Breast cancer stem cells, EMT and therapeutic targets

Kotiyal, Srishti; Bhattacharya, Susinjan

doi:10.1016/j.bbrc.2014.09.069

Cited by 154 publications

(120 citation statements)

References 47 publications

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“…Loss of Numb leads to unchecked Notch activity, which in cooperation with other pathways may lead to EMT (reviewed in ref. 37). Finally, Numb stabilizes p53 (33).…”

Section: Membrane Traffic Epithelial-tomesenchymal Transition and Camentioning

confidence: 99%

Behind the Scenes: Endo/Exocytosis in the Acquisition of Metastatic Traits

Lanzetti

Fiore

2017

Cancer Research

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Alterations of endo/exocytic proteins have long been associated with malignant transformation, and genes encoding membrane trafficking proteins have been identified as bona fide drivers of tumorigenesis. Focusing on the mechanisms underlying the impact of endo/exocytic proteins in cancer, a scenario emerges in which altered trafficking routes/networks appear to be preferentially involved in the acquisition of prometastatic traits. This involvement in metastasis frequently occurs through the integration of programs leading to migratory/invasive phenotypes, survival and resistance to environmental stresses, epithelial-to-mesenchymal transition, and the emergence of cancer stem cells. These findings might have important implications in the clinical setting for the development of metastasis-specific drugs and for patient stratification to optimize the use of available therapies.

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“…Loss of Numb leads to unchecked Notch activity, which in cooperation with other pathways may lead to EMT (reviewed in ref. 37). Finally, Numb stabilizes p53 (33).…”

Section: Membrane Traffic Epithelial-tomesenchymal Transition and Camentioning

confidence: 99%

Behind the Scenes: Endo/Exocytosis in the Acquisition of Metastatic Traits

Lanzetti

Fiore

2017

Cancer Research

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“…miR-140 is able to target the stem cell factors SOX9 and ALDH to restrict the self-renewal of BCSCs [86]. It is noteworthy that in addition to its critical role in breast tumor cell invasion and metastasis, EMT has been functionally associated with BCSC phenotypes [152]. Therefore, miRNAs involved in regulating EMT are also critical regulators of BCSC phenotypes.…”

Section: The Roles Of Mirnas In Breast Cancer Stem Cells and Drug Resmentioning

confidence: 99%

Noncoding RNAs in breast cancer

Lo¹,

Wolfson²,

Zhou³

et al. 2015

Briefings in Functional Genomics

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The mammalian transcriptome has recently been revealed to encompass a large number of noncoding RNAs (ncRNAs) that play a variety of important regulatory roles in gene expression and other biological processes. MicroRNAs (miRNAs), the best studied of the short noncoding RNAs (sncRNAs), have been extensively characterized with regard to their biogenesis, function and importance in tumorigenesis. Another class of sncRNAs called piwi-interacting RNAs (piRNAs) has also gained attention recently in cancer research owing to their critical role in stem cell regulation. Long noncoding RNAs (lncRNAs) of >200 nucleotides in length have recently emerged as key regulators of developmental processes, including mammary gland development. lncRNA dysregulation has also been implicated in the development of various cancers, including breast cancer. In this review, we describe and discuss the roles of sncRNAs (including miRNAs and piRNAs) and lncRNAs in the initiation and progression of breast tumorigenesis, with a focus on outlining the molecular mechanisms of oncogenic and tumor-suppressor ncRNAs. Moreover, the current and potential future applications of ncRNAs to clinical breast cancer research are also discussed, with an emphasis on ncRNA-based diagnosis, prognosis and future therapeutics.

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“…[26][27][28] It has now been established that breast cancer stem cells (BCSCs) are responsible for metastatic growth in breast cancer which contributes to the majority of breast cancer related mortality. 29,30 A large body of evidence now suggests that the presence of BCSCs is highly associated with specific subtypes. 31,32 Chekhun et al demonstrated that BCSCs are not significantly associated with breast cancer of luminal and HER2-positive subtypes.…”

Section: Cancer Stem Cells and Associated Signaling Pathwaysmentioning

confidence: 99%

Breast cancer lung metastasis: Molecular biology and therapeutic implications

Jin

Han

Siegel

et al. 2018

Cancer Biology & Therapy

232

164

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Distant metastasis accounts for the vast majority of deaths in patients with cancer. Breast cancer exhibits a distinct metastatic pattern commonly involving bone, liver, lung, and brain. Breast cancer can be divided into different subtypes based on gene expression profiles, and different breast cancer subtypes show preference to distinct organ sites of metastasis. Luminal breast tumors tend to metastasize to bone while basal-like breast cancer (BLBC) displays a lung tropism of metastasis. However, the mechanisms underlying this organ-specific pattern of metastasis still remain to be elucidated. In this review, we will summarize the recent advances regarding the molecular signaling pathways as well as the therapeutic strategies for treating breast cancer lung metastasis.

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Breast cancer stem cells, EMT and therapeutic targets

Cited by 154 publications

References 47 publications

Behind the Scenes: Endo/Exocytosis in the Acquisition of Metastatic Traits

Behind the Scenes: Endo/Exocytosis in the Acquisition of Metastatic Traits

Noncoding RNAs in breast cancer

Breast cancer lung metastasis: Molecular biology and therapeutic implications

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