Breast Cancer Metastasis to Nasal Septum

Abstract

The most common malignancy and leading cause of cancer-related deaths in women is breast cancer (BC). Despite significant progress in the management of BC, advanced disease remains an important cause of mortality. 1 Distant metastases are present in 4% of the patients at the time of presentation, with many more subsequently developing distant disease. 2 The most common metastatic sites in advanced BC are bone, lungs, pleura, liver, and brain. Head and neck (H&N) is a rare site for metastases. In most cases, bony involvement of jaws and supraclavicular lymphadenopathy is observed. 3 The metastatic spread to the nasal cavity has been rarely reported, with most cases of renal cell carcinoma. 4-6 BC metastases to the nasal cavity are extremely rare. [7][8][9] Herein, we present a case of nasal septum metastasis from BC. CASE REPORTA 54-year-old female patient presented with a lump in the right breast. She was diagnosed with BC, and a right radical mastectomy and axillary lymph node dissection was performed. The pathology revealed a triple negative invasive ductal carcinoma, T3N0M0. She subsequently received four cycles of adjuvant doxorubicin-cyclophosphamide and 12 cycles of weekly paclitaxel. However, she presented with bilateral pulmonary and bony lesions after 2 years of follow-up. Additionally, she had locoregional recurrence with an ulcerated mass on the surgical site. She had palliative 66 Gy radiotherapy to the anterior wall of the right thorax. She was further treated with palliative 6 cycles of docetaxel, 9 cycles of docetaxel-181 181 181