Breast cancer in young women: Imaging and clinical course

Langman, Eun L.; Kuzmiak, Cherie M.; Brader, Rachel; Thomas, Samantha M.; Alexander, Sophia L; Lee, Sheila S.; Jordan, Sheryl G.

doi:10.1111/tbj.14261

Cited by 6 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mammography could not detect any abnormalities, while US results were equivocal. This agrees with Langman et al 28 who stated that in patients considering breast conservation, MRI could detect disorders that could not be viewed on US or mammography and assist in clinical decisions.…”

Section: Discussionsupporting

confidence: 90%

Magnetic resonance imaging of the breast

Nagadi,

Elsayed

2024

SMJ

View full text Add to dashboard Cite

Objectives: To investigate whether magnetic resonance imaging (MRI) best detects early malignancy in high-risk women. Methods: A retrospective, cross-sectional study, carried out at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, included 419 female breast cancer patients aged 16-84 years (mean age of 49). Data were collected from the radiological department’s database to compare the MRI, ultrasound (US), and mammography results, with or without tissue biopsy. Results: In diagnosing benign versus malignant lesions, MRI showed significant agreement with tissue biopsy, with high sensitivity (70%) and specificity (87%); its positive predictive value (PPV) was 92% and negative predictive value (NPV) was 56%. While US has a PPV of 84% and NPV of 63%; with a sensitivity (79%) and specificity (71%). In patients without tissue biopsy, there was little difference between mammography and US compared with MRI results. Conclusion: Magnetic resonance imaging is more effective than US and mammography for early detection of BC. It showed high sensitivity in detecting breast lesions and high specificity in characterizing their nature when correlated with pathological results. Ultrasound screening followed by MRI is suggested for undetected or suspected lesions. This will increase the breast lesion detection rate, reduce unneeded tissue biopsies, and enhance the disease’s survival rate.

show abstract

Section: Discussionsupporting

confidence: 90%

Magnetic resonance imaging of the breast

Nagadi,

Elsayed

2024

SMJ

View full text Add to dashboard Cite

show abstract

“…In our study, the most common histological type of breast cancer was invasive ductal carcinoma, which is in line with prior studies (17,20,22,26) and may contribute to poor prognosis.…”

Section: Bse Breast Selfexaminationsupporting

confidence: 92%

The imaging findings and diagnostic value of radiology modalities to assess breast malignancy among women aged younger than 30 years

Moradpour,

Azizinik,

Zeidabadi

et al. 2023

Acta Radiol

View full text Add to dashboard Cite

Background Breast cancer mainly affects women aged >50 years; however, younger women may also have advanced breast cancer, so early detection is important. Purpose To collect and review the imaging findings of women aged <30 years with breast cancer to find better diagnostic approaches for the early diagnosis of breast cancer in young women. Material and Methods In this study, 45 patients aged <30 years with a diagnosis of breast cancer were evaluated. Imaging assessments were performed based on ultrasound, mammography, and magnetic resonance imaging (MRI) findings. Finally, the findings were compared with the pathological results. Results Predominant findings in ultrasound included irregular spiculated mass in 59.4%. In mammography, irregular high-density mass (46.5%) and suspicious micro calcification (42.8%) were the most common findings. In MRI, the predominant feature was a heterogeneous enhancing mass with an irregular shape and irregular margin (81%) with a 45% plateau and 36% washout kinetic pattern. In the pathology assessment, invasive ductal carcinoma was the most common finding (84.4%). All three modalities—MRI, ultrasonography, and mammography—are valuable, with sensitivities of 100%, 93.3%, and 90%, respectively. Conclusion Ultrasound, mammography, and MRI are highly sensitive and accurate tools for detecting breast cancer lesions in young women. Regular clinical breast examination with breast self-examination, and in suspected cases, ultrasound as the first imaging modality followed by mammography and/or MRI are the preferred diagnostic approach.

show abstract

“…In most studies, age is known as a prognostic factor. Young women tend to have higher rate of local recurrence and lower survival rate than older women (Bollet et al, 2007;He et al, 2017;Langman et al, 2021). In the present study, patients less than 40 years old had lower survival rates.…”

Section: Discussionsupporting

confidence: 42%