Breast Cancer Metastatic to the Uterine Cervix: Analysis of a Rare Event

Hepp, H; Hoos, Axel; Leppien, G.; Wallwiener, D.

doi:10.3109/07357909909032855

Cited by 13 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In most cases cervical metastasis of breast cancer is a manifestation of widespread disease. In 67-89% of the reported cases distant metastases of other sites were present at diagnosis of cervical metastasis [4,5]. In contrast to former reports, in which a preference of lobular breast cancers metastatic to the cervix was stated, more recent findings showed no preference of the histological type [5,[7][8][9].…”

Section: A B C Dcontrasting

confidence: 47%

“…The frequency of cervical metastases of breast cancer is estimated to lie in a range of 0.8-1.7% [3,6]. This low incidence may be explained by the lack of routine autopsy: Hepp et al [5] reviewed reported cases of breast cancer metastatic to the uter- …”

Section: Discussionmentioning

confidence: 99%

“…This circumstance causes diagnostic problems in the absence of clinical symptoms. The vast majority of cases with cervical spreads are in an advanced stage of the disease at the time of diagnosis [4,5]. Here, we present a case where 2.5 years after initial diagnosis of breast cancer metastatic lesions of the cervix were discovered by routine pelvic ultrasound examination.…”

Section: Introductionmentioning

confidence: 97%

“…In the absence of clinical symptoms and with a macroscopically normal cervix, serial Pap smears could give an early indication of abnormal cells. However, in case of clinical signs indicating cervical abnormality Hepp et al [5] suggested that in these patients a cervical biopsy should be performed because of the low negative predictive value of Pap smears.…”

Section: A B C Dmentioning

confidence: 99%

See 3 more Smart Citations

Uterine Cervical Metastasis of Breast Cancer: A Rare Complication that May be Overlooked

Pauer¹,

Viereck²,

Burfeind

et al. 2003

Oncol Res Treat

View full text Add to dashboard Cite

Background: Metastasis of distant malignancies to the cervix uteri is a rare occurrence and the frequency is approximately 4% for all tumours. However, the frequency of cervical metastasis of breast cancer is much lower and is estimated to range between 0.8 and 1.7%. With the exception of ovarian metastases, secondary tumours of the female genital tract are rather uncommon. Therefore, these conditions pose diagnostic problems for the clinician. Patient: A 40-year-old woman with the diagnosis of invasive ductal cell carcinoma of the right breast underwent mastectomy with dissection of axillary lymph nodes in 1998. Subsequently, the patient received 6 cycles of chemotherapy with cyclophosphamide, methotrexate and fluorouracil. The initial tumour stage was pT2, pN0 (0/13), M0, G2. The oestrogen and progesterone receptors were positive and expression of the C-erb-B2 coding oncogene was negative. Gynaecological and ultrasonographic examination revealed a normal cervix without evident lesions. Exfoliative cytology was negative. 14 months after treatment the patient presented with an axillary relapse and surgery, second-line chemotherapy with doxorubicine and radiation therapy of the chest wall and the axilla were performed. The patient developed liver metastases 14 months later and at this time ultrasonographic pelvic examination revealed a 2.2 cm tumour of the cervix with good vascularisation. The patient had no clinical symptoms, i.e. no vaginal bleeding or discharge. Sonomorphologically this tumour appeared as a leiomyoma of the cervix. Cervical biopsies and curettage, however, revealed metastatic carcinoma expressing oestrogen and progesterone receptors consistent with the primary breast cancer. Under palliative chemotherapy with docetaxel progression of liver metastases and cervical metastasis occurred and the patient died 9 months later. Conclusion: Metastatic involvement of the cervix should be considered in women with a history of breast cancer who present with vaginal bleeding or suspicious changes of the cervix on transvaginal ultrasound. Therefore, gynaecological and ultrasonographic examination of the pelvis represent an important part of the follow- up investigations in women with primary breast cancer.

show abstract

Section: A B C Dcontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: A B C Dmentioning

confidence: 99%

See 2 more Smart Citations

Uterine Cervical Metastasis of Breast Cancer: A Rare Complication that May be Overlooked

Pauer¹,

Viereck²,

Burfeind

et al. 2003

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

“…Initial presentation of breast cancer as clinically palpable axillary adenopathy with negative breast imaging (generally referred to as “occult breast cancer”) is a rare occurrence (0.3–0.8%) 3,5. Other unusual presenting symptoms of breast cancer include acute venous thrombosis,6 Mondor’s disease,7 pituitary insufficiency,8 vaginal bleeding secondary to metastasis to uterine cervix,9 and paraneoplastic syndrome 10…”

Section: Discussionmentioning

confidence: 99%