Breast Cancer Prevention

Reeder, Jennifer G.; Vogel, Victor G.

doi:10.1007/978-0-387-73161-2_10

Cited by 31 publications

(22 citation statements)

References 48 publications

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“…Female sex and older age are the primary risk factors for breast cancer (Reeder et al, 2008). Other possible risk factors for breast cancer may be genetics, lack of childbearing or lack of breast feeding, increase level of some hormones (Yager et al, 2006) change in dietary patterns, obesity, exposure to light pollution, tobacco, intake of high fat diet, alcohol intake (Boffetta et al, 2006) related to higher cholesterol levels (Kaiser et al, 2013).…”

mentioning

confidence: 99%

Prevalence, Risk Factors and Disease Knowledge of Breast Cancer in Pakistan

Asif¹,

Sultana²,

Akhtar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

101

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mentioning

confidence: 99%

Prevalence, Risk Factors and Disease Knowledge of Breast Cancer in Pakistan

Asif¹,

Sultana²,

Akhtar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

101

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“…The rate of progression of BC depends on various factors, such as the histological type of the tumor, the woman's age, the hormonal conditions, the tumor microenvironment, the status of the receptors, and the genetic material (Reeder and Vogel, 2008). Despite the efficacy of many anti-cancer agents and the improved disease-free survival and overall survival of breast cancer patients, some patients still succumb to this disease (Jemal et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Molecular-level effects of eribulin and paclitaxel on breast cancer based on differential co-expression network analysis

Qin

Chen

2016

Genet. Mol. Res.

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ABSTRACT. We investigated the effects of eribulin and paclitaxel on breast cancer (BC) by exploring molecular biomarkers and pathways. Co-expression networks were constructed by differentially coexpressed genes and links, and centralities were analyzed to explore the hub genes. Pathway-enrichment analysis was performed. The hub genes were validated using the polymerase chain reaction and western blotting. A total of 132 and 153 differentially expressed genes were identified in BC cell lines treated with eribulin and paclitaxel, respectively. Six hub genes were identified in two co-expression networks. The spliceosome pathway was the mutually significant pathway. The validation analysis was basically consistent with the bioinformatics. We successfully identified several hub genes and pathways relevant to the effects of eribulin and paclitaxel on BC based on the network analysis.

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“…Breast cancer is a type of cancer originating from breast tissue such as the inner lining of milk ducts or the lobules that supply the ducts with milk (2)(3)(4). Breast cancer is 100 times more common in women than in men and accounts for 22.9% of all cancer types in women (5,6). Therefore, the primary risk factors for breast cancer are female gender and older age (7,8).…”

Section: Introductionmentioning

confidence: 99%

miRNA profiling reveals a potential role of milk stasis in breast carcinogenesis

Gong

et al. 2014

International Journal of Molecular Medicine

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The tumor microenvironment plays an important role in breast carcinogenesis. Milk acts as an important microenvironment of breast cancer, but its role in breast carcinogenesis is largely unknown. Milk stasis may exist in the breast for a number of years after breastfeeding. In the present study, we reported the first microRNA (miRNA) profiling of milk from patients with milk stasis. We identified 266 known miRNAs and 271 novel miRNAs in 10 milk stasis only samples, 271 known miRNAs and 140 novel miRNAs in 10 milk stasis plus breast neoplasm samples by deep sequencing. miRNA profiles were different between the two groups. Furthermore, nine tumor suppressor miRNAs such as miR-29a, miR-146 and miR-223 were significantly downregulated, while seven oncogenic miRNAs such as miR-451, miR-486, miR-107, miR-92 and miR-10 were significantly upregulated in the milk of milk stasis plus neoplasm patients. Three of the identified miRNAs (miR-140, miR-21 and let-7a) were selected using real-time PCR, confirming that these miRNAs were highly expressed. The results also showed that the three miRNAs detected were more abundant in the milk than in the blood. In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood.

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Breast Cancer Prevention

Cited by 31 publications

References 48 publications

Prevalence, Risk Factors and Disease Knowledge of Breast Cancer in Pakistan

Prevalence, Risk Factors and Disease Knowledge of Breast Cancer in Pakistan

Molecular-level effects of eribulin and paclitaxel on breast cancer based on differential co-expression network analysis

miRNA profiling reveals a potential role of milk stasis in breast carcinogenesis

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