Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) in axillary lymph nodes – a case report and review of 29 other cases from world literature

Dymek, Przemysław; Błaszkowski, Tomasz; Sienkiewicz, Sandra; Kiełbowski, Kajetan; Mruk, Honorata; Lewandowska, Magdalena; Kipczak, Aleksandra; Szyld, Maciej; Kładny, Józef

doi:10.5603/njo.a2020.0044

Cited by 2 publications

(4 citation statements)

References 13 publications

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Section: Discussionmentioning

confidence: 99%

“…The fact that the lymphoma developed 2 years after the removal of the implants and the cancer occurred in the axillary lymph nodes suggests that migration of silicones to the lymph nodes can be a risk and must be taken seriously. 32 BIA-ALCL is an emerging and important medical challenge. The pathogenesis of BIA-ALCL has not been fully established so far, and there are several theories, of which silicone toxicity is one.…”

Section: Discussionmentioning

confidence: 99%

“…Natural killer cell activity is known to decrease significantly in women with SBIs, thereby inhibiting the clearing of the silicones, and it is also thought that patients with decreased natural killer cell activity have an increased risk of cancer . In a case report, a patient aged 46 years was diagnosed with BIA-ALCL 2 years after her implants were removed. The fact that the lymphoma developed 2 years after the removal of the implants and the cancer occurred in the axillary lymph nodes suggests that migration of silicones to the lymph nodes can be a risk and must be taken seriously …”

Section: Discussionmentioning

confidence: 99%

“…In a case report, a patient aged 46 years was diagnosed with BIA-ALCL 2 years after her implants were removed. The fact that the lymphoma developed 2 years after the removal of the implants and the cancer occurred in the axillary lymph nodes suggests that migration of silicones to the lymph nodes can be a risk and must be taken seriously …”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Assessment of Silicone Particle Migration Among Women Undergoing Removal or Revision of Silicone Breast Implants in the Netherlands

2021

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Key Points Question Are cohesive gel breast implants associated with silicone bleed? Findings In this case series including 389 women with silicone gel breast implants, 384 women (98.8%) showed silicones in the tissues. There was no statistically significant difference between women with cohesive gel implants and those with noncohesive gel implants. Meaning These findings suggest that cohesive silicone gel breast implants leak silicones and may potentially harm patients, as noncohesive gel implants do.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of Silicone Particle Migration Among Women Undergoing Removal or Revision of Silicone Breast Implants in the Netherlands

2021

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A Prospective Observational Clinical Cohort of Women with Suspected Breast Implant Illness

Spit,

Azahaf,

de Blok

et al. 2024

JCM

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Background: This study aims to describe a prospective clinical cohort of patients with silicone breast implants and suspected Breast Implant Illness (BII). Methods: Women were included in a specialized silicone outpatient clinic at Amsterdam UMC, the Netherlands. Baseline characteristics were collected including medical history, implant details, and symptoms. Experienced physicians categorized BII suspicion as high, moderate, or low, based on symptoms and after exclusion of other probable causes. Additionally, participants completed questionnaires assessing symptoms and daily life impact at baseline, 6 months, 1, 2, and 5 years. For this initial analysis, the results from the first three years of inclusions were collected. Results: Data from 353 women were collected from December 2020–December 2023. At baseline, the most reported symptoms were fatigue, arthralgia, myalgia, and morning stiffness, accompanied by local symptoms in 83.3% of patients. At the clinic, 112 women were categorized as having high suspicion of BII, 147 women as moderate, and 94 women as low. At follow-up, 182 women (51.6%) opted for explantation. Following explantation, women with a high or moderate suspicion of BII experienced more significant symptom improvement, accompanied by a decrease in anxiety and a greater sense of control over their illness, compared to women with a low suspicion of BII. Conclusions: Our study highlights a distinct interplay of systemic and local symptoms among women with suspicion of BII. Women with a high or moderate BII suspicion benefit significantly more from explantation than women with low suspicion. Experienced physicians are pivotal in effectively assessing and guiding this patient group, highlighting the need for tailored clinical approaches.

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Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) in axillary lymph nodes – a case report and review of 29 other cases from world literature

Cited by 2 publications

References 13 publications

Assessment of Silicone Particle Migration Among Women Undergoing Removal or Revision of Silicone Breast Implants in the Netherlands

Assessment of Silicone Particle Migration Among Women Undergoing Removal or Revision of Silicone Breast Implants in the Netherlands

A Prospective Observational Clinical Cohort of Women with Suspected Breast Implant Illness

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