Breast cancer recurrence after reconstruction: know thine enemy

Brett, Elizabeth A.; Aitzetmüller, Matthias M.; Sauter, Matthias A.; Huemer, Georg M.; Machens, Hans‐Günther; Duscher, Dominik

doi:10.18632/oncotarget.25602

Cited by 23 publications

(14 citation statements)

References 119 publications

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“…In vivo experiment further verified that SNHG20 promoted tumor growth in glioblastoma. Accumulating evidences indicate that the existence of cancer stem cells is correlated with cell proliferation, migration and self-renewal [28][29][30]. Thus, we further investigated the potential of SNHG20 to regulate stemness in glioblastoma.…”

Section: Discussionmentioning

confidence: 98%

LncRNA SNHG20 promotes tumorigenesis and cancer stemness in glioblastoma via activating PI3K/Akt/mTOR signaling pathway

Gao¹,

He²,

Zhu³

et al. 2019

neo

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Long noncoding RNAs (lncRNAs) play crucial roles in the development of human cancers. LncRNA small nucleolar RNA host gene 20 (SNHG20) has been reported to be an oncogene in several cancers, whereas the specific role of SNHG20 in glioblastoma is unclear. In this study, we found that SNHG20 was significantly upregulated in glioblastoma tissues and cell lines. Survival analysis suggested that high expression of SNHG20 indicated the low overall survival rate of glioblastoma patients. Subsequently, gain or loss-of-function assays were carried out to examine the effect of SNHG20 on glioblastoma cell proliferation and apoptosis. We found that SNHG20 knockdown obviously suppressed cell proliferation, increased cell apoptosis and impaired stem properties, while SNHG20 overexpression led to the opposite results. In vivo experiment demonstrated that knockdown of SNHG20 efficiently suppressed cell growth in vivo. Furthermore, western blotting demonstrated that the PI3K/Akt/mTOR signaling pathway was activated by SNHG20 in glioblastoma cells. At last, rescue assays validated that PI3K/Akt/mTOR signaling pathway was involved in the glioblastoma progression mediated by SNHG20. Taken together, this study revealed that SNHG20 regulated PI3K/Akt/mTOR signaling pathway to promote tumorigenesis and stemness of glioblastoma.

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Section: Discussionmentioning

confidence: 98%

LncRNA SNHG20 promotes tumorigenesis and cancer stemness in glioblastoma via activating PI3K/Akt/mTOR signaling pathway

Gao¹,

He²,

Zhu³

et al. 2019

neo

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“…Data mining methods may help reduce the number of false positives and false-negative results in physicians' decision-making [ 12 , 32 ]. Accordingly, new approaches, such as knowledge discovery in databases (KDD), including data mining algorithms, have become increasingly popular and a desirable research tool for medical science researchers.…”

Section: Introductionmentioning

confidence: 99%

“…Cancer is a multifactorial disease and beside genetic factors, personal lifestyle, smoking, and diet play impressive effects in the etiology of cancer. There is always a balance among the amount of proliferation, the cell senescence, and the differentiation in a healthy organism, this balance is lost during cancer formation [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Modeling and comparing data mining algorithms for prediction of recurrence of breast cancer

et al. 2020

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Breast cancer is the most common invasive cancer and the second leading cause of cancer death in women. and regrettably, this rate is increasing every year. One of the aspects of all cancers, including breast cancer, is the recurrence of the disease, which causes painful consequences to the patients. Moreover, the practical application of data mining in the field of breast cancer can help to provide some necessary information and knowledge required by physicians for accurate prediction of breast cancer recurrence and better decision-making. The main objective of this study is to compare different data mining algorithms to select the most accurate model for predicting breast cancer recurrence. This study is cross-sectional and data gathering of this research performed from June 2018 to June 2019 from the official statistics of Ministry of Health and Medical Education and the Iran Cancer Research Center for patients with breast cancer who had been followed for a minimum of 5 years from February 2014 to April 2019, including 5471 independent records. After initial pre-processing in dataset and variables, seven new and conventional data mining algorithms have been applied that each one represents one kind of data mining approach. Results show that the C5.0 algorithm possibly could be a helpful tool for the prediction of breast cancer recurrence at the stage of distant recurrence and nonrecurrence, especially in the first to third years. also, LN involvement rate, Her2 value, Tumor size, free or closed tumor margin were found to be the most important features in our dataset to predict breast cancer recurrence.

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“…Aufgrund der regenerativen Mechanismen liegt es nahe, dass MSCs potentiell auch zum Wiederauftreten von Brustkrebs führen könnten [91,92] [102].…”

Section: Karzinogenes Potentialunclassified

Stammzellen in der Regenerativen Medizin – Translationale Hürden und Möglichkeiten zur Überwindung

Klietz

Kückelhaus

Kaiser³

et al. 2020

Handchir Mikrochir Plast Chir

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ZusammenfassungDer Einsatz von mesenchymalen Stammzellen in der regenerativen Medizin wird immer populärer. Nichtsdestotrotz ist ihre Anwendung im klinischen Alltag noch immer limitiert. Zahlreiche ethische, rechtliche und translationale Probleme sowie Ungewissheit bzgl. der Sicherheit hemmen noch immer die Entstehung von entsprechenden Therapien aus vielversprechenden wissenschaftlichen Ansätzen.Diese Arbeit soll die Hauptprobleme bei der Translation von stammzellbasierten Therapien aus der Grundlagenforschung und Präklinik in den klinischen Alltag darstellen, sowie Ansätze aufzeigen, diese zu überwinden.

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Breast cancer recurrence after reconstruction: know thine enemy

Cited by 23 publications

References 119 publications

LncRNA SNHG20 promotes tumorigenesis and cancer stemness in glioblastoma via activating PI3K/Akt/mTOR signaling pathway

LncRNA SNHG20 promotes tumorigenesis and cancer stemness in glioblastoma via activating PI3K/Akt/mTOR signaling pathway

Modeling and comparing data mining algorithms for prediction of recurrence of breast cancer

Stammzellen in der Regenerativen Medizin – Translationale Hürden und Möglichkeiten zur Überwindung

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