Breast cancer research in Iran: a scientometric analysis of publications output from 1991 to 2015 in Scopus

Zarei, Mohammadreza; Bagheri-Saweh, Mohammad Iraj; Rasolabadi, Masoud; Vakili, Ronak; Seidi, Jamal; Kalhor, Marya Maryam; Etaee, Farshid; Gharib, Alireza

doi:10.19082/3816

Cited by 14 publications

(29 citation statements)

References 18 publications

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“…Breast cancer is known to be the most common type of cancer in women worldwide (Asif, Sultana, Ahmed, Akhtar, & Tariq, ; Zarei et al, ). Previous evidences reveal that many natural compounds induce cell death in breast cancer cells without not hurting normal cells, which is very attractive to cancer research (Millimouno, Dong, Yang, Li, & Li, ; H. Wang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA‐MB231 breast cancer cells

Lee

Sim

Jung

et al. 2018

Phytotherapy Research

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Though lambertianic acid (LA) was known to exert antitumor effect in liver and prostate cancers, its underlying anticancer mechanism is never reported in breast cancers so far. Thus, in this study, apoptotic mechanism of LA was elucidated in MDA-MB-231 breast cancer cells. Here, LA increased cytotoxicity in MCF-7 and MDA-MB-231 cells; enhanced sub-G1 population, G2/M arrest, and cleaved poly(ADP-ribose) polymerase; activated phosphorylation of AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase pathway; and also suppressed phosphorylation of AKT and the expression of forkhead box M1 (FOXM1), X-linked inhibitor of apoptosis protein, B-cell lymphoma 2, and CyclinB1 in MDA-MB-231 cells. Furthermore, AMPK inhibitor compound C reversed the effect of LA on FOXM1, Cyclin B1, and cleaved poly(ADP-ribose) polymerase in MDA-MB-231 cells. Notably, immunoprecipitation revealed that LA disturbed the direct binding of AKT and FOXM1 in MDA-MB-231 cells. Overall, these findings suggest that LA-induced apoptosis is mediated via activation of AMPK and inhibition of AKT/FOXM1 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA‐MB231 breast cancer cells

Lee

Sim

Jung

et al. 2018

Phytotherapy Research

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show abstract

“…2) Although breast cancer incidence and prevalence are increasing, breast cancer mortality in high-income countries is decreasing because of early detection through mammogram screening and therapeutic advances at the community level. 3) Because the stage of cancer is considered to be the most important factor for the prognosis of most types of cancers and breast cancer is the leading reason for reduction of cancer-related mortality, early detection greatly contributes to decreasing the burden of cancer. 4) Women's awareness plays an important role in the effective diagnosis of breast cancer at an early stage.…”

Section: Introductionmentioning

confidence: 99%

“…14) Thus, further efforts should be made to motivate women to undergo screening and diagnostic mammogram procedures. 3) Given these data, effective factors on early detection of breast cancer should be explored; therefore, this study aimed to explore culture-specific barriers to mammography among Iranian women.…”

Section: Introductionmentioning

confidence: 99%

Perceived Barriers to Mammography Adoption among Women in Iran: A Qualitative Study

et al. 2020

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Background: Breast cancer is the most commonly diagnosed tumorous cancer and the second leading cause of cancer-related deaths among women worldwide. This study aimed to qualitatively explore the barriers to mammography adoption among Iranian women. Methods: This study is a qualitative component of a large research project on exploratory sequential mixed method design, utilizing conventional content analysis. In total, 24 participants were selected from among women who had participated in the first phase of the study. Data were collected through in-depth, semi-structured interviews. Results: Five main themes were extracted, consisting of unawareness of mammography, fear control, priority of mammography needs, inadequate competency of mammography centers, and a sense of losing family support. Conclusion: Different perceived barriers within various levels (individual, intrapersonal, health systems, and community) play influential roles in women's decisions to participate in breast cancer screening program, which indicates the cultural aspect of perceived barriers in different communities and countries. The study provides the basis for intervention planning in this regard.

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“…Breast cancer is one of the causes of common tumor deaths in women worldwide [ 1 , 2 ]. Recently, target therapies have been conducted in breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Wnt3a/FOXM1/β-Catenin Axis and Activation of GSK3β and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers

Hwang

Lee

Jung

et al. 2018

IJMS

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Although Moracin D derived from Morus alba was known to have anti-inflammatory and antioxidant activities, the underlying antitumor mechanism of Moracin D has not been unveiled thus far. Thus, in the recent study, the apoptotic mechanism of Moracin D was elucidated in breast cancer cells. Herein, Moracin D exerted significant cytotoxicity in MDA-MB-231 and MCF-7 cells. Furthermore, Moracin D increased sub G1 population; cleaved poly (Adenosine diphosphate (ADP-ribose)) polymerase (PARP); activated cysteine aspartyl-specific protease 3 (caspase 3); and attenuated the expression of c-Myc, cyclin D1, B-cell lymphoma 2 (Bcl-2), and X-linked inhibitor of apoptosis protein (XIAP) in MDA-MB231 cells. Of note, Moracin D reduced expression of Forkhead box M1 (FOXM1), β-catenin, Wnt3a, and upregulated glycogen synthase kinase 3 beta (GSK3β) on Tyr216 along with disturbed binding of FOXM1 with β-catenin in MDA-MB-231 cells. Conversely, GSK3β inhibitor SB216763 reversed the apoptotic ability of Moracin D to reduce expression of FOXM1, β-catenin, pro-caspase3, and pro-PARP in MDA-MB-231 cells. Overall, these findings provide novel insight that Moracin D inhibits proliferation and induces apoptosis via suppression of Wnt3a/FOXM1/β-catenin signaling and activation of caspases and GSK3β.

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Breast cancer research in Iran: a scientometric analysis of publications output from 1991 to 2015 in Scopus

Cited by 14 publications

References 18 publications

Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA‐MB231 breast cancer cells

Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA‐MB231 breast cancer cells

Perceived Barriers to Mammography Adoption among Women in Iran: A Qualitative Study

Inhibition of Wnt3a/FOXM1/β-Catenin Axis and Activation of GSK3β and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers

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