Breast conservation therapy decreased heart-specific mortality in breast cancer patients compared with mastectomy

Abstract

Aim To investigate the impacts of breast conservation therapy (BCT) and mastectomy on heart-specific mortality in breast cancer patients. Methods Patients with primary breast cancer registered in the Surveillance, Epidemiology, and End Results (SEER) database between Jan 1998 and Dec 2015 were included. Patients were divided into either breast conservation therapy or mastectomy group. To compare mortality caused by heart diseases in breast cancer patients with BCT or mastectomy, univariate and multivariate regression after propensity score matching (PSM) were performed. Kaplan-Meier analysis was also used to evaluate heart-specific survival between two groups. Results 132,616 patients with breast cancer were enrolled in this study. After PSM, four risk factors including age, race, marital status and types of surgery were identified significantly associated with death from heart diseases. Heart-specific survival analysis further showed that overall, BCT poses a lower risk to heart-specific mortality compared with mastectomy. Conclusion Compared with mastectomy, BCT significantly decreased heart-specific mortality in breast cancer patients.

Breast-conserving surgery is an appropriate procedure for centrally located breast cancer: a population-based retrospective cohort study

“…However, we need to be aware that central breast cancer may have the potential to invade the wider breast ducts [ 8 , 9 ]. Considering the cosmetic appearance and local control, tumor size is an important factor associated with the selection of BCS in clinical practice, which is supported by several guidelines and consensuses [ 1 , 2 , 26 ]. Several small sample, short-term follow-up studies based on the SEER database have enrolled some T3-4 or stage III/IV disease which would influence the application of research results [ 14 , 15 , 17 , 18 ].…”