Objective: to highlight the knowledge of female medical students about breastfeeding in general and in special situations. Subjects and methods: A descriptive cross-sectional study on female medical students enrolled in the academic year 2011/2012 in Mansoura Faculty of Medicine from first to final years using self-administered questionnaire. Results: A total of 631students participated with 258 in the preclinical and 373 in the clinical grades. Generally, the majority of students were more aware about initiation, duration and advantages of breastfeeding than correct breastfeeding practice in some special situations. Conclusion: Educational stage is a significant variable in the level of knowledge and medical students and the joiner year's curricula must include more knowledge about breastfeeding.