Breast carcinoma metastasizing to the cervical esophagus

Biller, Hugh F.; Diktaban, Theodore; Fink, Warren; Lawson, William

doi:10.1288/00005537-198209000-00008

Cited by 17 publications

(7 citation statements)

References 5 publications

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“…The first case of metastasis to the esophagus was reported by Gross and Freedman 4 in 1942 in a patient with prostate cancer. Numerous other reports of individual cases of metastases to the esophagus from a variety of tumors have followed, most of which have involved breast cancer 5 –17 . Borst and Ingold 18 detected only one case (0.04%) of clinically evident esophageal metastasis in 2246 women with ductal breast carcinoma followed over 18 years.…”

Section: Discussionmentioning

confidence: 99%

Direct esophageal metastasis from a distant primary tumor is a submucosal process: a review of six cases

Simchuk

Low

2001

Diseases of the Esophagus

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Malignant esophageal stricture secondary to invasion from a tumor arising in a contiguous organ is a relatively rare finding; even more uncommon is a direct metastasis to the esophagus from a distant primary carcinoma. We present six cases, the largest current series, of esophageal strictures secondary to metastases from a separate primary cancer. We reviewed the records of 20 patients treated at Virginia Mason Medical Center between 1972 and 2000 with a diagnosis of malignant esophageal stricture secondary to an extraesophageal primary carcinoma. Patients whose stricture appeared to be secondary to esophageal invasion or compression from a contiguous tumor or lymph nodes were excluded. The remaining six patients who had metastases to the esophagus itself were reviewed with respect to the nature of the primary tumor, presentation, radiologic and endoscopic findings, and treatment. Among the 20 patients reviewed, 14 were excluded owing to either contiguous involvement from a nearby primary malignancy, regional nodal involvement, or complications of external beam radiation treatment. Six patients were considered to have direct metastasis to the esophagus from distant primary malignancies. The mean age of these patients was 72 years (range 68-74). Two of the primary lesions were lung carcinoma, while four primaries were breast cancers. The average time interval from the diagnosis of a primary tumor to esophageal involvement was 7 years in patients with breast cancer and 5 months in patients with lung cancer. Three patients were palliated with endoscopic dilation and stent placement. The other three patients have died secondary to upper gastrointestinal bleeding. Metastatic cancer to the esophagus is a rare occurrence. The process is usually submucosal and can be difficult to diagnose. The diagnosis should be considered when a patient presents with malignant dysphagia and has a background of distant carcinoma.

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Section: Discussionmentioning

confidence: 99%

Direct esophageal metastasis from a distant primary tumor is a submucosal process: a review of six cases

Simchuk

Low

2001

Diseases of the Esophagus

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“…Tumor metastasis to the esophagus is a rare occurrence, and breast cancer is its most frequent origin (1)(2)(3). Diagnosis of esophageal stricture resulting from metastatic breast cancer is often difficult, and most cases were diagnosed on autopsy and surgery (1,(4)(5)(6)(7)(8)(9)(10). Only some cases have been reported in which endoscopic biopsy confirmed metastatic breast cancer of the esophagus (1,(4)(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

A Case of Esophageal Stricture Due to Metastatic Breast Cancer Diagnosed by Endoscopic Mucosal Resection

Sunada¹,

Yamamoto²,

Kita³

et al. 2005

Japanese Journal of Clinical Oncology

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Metastasis of breast cancer to the esophagus has been reported but is rare. It is often difficult to diagnose metastases of breast cancer to the esophagus because they are often located in the submucosa and covered with normal mucosa. Although several methods have been reported in order to obtain specimens for pathological diagnosis, the adverse effects including bleeding and perforation were considerable problems. We report a case of a patient with esophageal stricture due to metastatic breast cancer to the esophagus. Pathological diagnosis was successfully obtained using endoscopic mucosal resection of the esophagus.

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“…Hematogenous metastases to the esophagus are rare and may occur from cancers of the pancreas, testis, eye, tongue, bone, liver, kidney, uterus, skin, synovium, and prostate [3,[14][15][16][17][18][19][20][21][22][23][24][25]. The present study adds cancers of the cervix, urinary bladder, and breast to this list.…”

Section: Discussionmentioning

confidence: 99%

“…Endoscopy and biopsy specimens of metastatic esophageal tumors usually show normal or inflamed mucosa and are reported to be positive for tumor in only 50% of cases [9,15,17,22,[41][42][43]. Because of the increased incidence of esophageal perforation, some authors do not advocate these procedures for patients with a history of breast carcinoma who present with esophageal symptoms and show radiographic evidence of esophageal involvement [43].…”

Section: Discussionmentioning

confidence: 99%

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Secondary neoplasms of the esophagus

Agha

1987

Gastrointest Radiol

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A review of 62 cases of esophageal involvement by secondary neoplasms is reported. The common routes of esophageal involvement are by direct extension of the tumor from the contiguous or adjacent organs (45.2%), via mediastinal nodes (35.5%), and hematogenous spread from a distant primary (19.3%). In the first 2 modes of esophageal involvement, the diagnosis is usually obvious but hematogenous metastases to the esophagus usually pose a diagnostic challenge. Radiologically, hematogenous metastases show a spectrum of features consisting of a short segment of progressive stricture with normal to minimally irregular mucosa, a submucosal mass with or without ulceration, a polypoid mass or masses, and defects in esophageal motility including secondary achalasia. Since endoscopy and biopsy have limited diagnostic yield, radiologic diagnosis plays a key role in the diagnosis of secondary neoplasms of the esophagus irrespective of their mode of spread to the esophagus.

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Breast carcinoma metastasizing to the cervical esophagus

Cited by 17 publications

References 5 publications

Direct esophageal metastasis from a distant primary tumor is a submucosal process: a review of six cases

Direct esophageal metastasis from a distant primary tumor is a submucosal process: a review of six cases

A Case of Esophageal Stricture Due to Metastatic Breast Cancer Diagnosed by Endoscopic Mucosal Resection

Secondary neoplasms of the esophagus

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