Breast hamartoma: A report of 14 cases of an under-recognized and under-reported entity

Amir, Rawan; Sheikh, Salwa S.

doi:10.1016/j.ijscr.2016.03.007

Cited by 22 publications

(28 citation statements)

References 11 publications

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“…[ 19 ] But syringomatous adenoma locates in the nipple-areolar complex, whereas LGASC occurs within breast parenchyma. Myoid hamartoma is composed of varying amounts of smooth muscle cells, mammary ducts, lobules, fibrous tissue, and adipose tissue [ 22 ] ; in contrast, LGASC does not contain smooth muscle cells. Squamous metaplasia can also detected in breast pleomorphic adenoma (PA).…”

Section: Discussionmentioning

confidence: 99%

Expression of hormone receptors in low-grade adenosquamous carcinoma of the breast

Wu¹,

Zhang²,

Wang

et al. 2017

Medicine

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Rationale:Low-grade adenosquamous carcinoma (LGASC) is a rare subtype of metaplastic breast carcinoma which is generally recognized as a characteristic subgroup of triple-negative breast cancers previously. However, in this study, we reported for the first time a case of LGASC with hormone receptors expression.Patient concerns:Pathological analysis of breast tumor specimen obtained by a 42-year-old female patient was performed. Morphologically, it composed of glandular structures with scattered squamous differentiation accompanied by haphazard arrangement of spindle cell stroma. Immunohistochemically, all myoepithelial and squamous differentiation markers showed typical LGASC positive or negative staining pattern. Interestingly, we found that normally aberrant hormone receptors were reactivated in this case. To our knowledge, this is the first report of a hormone receptor-positive LGASC. Apart from this, in the extended resection sample, we found scattered squamous metaplasia and florid adenosquamous proliferation (ASP). Meanwhile, it was positive for CD44 variant isoforms (CD44v), which is a breast cancer stem cell (CSC) marker, and expressed in LGASC, squamous metaplasia, and ASP.Diagnosis:LGASC with hormone receptors expression.Interventions:The breast-extended local excision and axillary lymph node dissection were performed.Outcomes:The patient was free of local recurrence and distant metastasis 6 months after surgical resection.Lessons:We herein report the first case of LGASC with immunoreactivity for hormone receptors, expanding its profile of immunophenotypes. CD44v may play an important role in the transition of LGASC precursor lesions into malignant processes, which may serve as a therapeutic target in LGASC.

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Section: Discussionmentioning

confidence: 99%

Expression of hormone receptors in low-grade adenosquamous carcinoma of the breast

Wu¹,

Zhang²,

Wang

et al. 2017

Medicine

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“…Despite its irregularity and disorganization, there is no malignant tissue interweaved within normal elements. However, in a study of 14 breast hamartomas in both males and females, one was found to have irregular borders and three showed myoid differentiation [10]. Myoid hamartomas belong to an uncommon subtype of breast hamartoma with low recurrence [11].…”

Section: Discussionmentioning

confidence: 99%

A Male Patient With Breast Hamartoma: An Uncommon Finding

Phan¹,

Nguyen²,

He³

et al. 2020

Cureus

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Mammary hamartoma is a rare type of breast tumor that is composed of the same elements as normal mammary tissue. This condition is very rare in men. In current literature, there are fewer than five case reports on male breast hamartoma. This benign pathology is underreported because of several reasons. Since breast tumors are still considered an exclusively female diagnosis and statistically proven to be gynecomastia when arising in men, they are often overlooked. In addition to the uncommon clinical presentation in men, insufficiency of definitive pathologic and radiologic characteristics can make an accurate diagnosis a challenging task. Mammary hamartoma is a benign condition with an excellent prognosis. The following case describes a rare instance of an enlarging mammary hamartoma in a male patient, highlighting the imaging features, pathohistological findings, and clinical management.

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“…Clinically, breast hamartomas are indistinguishable from the more common fibroadenomas or fibrocystic breast disease. 6 However, the histological features are distinct, likely reflecting different origins. Histologically, they are characterised by densely packed enlarged lobules set within a fibrous stroma.…”

Section: Answermentioning

confidence: 99%

“…In the adult population, there have been few reported cases of recurrence or malignancy arising from breast hamartomas, and it is speculated that recurrent lesions may in fact represent multifocal disease rather than true recurrence. 6,10 Overall there is a scarcity of literature documenting breast hamartomas in the paediatric population. Given the propensity for miscategorisation, the true incidence is likely to be higher than is currently indicated in the literature.…”

Section: Answermentioning

confidence: 99%