Breast Cancer Susceptibility Gene in Base Excision Repair Pathway in a Southern Indian Population

Genetic Variants Associated With Response to Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer Patients: A Field Synopsis and Meta‐Analysis

“…One possible mechanism by which the variant allele of XRCC1 rs1799782 protects against PBC chemoresistance is by interfering with the repair of DNA breaks caused by platinum drugs, as the XRCC1 rs1799782 was predicted to be deleterious or damaging by bioinformatics tools. However, other functional studies suggest that allelic substitution of the variant may indirectly affect the stability of XRCC1 via interactions with miRNA and polymerases involved in DNA repair [ 66 , 67 ]. Similarly, the variant allele of XRCC3 rs861539 was also demonstrated to be associated with a protective effect against chemoresistance, consistent with the meta-analysis by Tan et al [ 12 ].…”

Impact of Polymorphism in Base Excision Repair and Nucleotide Excision Repair Genes and Risk of Cervical Cancer: A Case-Control Study

“…However, very little knowledge exists on the association of BER and NER gene polymorphism and cervical cancer susceptibility (Bajpai et al, 2016;Chen et al, 2019;Das et al, 2021). Also, few other Indian studies discovered the positive significance of polymorphism of DNA repair genes with cancer development (Ghosh et al, 2016;Yadav et al, 2018;Nagpal et al, 2020), while other failed to prove significant association (Singh et al, 2016;Datkhile et al, 2017;Nisar et al, 2018;Francis et al, 2018). We observed that 280His and 399Gln of XRCC1 and 326Cys of hOGG1 were collectively involved in CC development, but no evidence for the association of 194Trp of XRCC1 in cervical cancer risk.…”

“…The polymorphisms in NER pathway genes including XPC showed association with risk of prostate (Mandal et al, 2012), head and neck cancer (Yadav et al, 2018). On the other hand, other stated no involvement of either of BER or NER genes with risk of lung (Singh et al, 2016), gastric cancer (Nisar et al, 2018) in North Indian population as well as breast cancer from Western (Datkhile et al, 2017) and Southern Indian population (Francis et al, 2018).…”