Breast Carcinoma with Choriocarcinomatous Differentiation; a Rare Case

Abstract

Objectives: Breast carcinoma with choriocarcinomatous differentiation is a rare entity, generally presenting with high--grade disease and an aggressive clinical course with overall survival of less than a yearCase: A 69--year--old woman with a diagnosis of pT1N0M0 invasive ductal carcinoma with choriocarcinomatous differentiation received six cycles of adjuvant chemotherapy and is still disease free on the 23rd month after diagnosis, showing a better prognosis than most other cases reported in the literature. Conclusion:The reason for the poor prognosis for this type of breast carcinoma remains unclear.Standard chemotherapeutic agents administered for breast carcinoma may be used for choriocarcinomatous differentiation.

Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cure

“…On gross examination, the tumor generally appears well circumscribed with hemorrhagic and necrotic components, similar to choriocarcinoma with breast metastasis. Typically, the choriocarcinomatous cells are associated with hemorrhage and necrosis in a background of either invasive ductal carcinoma or ductal carcinoma in situ ( 6 ). Choriocarcinomatous cells have been described as multinucleated, giant bizarre looking cells resembling syncytiotrophoblastic and cytotrophoblastic cells ( 7 ).…”

“…BCCF must also be differentiated from metastatic choriocarcinoma to the breast. Patients with metastatic choriocarcinoma typically have a history of reproductive tumors and a primary breast tumor is not present ( 6 ). While uncommon, trophoblastic cancers can metastasize to the breast.…”