Breast Carcinoma Metastatic to the Choroid

Mewis, Linda; Young, Sue Ellen

doi:10.1016/s0161-6420(82)34838-1

Cited by 133 publications

(85 citation statements)

References 6 publications

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“…1 The incidence of ocular metastases among patients with breast carcinoma in clinical series has been reported to vary between 8 and 10%. 2,3 The occurrence of ocular metastases may not be appreciated because of the dominant clinical picture of metastases in other organs. Treatment options have increased and are prolonging survival, and thereby may increase the possibility of ocular metastases.…”

Section: Introductionmentioning

confidence: 99%

Screening for ophthalmic involvement in asymptomatic patients with metastatic breast carcinoma

Fenton

Kemp

Harnett

2004

Eye

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Background Breast carcinoma metastasises to the eye more frequently than is clinically recognised. The incidence is perhaps not appreciated, either because of the more common involvement and consequences of spread to major organs (such as lung, liver, or bone) or because a number of eye lesions are small and asymptomatic. Over a 6-month period, all patients with locally advanced or metastatic breast cancer were screened for ocular involvement and as a result management recommendations made. Materials and methods Between January 2001 and June 2001, 68 patients with known locally advanced or metastatic breast carcinoma were referred for a screening ophthalmic examination. The aim of the study was to assess the frequency of asymptomatic ocular metastases by breast carcinoma in visually asymptomatic patients. The recognition and early treatment of both ocular metastases and ocular manifestations of metastatic breast carcinoma are important in maximising the quality of life in this group of palliative patients. These patients were all referred and recruited from the Beatson Oncology Centre and Breast Unit at the Western Infirmary, Glasgow by the oncologist (ANH). Examination included visual acuity assessment, slit-lamp examination, tonometry, and indirect ophthalmoscopy. Results The median time from diagnosis of breast carcinoma to ophthalmic screening was 5 years (range 6 months-23 years). No patient had any evidence of choroidal metastases on ophthalmic examination. Four patients (5.8%) had ophthalmic manifestations of metastatic breast carcinoma and a further two had ocular

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Section: Introductionmentioning

confidence: 99%

Screening for ophthalmic involvement in asymptomatic patients with metastatic breast carcinoma

Fenton

Kemp

Harnett

2004

Eye

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“…Uveal metastasis is the most common malignancy of the eye (5,9,23). Early detection and treatment may help avoid significant visual loss and in some cases may even aid in making the primary diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Kreusel et al found that metastasis in more than one organ is a significant risk factor for choroidal metastasis in patients with lung cancer (7). The prognosis following diagnosis of uveal metastasis is poor, with a median survival of 6-9 months (7,(22)(23)(24).…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…Some lesions may show the so-called 'leopard skin' appearance due to the brown pigmentation on their surface secondary to lipofuscincontaining macrophages. In up to 1/3 of the cases, the affected eye may present with more than one focus of metastasis and up to 50% of patients may have bilateral involvement (5,20,23,26) (Fig. 2).…”

Section: Symptoms and Clinical Characteristicsmentioning

confidence: 99%

“…The mechanism of action and associated toxicities depend on the type of agent used. Most of the available data on the use of chemotherapeutic agents for the treatment of uveal metastases are limited to case reports (20,21,23,45). The use of newer therapeutic agents, in particular, has caused tumor size reduction and even complete regression in some cases (46,47).…”

Section: Treatmentmentioning

confidence: 99%

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Uveal metastatic disease: Current and new treatment options (Review)

Giuliari¹,

Sadaka²

2011

Oncol Rep

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Abstract. Choroidal metastasis represents the most common form of intraocular malignancies. It may occur in up to 10% of patients with systemic metastasis with almost half of the patients developing central nervous system disease. The most common primary sites of ocular metastasis are breast cancer in women and lung cancer in men. In most cases, these lesions tend to be asymptomatic and are not evaluated by an ophthalmologist. The diagnosis is generally made by the history of present or prior malignancies and an ophthalmological examination with slit-lamp biomicroscopy and indirect ophthalmoscopy. As with other malignancies, management may vary with each patient. Small tumors, that do not compromise the vision and that have responded previously to systemic treatment, may be closely observed. For larger lesions and for symptomatic ones, external beam radiation offers an excellent alternative to save the eye and stabilize vision. Bevacizumab (Avastin), a potent monoclonal antibody that has also been employed for the treatment of ocular vaso-proliferative diseases, has been used in the treatment of choroidal metastasis and has shown promising results.

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Metastatic Tumors to the Eye and Orbit

Freedman¹

1987

Arch Ophthalmol

236

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Breast Carcinoma Metastatic to the Choroid

Cited by 133 publications

References 6 publications

Screening for ophthalmic involvement in asymptomatic patients with metastatic breast carcinoma

Screening for ophthalmic involvement in asymptomatic patients with metastatic breast carcinoma

Uveal metastatic disease: Current and new treatment options (Review)

Metastatic Tumors to the Eye and Orbit

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