogen receptor alpha (ER). Recent studies suggest that the inhibitor of DNA binding (ID)-4 could participate in the hormonal regulation of BRCA1 expression.Objective: To study the relationship between tumoral expression of BRCA1, ER and ID4 in SBCs.Patients and methods: Forty patients with pathologic confirmation of SBC were included in this study. The mRNA expression of BRCA1, ER and ID4, determined by reverse transcription and polymerase chain reaction (RT-PCR), was correlated with the expression of gliceraldehid-3-phosphate-dehydrogenase (GAPDH). The results were analyzed using two-sided nonparametric tests (Chi-square and Spearman's rank correlation test) with α < 0.05.Results: Most of the tumors that expressed BRCA1 mRNA were ER-positive (p < 0.0001). In addition, a positive correlation was observed between the level of expression of these mRNAs (rs = 0.75 95% CI = 0.57-0.86; p < 0.0001). An inverse association was observed between the mRNA expression of BRCA1 and ID4 (p = 0.024) and a negative correlation between their levels of expression (rs = -0.35 95% CI -0.59 a -0.04; p = 0.028). Moreover, a negative correlation was stated between the level mRNAs of ER and ID4 (rs = -0.45 95% CI -0.66 a -0.16; p = 0.0039).Discussion: In this study we demonstrate an association between the tumoral expression of BRCA1, ER and ID4 in patients with SBC. These results are in concordance with previous studies, however, to our knowledge, no other reports have described a relationship between the expression of ID4 and ER at the mRNA level in human breast cancers. These results suggest that ID4 participates in the molecular events that regulate BRCA1 and ER expression, suggesting its role as a tumor marker or potential therapeutic target.

show abstract

“…As early-onset breast cancer in itself is associated with a poorer prognosis (Sidoni et al, 2003), it may be advantageous to initiate breast cancer screening among multiparous women with the IGF1-19/-19 genotype at an earlier age. Alternative screening methods may be needed in this age group as mammography shows poor sensitivity in young women (Houssami et al, 2003).…”

Section: Igf1-19/-mentioning

confidence: 99%

“…The median age at breast cancer diagnosis in women in Sweden is 60 years; approximately 4% of women are 40 years or younger at diagnosis (data from the Swedish Cancer Registry). The prognosis is often poorer in younger than in older women (Sidoni et al, 2003) in terms of overall survival and relapse (Han et al, 2004), partly because young women do not benefit from breast cancer screening and early-onset breast cancers are usually detected clinically at a more advanced stage. In Lund, Sweden, mammography screening is initiated at age 45 years and is performed every 18 months until the age of 74 years.…”

mentioning

confidence: 99%

Absence of the common Insulin-like growth factor-1 19-repeat allele is associated with early age at breast cancer diagnosis in multiparous women

et al. 2007

View full text Add to dashboard Cite

Multiparity decreases the risk of breast cancer in white women, whereas it is a risk factor in black women o50 years. Early-onset breast cancer (o50 years) has been associated with high insulin-like growth factor-1 (IGF-1) levels. Absence of the common IGF1 19 cytosine-adenine (CA)-repeat allele (IGF1-19/-19) inverts the effect of several non-genetic factors on breast cancer risk but the interaction between IGF1-19/-19 and multiparity on breast cancer risk is unknown. As IGF1-19/-19, multiparity and early-onset breast cancer are more common in black than in white women, we aimed to study whether multiparity combined with IGF1-19/-19 increases the risk of early-onset breast cancer. Four hundred and three breast cancer patients diagnosed in Lund, Sweden, at age 25 -99 years were genotyped for the IGF1 CA-repeat length using fragment analysis. Overall, 12.9% carried the IGF1-19/-19 genotype. There was a highly significant interaction between multiparity and IGF1-19/-19 on age at breast cancer diagnosis (P ¼ 0.007). Among IGF1-19/-19 patients, multiparity was associated with a 9.2 year earlier age at diagnosis compared with uniparity or nulliparity (P ¼ 0. Breast cancer is the most common malignancy in women worldwide (Parkin et al, 2001(Parkin et al, , 2002. Approximately 10% of women living in Sweden will develop the disease during their lifetime. The median age at breast cancer diagnosis in women in Sweden is 60 years; approximately 4% of women are 40 years or younger at diagnosis (data from the Swedish Cancer Registry). The prognosis is often poorer in younger than in older women (Sidoni et al, 2003) in terms of overall survival and relapse (Han et al, 2004), partly because young women do not benefit from breast cancer screening and early-onset breast cancers are usually detected clinically at a more advanced stage. In Lund, Sweden, mammography screening is initiated at age 45 years and is performed every 18 months until the age of 74 years. As of today, no tests are routinely performed to identify the subgroup of women who do not belong to high-risk breast cancer families (eg BRCA1 families) but who would nevertheless benefit from breast cancer screening at an earlier age owing to an increased risk for early-onset breast cancer.Breast cancer risk is determined by genetic factors and nongenetic factors, for example, reproductive factors (Beral and Reeves, 1993;Kelsey et al, 1993). An increased age at first full-term pregnancy and low parity have been associated with an increased risk of developing breast cancer in the developed world (Kelsey et al, 1993). In the short term, a first full-term pregnancy increases the risk of breast cancer (Beral and Reeves, 1993). Each subsequent live-birth reportedly decreases the risk of breast cancer by 30% and after three full-term pregnancies, the short-term risk of developing breast cancer is similar to the risk of nulliparous women (McCredie et al, 1998). In the long-term, a full-term pregnancy confers a decreased risk of developing breast cancer (McCredie et al, 1998) and ...

show abstract

Breast cancer in young women: clinicopathological features and biological specificity

Cited by 116 publications

References 20 publications

Outcomes of Triple-Negative Versus Non-Triple-Negative Breast Cancers Managed with Breast-Conserving Therapy

Outcomes of Triple-Negative Versus Non-Triple-Negative Breast Cancers Managed with Breast-Conserving Therapy

Tumoral expression of BRCA1, Estrogen receptor alpha and ID4 protein in patients with sporadic breast cancer

Absence of the common Insulin-like growth factor-1 19-repeat allele is associated with early age at breast cancer diagnosis in multiparous women

Contact Info

Product

Resources

About