Breast-conserving therapy for Stage I-II synchronous bilateral breast carcinoma

Gollamudi, Smitha; Gelman, Rebecca; Peiró, Gloria; Schneider, Lindsey; Schnitt, Stuart J.; Recht, Abram; Silver, J B A Barbara; Harris, Jay R.; Connolly, James L.

doi:10.1002/(sici)1097-0142(19970401)79:7<1362::aid-cncr14>3.0.co;2-y

Cited by 66 publications

(59 citation statements)

References 17 publications

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“…Thus, the much stronger increase in mortality over time among women with bilateral cancer younger than age 50 years compared with women with unilateral disease suggests that chemotherapy exerts a stronger sel ection pressure than adjuvant endocrine treatment. [6,7,8] In present case patient was on chemotherapy and follow up later was not possible as patient was not traceable .…”

Section: Discussionsupporting

confidence: 78%

Synchronus Bilateral Breast Carcinoma (SBBC): A cytological diagnosis with review of literature

Javalgi

Arakeri

arora

2014

Int Jour of Biomed Res

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Section: Discussionsupporting

confidence: 78%

Synchronus Bilateral Breast Carcinoma (SBBC): A cytological diagnosis with review of literature

Javalgi

Arakeri

arora

2014

Int Jour of Biomed Res

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“…Synchronous breast cancers have been variedly defined as two tumours diagnosed with in an interval of 1 month [1], 2 months [2], 3 months [3], 6 months [4] or 1 year [5]. Accordingly the incidence of SBC has been varying in different series.…”

Section: Introductionsupporting

confidence: 91%

Synchronous Bilateral Breast Cancers

Padmanabhan

Subramanyan

Selvi

2015

JCDR

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IntrOductIOnBilateral breast cancer (BBC) is not an uncommon entity in contemporary breast clinics. We have an increasing incidence of BBC as a result of improved life expectancy after breast cancer treatment and routine use of contra-lateral breast mammography in newly diagnosed breast cancers. Lobular cancer in the index breast, family history of breast cancer, young age at diagnosis of first cancer and BRCA mutations are important risk factors that are known to be at increased risk for BBC. [5]. Accordingly the incidence of SBC has been varying in different series. Controversies also exist about the origin of second cancer (metastatic spread or independent primary) and its prognostic significance. More often than not, women with BBC are treated with most radical surgeries based on the notion that these tumours are biologically aggressive. However, scientific evidence for this belief is divided. There is no population based or large sample size studies analysing the survival outcomes of BBC in Indian women. The objective of this study was to define the epidemiological and tumour characteristics of bilateral breast cancer in India. Here in this study we analysed the clinical and pathologic characteristics, treatment parameters and outcome of BBC in Indian women from a single institution cohort. mAterIAls And metHOdsWe examined a consecutive cohort of breast cancer patients treated at our center between January 2007 to March 2015. A total of 1251 breast cancer patients were treated during this period. Clinical details were prospectively collected which include patient characteristics, tumour pathology, treatment variables, disease free survival and date of death. Patients were followed up with routine clinical examination, annual mammogram and other investigations if required.In this period 30 patients were found to have BBC which constituted the study population. This study was approved by institutional ethical committee and informed consent was obtained from all the patients who were included in the study. Synchronous bilateral breast cancers (SBC) was defined as two tumours diagnosed within an interval of 6 months and a second cancer diagnosed after 6 months was labelled as metachronous breast cancer (MBC). A patient was considered to have positive family history when a first degree relative had a history of breast cancer. Analyses of various patient and tumour characteristics were done in this prospective data base of BBC patients. resultsOverall 30 patients had BBC during the study period and majority were synchronous tumours (93.3%; n=28). Most patients with synchronous tumours (n=25) had their second cancers diagnosed during the initial presentation. Three SBC patients had their contralateral cancers diagnosed during 3, 4 and 6 months after the first tumour. Two cases of MBC were diagnosed 16 and 54 months after the first tumour [Table/ Fig-1]. Infiltrating ductal carcinoma was the commonest histological type (n =51) followed by DCIS, lobular and papillary types (n=7, 1, 1 respectively). DCIS was present...

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“…Moreover, measurable morbidity rates and negative psychological impacts were found to be associated with prophylactic mastectomy [39,40]. Secondly, BCT was described as a safe and efficacious treatment option for treating early stage cancer [11,27,41,42]. studies have demonstrated no significant increase risk of contralateral breast cancer after radiation treatment for initial tumour [43][44][45], while others documented the opposite [46][47][48].…”

Section: Discussionmentioning

confidence: 99%