Breast feeding and early life immunomodulation

Feliciano, Laura San; Matías, Vanesa; Lapeña, Santiago; Fernandez, J. Escribano; Ardura, J; Soga, Maria José; Remesal, Ana; Marugán-Isabel, Victor; Hernandez-Gonzalez, Natalio; Iglesias, Verónica; Lejarazu, Raúl Ortíz de; Bermejo-Martín, Jesús F.

doi:10.1111/pai.12003

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…In keeping with that notion, breastfeeding is an environmental exposure with a prominent role in the regulation of neonatal innate immune responses (2,3). A potential allergymanipulating effect of breastfeeding has been the target of rigorous research ever since 1936, when Grulee and Sanford first reported it to protect from infantile eczema.…”

mentioning

confidence: 99%

Breastfeeding and wheeze prevalence in pre‐schoolers and pre‐adolescents: the Genesis and Healthy Growth studies

Guibas

Xepapadaki

Moschonis

et al. 2013

Pediatric Allergy Immunology

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confidence: 99%

Breastfeeding and wheeze prevalence in pre‐schoolers and pre‐adolescents: the Genesis and Healthy Growth studies

Guibas

Xepapadaki

Moschonis

et al. 2013

Pediatric Allergy Immunology

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“…It is therefore important to obtain clinical information about the patients at the time of sampling. The influences 88 , breastfeeding 89,90 , environmental factors and genetic polymorphisms on TLRs and downstream signaling pathways 61,91,92 remain unknown. In addition to these factors, physicians also need to be aware of underlying diseases such as cancers, immunosuppression and chronic inflammatory conditions, which may also affect the results.…”

Section: Discussionmentioning

confidence: 98%

Addressing diagnostic challenges in primary immunodeficiencies: Laboratory evaluation of Toll-like receptor- and NF-κB-mediated immune responses

Frans

Meyts

Pïcard

et al. 2014

Critical Reviews in Clinical Laboratory Sciences

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Toll-like receptors (TLRs) play an important role in immunity and mediate their actions via multiple signaling pathways, in particular, the nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-κB) pathway. Rare inherited defects of TLR- and NF-κB-dependent responses have recently been recognized. These primary immunodeficiencies predispose children to life-threatening infections and often remain undiagnosed. Establishing a sensitive, specific, cost-effective and simple method for diagnosis is therefore important. In this article, we review the known defects of TLR- and NF-κB-mediated pathways and the assays that can be used to screen for such defects.

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“…The authors withhold a recommendation for or against breastfeeding, but underline the importance of the ” harmonization of features of study design” [ 57 ]. By contrast, two other studies emphasize the potential protective effect of breastfeeding against allergies, as the specific neonatal innate immune function was associated with breastfeeding [ 58 ] and its duration was associated with the levels of IL-10 and RANTES secreted by the upper respiratory tract of preterm children 1 year after birth [ 59 , 60 , 61 ].…”

Section: Breast-feeding Maternal and Infant Dietmentioning

confidence: 99%

Prevention of allergies in childhood – where are we now?

Ahrens

Posa

2017

ALS

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Allergic diseases represent an increasing health problem for children worldwide. Along with allergic airway diseases, food allergy comes to the fore and herewith closely intertwined the hypothesis that an early allergic sensitization might occur via skin barrier defect(s). The importance of the skin barrier has been documented by several studies meanwhile. Not only genetic studies screen the associations between Filaggrin loss-of-function mutations, atopic dermatitis, allergic sensitization, food allergy and even airway diseases, but also epidemiological studies cast new light on the hypothesis of the atopic march. As another focus in context of the development of an allergic phenotype, the specific microbial exposure with all its diversities has been crystallized as it shapes the immune system in (early) infancy. Studies explored both, the role of human intestinal microbiota as well as the external microbial diversity. Unfortunately suitable markers for atopic predictors are still rare. New studies point out that specific IgE antibodies (e.g., IgE to Phl p 1) in children without allergic symptoms so far, might function as a pre-clinical biomarker, which may help to identify candidates for primary (allergen non-specific) or secondary (allergen-specific) prevention in terms of specific immunoprophylaxis. These manifold research activities document a complex increase in knowledge. Nevertheless new assumptions need to be substantively confirmed in order to finally generate the urgently needed preventive strategies for allergic diseases in childhood.

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Breast feeding and early life immunomodulation

Cited by 4 publications

References 5 publications

Breastfeeding and wheeze prevalence in pre‐schoolers and pre‐adolescents: the Genesis and Healthy Growth studies

Breastfeeding and wheeze prevalence in pre‐schoolers and pre‐adolescents: the Genesis and Healthy Growth studies

Addressing diagnostic challenges in primary immunodeficiencies: Laboratory evaluation of Toll-like receptor- and NF-κB-mediated immune responses

Prevention of allergies in childhood – where are we now?

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