Breast Cancer Stem Cells-derived Extracellular Vesicles Affect PPARG Expression by Delivering MicroRNA-197 in Breast Cancer Cells

Li, Lin; Xiong, Youyi; Wang, Nan; Zhu, Mingzhi; Gu, Yuanting

doi:10.1016/j.clbc.2022.02.006

Cited by 11 publications

(8 citation statements)

References 32 publications

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“…As previously demonstrated, ARRDC1-AS1 activated by STAT1 exerts oncogenic effects by sponging miR-432-5p and elevating PRMT5 expression in glioma [10] . Another important finding in our study was that ARRDC1-AS1 could act a sponge of miR-4731-5p and subsequently upregulated AKT1 expression.…”

Section: Discussionmentioning

confidence: 54%

“…BCSCs have the characteristics of chemotherapy resistance, radiotherapy resistance, hypoxia resistance, high tumorigenicity, high invasion, and metastasis [ [10] , [33] ]. These cells play an important role in the tumorigenesis, development, recurrence and metastasis of BC mainly through regulation of the tumor microenvironment (TME) [34] .…”

Section: Resultsmentioning

confidence: 99%

“…Recently, tumor cell-derived extracellular vesicles (EVs) can transfer molecules to neighboring cells to exert oncogenic properties, representing druggable targets [9] . For example, BCSCs-derived EVs (BCSCs-EVs) contribute to promotion of the metastatic potential of BC cells via delivery of miR-197 [10] . In this context, it is of significance to seek EVs-based therapy to treat BC in regulation of malignant phenotypes.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Breast cancer stem cell-derived extracellular vesicles transfer ARRDC1-AS1 to promote breast carcinogenesis via a miR-4731-5p/AKT1 axis-dependent mechanism

Lin

Cai

2023

Translational Oncology

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Section: Discussionmentioning

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Breast cancer stem cell-derived extracellular vesicles transfer ARRDC1-AS1 to promote breast carcinogenesis via a miR-4731-5p/AKT1 axis-dependent mechanism

Lin

Cai

2023

Translational Oncology

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“…HSP90AA1 is a target associated with colorectal cancer, non-small-cell, lung cancer, gastric cancer, breast cancer, and hepatocellular carcinoma [31][32][33][34][35][36]. It not only affects the survival of tumor 11 BioMed Research International cells but also acts on the invasion and migration of cancer cells and is closely related to the poor prognosis of tumors [37]. PPARG is a target associated with breast cancer, lung cancer, hypopharyngeal squamous cell carcinoma, esophageal carcinoma, and lung squamous cell carcinoma [38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology-Integrated Molecular Docking Reveals the Expected Anticancer Mechanism of Picrorhizae Rhizoma Extract

Zhao

Cai

et al. 2022

BioMed Research International

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This study sought to explore the anticancer mechanism of Picrorhizae Rhizoma (PR) extract based on network pharmacology and molecular docking. The potential chemicals of PR were screened through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and relevant literatures. Corresponding targets of active ingredients were found with the help of the UniProtKB database, and therapeutic targets for cancer action were screened with the help of the GeneCards database. We used Cytoscape software to construct the compound-target-pathway network of PR extract. We utilized the STRING database to obtain the protein-protein interaction (PPI) network. We used DAVID database combining Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Finally, molecular docking was employed for initial efficacy checking. We have identified 16 potential active components of PR through screening, involving 112 disease action targets. Utilizing the GeneCards database, 112 intersecting targets between PR extract and cancer were found, which mainly exerts anticancer effects by regulating tumor necrosis factor (TNF), recombinant caspase 3 (CASP3), c-Jun NH2-terminal kinase (JNK)/JUN, epidermal growth factor receptor (EGFR), and estrogen receptor-1 (ESR1) with some other target genes and pathways associated with cancer. The major anticancer species are prostate cancer, colorectal cancer, small cell lung cancer, etc. In the molecular docking study, herbactin had a strong affinity for TNF. Based on network pharmacology and molecular docking studies, PR and their compounds have demonstrated potential anticancer activities against several key targets. Our preliminary findings provide a strong foundation for further experiments with PR constituents.

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“…For example, by using tumor-derived sEVs as carriers, Moradi-Chaleshtori et al transported miR-130-enriched in sEVs to M2 macrophages, which in turn reduced BC cells proliferation, migration, and invasion (181). In addition, BC stem cells-derived extracellular vesicles (BCSCs-EVs) facilitated epithelialmesenchymal transition (EMT) of BC cells by delivering miR-197 to BC cells and inhibiting PP ARG expression, thereby promoting growth and metastasis of BC cells (182). Interestingly, the chemotherapy-based immunotherapy is emerging as a promising therapeutic approach.…”

Section: Sevs As Potential Therapeutic Targetsmentioning

confidence: 99%

The role and application of small extracellular vesicles in breast cancer

Huang

et al. 2022

Front. Oncol.

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Breast cancer (BC) is the most common malignancy and the leading cause of cancer-related deaths in women worldwide. Currently, patients’ survival remains a challenge in BC due to the lack of effective targeted therapies and the difficult condition of patients with higher aggressiveness, metastasis and drug resistance. Small extracellular vesicles (sEVs), which are nanoscale vesicles with lipid bilayer envelopes released by various cell types in physiological and pathological conditions, play an important role in biological information transfer between cells. There is growing evidence that BC cell-derived sEVs may contribute to the establishment of a favorable microenvironment that supports cancer cells proliferation, invasion and metastasis. Moreover, sEVs provide a versatile platform not only for the diagnosis but also as a delivery vehicle for drugs. This review provides an overview of current new developments regarding the involvement of sEVs in BC pathogenesis, including tumor proliferation, invasion, metastasis, immune evasion, and drug resistance. In addition, sEVs act as messenger carriers carrying a variety of biomolecules such as proteins, nucleic acids, lipids and metabolites, making them as potential liquid biopsy biomarkers for BC diagnosis and prognosis. We also described the clinical applications of BC derived sEVs associated MiRs in the diagnosis and treatment of BC along with ongoing clinical trials which will assist future scientific endeavors in a more organized direction.

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Breast Cancer Stem Cells-derived Extracellular Vesicles Affect PPARG Expression by Delivering MicroRNA-197 in Breast Cancer Cells

Cited by 11 publications

References 32 publications

Breast cancer stem cell-derived extracellular vesicles transfer ARRDC1-AS1 to promote breast carcinogenesis via a miR-4731-5p/AKT1 axis-dependent mechanism

Breast cancer stem cell-derived extracellular vesicles transfer ARRDC1-AS1 to promote breast carcinogenesis via a miR-4731-5p/AKT1 axis-dependent mechanism

Network Pharmacology-Integrated Molecular Docking Reveals the Expected Anticancer Mechanism of Picrorhizae Rhizoma Extract

The role and application of small extracellular vesicles in breast cancer

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