Breast cancer survival by immunohistochemistry-determined subtype: A retrospective study

Valle-Solís, Aura Erazo; Miranda-Aguirre, Arturo Pabel; Mora-Pérez, Josué; Pineda-Juárez, Juan Antonio; Gallardo-Valencia, Luis Ernesto; Santana, Liberio; Cervantes-Sánchez, Guadalupe; Cárdenas-Cárdenas, Eduardo

doi:10.24875/gmm.m19000288

Cited by 1 publication

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References 17 publications

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“…The presence of an ultrasound lesion compatible with a mass or nodule was significantly more frequently present in triple-negative breast tumours compared to luminal and HER2+ subtypes (86% versus 84% versus 68%) [ 20 ]. Lesion size has been a feature highlighted in previous studies, with a median size of 42.5 mm for this tumour subtype, compared to receptor-positive tumours [ 21 ]. Well-demarcated margins in 25% of TNBC and posterior acoustic enhancement are the most frequent presentations found on breast ultrasound [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiological manifestations associated with triple-negative breast cancer in women from northern Peru. A case-control study

Sandoval-Ato,

Coral-Gonzales,

Coronel-Arias

et al. 2024

ecancer Journal

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Objective Triple-negative breast cancer (TNBC) has an aggressive clinical behaviour, with advanced stages at initial diagnostic evaluation, early recurrences and poor survival, so the purpose was to determine the clinical and radiological manifestations associated with TNBC. Materials and methods A case-control study in women diagnosed with breast cancer from January 2015 to August 2022 at the ‘Instituto Regional de Enfermedades Neoplásicas del Norte’. We classified cases (Triple Negative subtype) and controls (Luminal A, Luminal B and HER2) according to immunohistochemistry ical analysis. Bivariate and multivariate logistic regression models were used to calculate the odds ratio (OR) with their respective 95% confidence intervals (CIs). Results The medical reports of 88 cases and 236 controls were reviewed. Cases were more likely to report pain ( p = 0.001), nodules on ultrasound ( p = 0.01) and mammography ( p = 0.003), superior median size ( p < 0.05), posterior enhancement ( p = 0.001) and moderate density ( p = 0.003). Multivariate analysis identified that TNBC was more likely to have a nodular type lesion by ultrasound (OR: 9.73, 95% CI: 1.10–86.16; p = 0.04), ultrasound lesion larger than 36 mm (OR: 4.99, 95% CI: 1.75–14.17; p = 0.003) and moderate density (OR: 3.83, 95% CI: 1.44–10.14; p = 0.007). Conclusion There are particular clinical and imaging manifestations of TNBC, showing that radiological lesions that presented characteristics in ultrasound as nodular type lesions larger than 36 mm and in mammography moderate grade density, were associated with this subtype of breast tumours in a Peruvian population.

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