Breast Ductal Carcinoma in Situ

Coleman, William B.

doi:10.1016/j.ajpath.2019.03.002

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…The differentiation of suspicious calcifications between DCIS and benign breast disease is clinically important for early diagnosis and treatment, resulting in a better prognosis and decreased recurrence rate. 5,22 According to previous studies, most DCIS cases are frequently detected at screening mammography. 3,4 The current study also showed that both DCIS and benign breast disease patients were asymptomatic and first noticed on screening examinations.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 The early detection of DCIS could change disease prognosis and treatment options. 5 Breast microcalcifications, which are the main presentations of asymptomatic breast malignancies, account for 50% -75% of mammographic findings. 6,7,8 Breast microcalcifications may represent diverse pathological processes including inflammation, infection, benign tumour and malignancy.…”

Section: Introductionmentioning

confidence: 99%

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Mammography of suspicious calcifications among ductal carcinoma in situ and benign breast disease

Lohitvisate,

Kaeorat,

Kwankua

2024

South African Journal of Radiology

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Background: Most ductal carcinoma in situ (DCIS) lesions manifest early as calcifications, which could be benign or malignant. The classified group of suspicious calcifications among DCIS and benign breast disease is clinically important to early evaluate patient risk factors and plan treatment options.Objectives: To compare imaging features of suspicious calcifications between DCIS and benign breast disease.Method: A retrospective study of 101 suspicious calcifications was performed at Thammasat University Hospital from June 2011 to October 2020. The calcifications were surgically excised by mammography-guided wire localisation. The mammographic features of the suspicious calcifications were reviewed according to the fifth edition of the American College of Radiology Breast Imaging-Reporting and Data System lexicon. For comparing between two groups, the student t-test, Fisher’s exact test and Mann-Whitney U test were used for statistical analyses. The logistic regression analysis was calculated for DCIS prediction.Results: The pathologic results of all 101 suspicious calcifications were DCIS (30 cases) and benign breast disease (71 cases). Linear morphology and segmental distribution correlated significantly with DCIS (p = 0.003 and p = 0.024, respectively). After multivariable analysis, fine linear calcification still significantly elevated the risk of DCIS (odd ratios, 51.72 [95% confidence interval: 2.61, 1022.89], p-value of 0.01), however, the odds of predicting DCIS was not statistically significant different among any distribution.Conclusion: Ductal carcinoma in situ calcification has contrasting morphology and distribution features compared to benign breast disease. The calcification descriptor is considered an important implement for early diagnosis and distinguishes DCIS from other benign breast conditions.Contribution: Calcification descriptor is considered an important implement for early diagnosis and distinguishment of DCIS from other benign breast conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mammography of suspicious calcifications among ductal carcinoma in situ and benign breast disease

Lohitvisate,

Kaeorat,

Kwankua

2024

South African Journal of Radiology

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“…El CDIS de mama se define como un conglomerado de células epiteliales anormales, las cuales se presumen como células malignas, y que se encuentran confinadas en los ductos y lóbulos mamarios sin invadir la membrana basal ni las células mioepiteliales que rodean el sistema ductolobulillar mamario (5). En otras palabras, el CDIS se refiere a todas aquellas células epiteliales mamarias que se vuelven "cancerígenas", pero que a su vez residen en su lugar habitual dentro de los ductos y lóbulos mamarios (6).…”

Section: Definiciónunclassified

“…Sin embargo, la mayoría de las lesiones del CDIS se clasifican como "no específicas". En comparación con otros subtipos, los CDIS de tipo comedo son lesiones de alto grado y con abundante proliferación celular (5).…”

Section: Subtipos Histológicosunclassified

Carcinoma ductal in situ de mama

Montagné-Bonilla,

Soto-Harvey,

Huete-Echandi

2024

Rev.méd.sinerg.

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El carcinoma ductal in situ (CDIS) de mama se define como un conglomerado de células epiteliales anormales, las cuales se presumen como células malignas, y que se encuentran confinadas en los ductos y lóbulos mamarios sin invadir la membrana basal ni las células mioepiteliales que rodean el sistema ductolobulillar mamario. No existen manifestaciones clínicas específicas del CDIS. La mayoría de pacientes se presentan con una mamografía anormal, asintomáticas y sin hallazgos al examen físico. Más del 90% de todos los casos de CDIS son detectados únicamente por imágenes, y posteriormente se confirma el diagnóstico por medio de una biopsia. La cirugía conservadora de mama es generalmente el tratamiento de preferencia. Afortunadamente, el CDIS tiene pronóstico excelente con adecuado tratamiento multidisciplinario.

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“…As opposed to breast carcinomas in situ, invasive breast carcinomas have the capability to invade the mammary stroma, vascularize, and metastasize [33,79]. The invasive and capability of cancer cells is dramatically influenced by the TME, which consists of non-cancer stromal cells, blood vessels, lymphatic tumor vessels, and ECM [12,14,18,21,26].…”

Section: Hallmarks Of Metastatic Bcmmentioning

confidence: 99%

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination

Avagliano

Fiume

Ruocco

et al. 2020

Cancers

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The stromal microenvironment regulates mammary gland development and tumorigenesis. In normal mammary glands, the stromal microenvironment encompasses the ducts and contains fibroblasts, the main regulators of branching morphogenesis. Understanding the way fibroblast signaling pathways regulate mammary gland development may offer insights into the mechanisms of breast cancer (BC) biology. In fact, the unregulated mammary fibroblast signaling pathways, associated with alterations in extracellular matrix (ECM) remodeling and branching morphogenesis, drive breast cancer microenvironment (BCM) remodeling and cancer growth. The BCM comprises a very heterogeneous tissue containing non-cancer stromal cells, namely, breast cancer-associated fibroblasts (BCAFs), which represent most of the tumor mass. Moreover, the different components of the BCM highly interact with cancer cells, thereby generating a tightly intertwined network. In particular, BC cells activate recruited normal fibroblasts in BCAFs, which, in turn, promote BCM remodeling and metastasis. Thus, comparing the roles of normal fibroblasts and BCAFs in the physiological and metastatic processes, could provide a deeper understanding of the signaling pathways regulating BC dissemination. Here, we review the latest literature describing the structure of the mammary gland and the BCM and summarize the influence of epithelial-mesenchymal transition (EpMT) and autophagy in BC dissemination. Finally, we discuss the roles of fibroblasts and BCAFs in mammary gland development and BCM remodeling, respectively.

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Breast Ductal Carcinoma in Situ

Cited by 11 publications

References 25 publications

Mammography of suspicious calcifications among ductal carcinoma in situ and benign breast disease

Mammography of suspicious calcifications among ductal carcinoma in situ and benign breast disease

Carcinoma ductal in situ de mama

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination

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