Breast cancer mortality in a resource-poor country: A 10-year experience in a tertiary institution

Amin, Said; Ewunonu, H A S; Oguntebi, Emmanuel; Liman, Idris

doi:10.4103/smj.smj_64_15

Cited by 18 publications

(18 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study found that about a half (49%) of the patients were premenopausal in their third and fourth decades of life, a finding consistent with reports from previous studies 1112. This category of patients were observed to have tumors that ran aggressive course probably because of hormonal influence.…”

Section: Discussionsupporting

confidence: 92%

Epidemiology and challenges of managing breast cancer in Keffi, North-Central Nigeria: A preliminary report

et al. 2019

View full text Add to dashboard Cite

Background:Breast cancer is now the commonest female malignancy worldwide. The prognosis of such depends on the histopathological type, biological behavior, stage at presentation, availability of adequate oncological services.Aims and Objectives:The aim of this this study is to evaluate the statistics and challenges of breast cancer management in the study centre and compare with other centres.Materials and Methods:This is a prospective, descriptive study that spanned over a period of 4 years (January 2015-December 2018). The study was carried out in the General surgery division of the Surgery Department of the Federal Medical Centre, Keffi.Results:A total of 199 patients were recruited into this study out of which 196 (98.25%) were females and 3 (1.5%) were males. Their age ranged between 20-60 years. The commonest histopathological variant diagnosed is invasive ductal carcinoma (NOS). Early presentation was seen in 54 (<30%) while 145 (>70%) patients had late clinical presentation.Conclusion:Diagnosing and managing breast cancers successfully are mitigated my myriads of factors. Public awareness and provision of adequate care facilities will improve overall survival.

show abstract

Section: Discussionsupporting

confidence: 92%

Epidemiology and challenges of managing breast cancer in Keffi, North-Central Nigeria: A preliminary report

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Late stage at presentation has been associated with increased risk of mortality, especially in Low- and middle-income countries where social factors play a pivotal role in timing of presentation as well as acceptance of orthodox treatment, including breast-conserving surgery and mastectomy [ 6 – 8 ]. While surgical extirpation continues to be the mainstay of loco-regional disease control by achieving negative margins and lymph node clearance, it is well documented that the nodal status at diagnosis significantly affects overall survival, with axillary lymph nodal metastasis being a critical index of prognostication [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of axillary node-positivity and surgical resection margins on survival of women treated for breast cancer in Ibadan, Nigeria

Ayandipo¹,

Ogun²,

Adepoju³

et al. 2020

ecancer

View full text Add to dashboard Cite

Introduction: Oncologic surgical extirpation, the mainstay of loco-regional disease control in breast cancer, is aimed at achieving negative margins and lymph node clearance. Even though axillary lymph nodal metastasis is a critical index of prognostication, establishing the impact of lymph node ratio (LNR) and adequate surgical margins on diseasespecific survivorship would be key to achieving longer survival. This study examines the prognostic role of pN (lymph nodes positive for malignancy), LNR and resection margin on breast cancer survival in a tertiary hospital in Ibadan, Nigeria. Methods: We conducted a longitudinal cohort study of 225 patients with breast carcinoma, documented clinico-pathologic parameters and 5-year follow up outcomes-distant metastasis and survival. Chi-square test and logistic regression analysis were used to evaluate the interaction of resection margin and proportion of metastatic lymph nodes with patients' survival. The receiver operating characteristic curve was plotted to determine the proportion of metastatic lymph nodes which predicted survival. The survival analysis was done using Kaplan-Meier method. Results: Sixty (26.7%) patients of the patients had positive resection margins, with the most common immuno-histochemical type being Lumina A. 110 (49%) patients had more than 10 axillary lymph nodes harvested. The mean age was 48.6 + 11.8 years. Tumour size (p = 0.018), histological type (p = 0.015), grade (p = 0.006), resection margin (p = 0.023), number of harvested nodes (p < 0.01), number of metastatic nodes (p < 0.001) and loco-regional recurrence (p < 0.01) are associated with survival. The overall 5-year survival was 65.3%. Conclusion: Unfavourable survival outcomes following breast cancer treatment is multifactorial, including the challenges faced in the multimodal treatment protocol received by our patients.

show abstract

“…8 This indicates that less than 50% of Nigerian patients with BC survive for 5 years or longer after diagnosis. However, because figures for BC mortality are scarce, 9 the true proportion of deaths could be significantly higher. The shocking increase seen in the 2016 cancer incidence data in Nigeria makes conducting studies regarding early diagnosis of BC in Nigeria crucial.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sociodemographic Variables on Patient and Diagnostic Delay of Breast Cancer at the Foremost Health Care Institution in Nigeria

Olarewaju

Oyekunle

Bamiro

2019

JGO

View full text Add to dashboard Cite

PURPOSE Breast cancer (BC) has the highest mortality rate among women with any form of cancer in developing countries. Unfortunately, patients with BC in Nigeria commonly present with late-stage disease. The current study examined the types and magnitude of delay in BC diagnosis at the foremost hospital in Nigeria and also identified the influencing factors. MATERIALS AND METHODS This cross-sectional study involved questionnaires given to 275 patients with BC at University College Hospital, Ibadan, Nigeria, from August to October 2018. Sociodemographic characteristics and information relevant to management of their health problem were obtained after ethical committee approval. Data collected were analyzed by SPSS (version 23; SPSS, Chicago, IL) to assess the types and magnitude of delay experienced by patients, as well as identify related determinants using the appropriate statistical test with P = .05. RESULTS The mean age of respondents was 49 (± 11.9) years with the majority being Yoruba (n = 154; 56%), Christians (n = 211; 76.7%), married (n = 193; 70.2%), employed (n = 151; 54.9%), having tertiary education (n = 142; 51.6%) and an average income of more than 18,000 naira (n = 176; 64%). Patient delay and diagnostic delay were observed among 97 respondents (35.3%) and 84 respondents (30.5%), respectively. Although patient delay was significantly associated with age, ethnicity, and marital status, the only variable significantly associated with diagnostic delay was marital status ( P < .05). Level of income, education, employment status, and religion did not significantly ( P > .05) contribute to either of these delays. CONCLUSION BC management at the pioneer Nigerian teaching hospital is challenged by both delays in patient presentation at clinics and delays in the process of being diagnosed. Such delays need to be addressed to achieve favorable outcome of patients with BC in Nigeria.

show abstract

Breast cancer mortality in a resource-poor country: A 10-year experience in a tertiary institution

Cited by 18 publications

References 1 publication

Epidemiology and challenges of managing breast cancer in Keffi, North-Central Nigeria: A preliminary report

Epidemiology and challenges of managing breast cancer in Keffi, North-Central Nigeria: A preliminary report

Impact of axillary node-positivity and surgical resection margins on survival of women treated for breast cancer in Ibadan, Nigeria

Effect of Sociodemographic Variables on Patient and Diagnostic Delay of Breast Cancer at the Foremost Health Care Institution in Nigeria

Contact Info

Product

Resources

About