Breast cancer: Interaction between oxidant-antioxidant dynamics and inflammation in Indian females

Goswami, Binita; Rajappa, Medha; Gupta, Nikhil; Mahto, Mala; Hadke, Niladhar S.; Mishra, Tarun

doi:10.3233/cbm-2009-0122

Cited by 8 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cells that incur genetic damage (initiated cells) proliferate in an inflammatory micro environment due to the growth factors and cytokines released by the inflammatory cells. The molecular interplay between inflammatory cytokines with the other neoplastic processes through the NF-kB pathway also adds to the problem [6].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Oxidative Stress and Inflammatory Process in Patients of Multiple Myeloma

et al. 2012

Self Cite

View full text Add to dashboard Cite

Multiple myeloma is a disseminated malignancy of monoclonal plasma cells that accounts for 15 % of all hematological cancers. The present study was conducted to evaluate the role of inflammation and oxidant-antioxidant dynamics in the etiology of this disease. The study population comprised of 20 cases of multiple myeloma and 20 healthy controls. The parameters evaluated were serum malondialdehyde (MDA), superoxide dismutase (SOD) and ferritin levels. The serum MDA levels were 1.9 ± 0.96 nmol/ml in cases as compared to 0.98 ± 0.55 nmol/ml in the controls. Similarly, a statistically significant difference was noted in the SOD and ferritin levels between the cases and controls (93.2 ± 23.8 vs. 210.1 ± 190.5 U/ml and 285.8 ± 216.4 vs. 131.8 ± 30.1 ng/ml respectively). Our study highlights the imbalance in the oxidant-anti oxidant mechanism and the role of smoldering inflammation in the etiology of multiple myeloma.

show abstract

Section: Introductionmentioning

confidence: 99%

Assessment of Oxidative Stress and Inflammatory Process in Patients of Multiple Myeloma

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…Apart from interacting with the host human system, tumor cells also interact with other host physiological pathways such as the platelet and coagulation pathways [13,14]. Tumor growth and hypoxia induce release of tissue factor [15].…”

Section: Resultsmentioning

confidence: 99%

Association of Serum Fibrinogen and Plasma VEGF Levels with Tumor Characteristics and Treatment Response in Operable Breast Carcinoma

Khowal

Yelamanchi²,

Gupta³

et al. 2022

SN Compr. Clin. Med.

Self Cite

View full text Add to dashboard Cite

Background and Aims:A search for factors predicting the behavior of the tumor, its invasiveness, metastasis, response to treatment and prognosis is the primary focus of breast cancer research. The objective of the present study was to study the association of brinogen and vascular endothelial growth factor (VEGF) with various parameters of breast carcinoma. Materials and methodsA case control was conducted in which brinogen and VEGF levels were compared between cases and controls and also with various characteristics of breast carcinoma such as T stage, lymph node positivity, grade, lymphovascular invasion and receptor status. The effect of surgery of breast cancer on brinogen and VEGF levels was also studied. ResultsThe levels of brinogen and VEGF were signi cantly higher in cases when compared to controls (p < 0.001). Increased brinogen level was signi cantly associated with higher grade of the tumor, lymph node metastasis and lymphovascular invasion. Increased VEGF level was signi cantly associated with higher grade and lymphovascular invasion of the tumor. After treatment there was a statistically signi cant fall in the levels of the above mediators (p < 0.001). ConclusionsSerum brinogen and plasma VEGF levels were signi cantly higher in patients of breast carcinoma and had signi cant association with invasiveness of the tumor. DeclarationsContributions: HKK conceptualized the study and conducted it. RY designed the methodology and wrote the manuscript. NG helped in data acquisition and reviewed the manuscript. BG conducted the study and was in charge of the biochemical tests conducted. AJ conducted the study and helped in data acquisition. MPA conducted the study and supervised it.

show abstract

“…It was reported that the state of angiogenesis, inflammation, and oxidative stress in patient suffered from breast cancer would pay important roles on the tumor progress and metastasis [47] and also it was found that there were the interplay between inflammatory pathways and oxidative stress in the pathogenesis of breast cancer [48]. While the patients of breast cancer were waiting for surgery treatment, the states of circadian disruption [49], improved serum levels of oxidative damage [50], inflammatory biomarkers and angiogenic factors [51] would make the tumor progress.…”

Section: Discussionmentioning

confidence: 99%

Reduction of Inflammatory Response by Way of Oxidative Stress with San Huang Decoction (SHD) In Perioperative Care: A Randomized Clinical Trial

Yu¹,

Weihe²,

Xu³

et al. 2017

IJCAM

View full text Add to dashboard Cite

Breast cancer: Interaction between oxidant-antioxidant dynamics and inflammation in Indian females

Cited by 8 publications

References 50 publications

Assessment of Oxidative Stress and Inflammatory Process in Patients of Multiple Myeloma

Assessment of Oxidative Stress and Inflammatory Process in Patients of Multiple Myeloma

Association of Serum Fibrinogen and Plasma VEGF Levels with Tumor Characteristics and Treatment Response in Operable Breast Carcinoma

Reduction of Inflammatory Response by Way of Oxidative Stress with San Huang Decoction (SHD) In Perioperative Care: A Randomized Clinical Trial

Contact Info

Product

Resources

About