Breast Implants and Breast Cancer: A Review of Incidence, Detection, Mortality, and Survival

Deapen, Dennis

doi:10.1097/01.prs.0000286577.70026.5d

Cited by 52 publications

(24 citation statements)

References 84 publications

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“…Although the use of breast implants has no correlation with the risk for BC, their presence lowers the effectiveness of mammogram testing, thus contributing to delayed diagnosis [10,11]. Therefore, women who consider breast implants ought to be informed about that risk.…”

Section: Diagnostic Testingmentioning

confidence: 99%

Breast cancer in young women

Radecka¹,

Litwiniuk²

2016

Ginekol Pol

119

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Breast cancer (BC) in young women is rare, affecting only 4-6% of women under the age of 40. Regardless, BC remains the most common malignancy among younger patients. Recently, a significant increase in BC rates has been observed among pre-menopausal subjects. Breast cancer in young women requires special attention due to its specific morphologic and prognostic characteristics and unique aspects, including fertility preservation and psychosocial issues (e.g. its impact on family life and career). Young women are more likely to have tumors with higher incidence of negative clinicopathologic features (higher histological grade, more lymph node positivity, lower estrogen receptor (ER) positivity, higher rates of Her2/neu overexpression). Also, they tend to be diagnosed at more advanced stages of the disease. That, in turn, contributes to less favorable prognosis as compared to older women. Young women are generally treated similarly to older patients. Surgical management includes mastectomy or breast-conserving surgery, followed by radiation therapy (younger women have higher local recurrence rates than older women, especially after breast-conserving therapy). Although the basics of chemotherapy are the same for patients of all ages, younger women have some special considerations. It is important to consider options for fertility preservation before starting systemic treatment. Patients should have access to genetic testing as their results may affect the choice of therapy. Younger women and their families should receive adequate psychological support and counselling.

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Section: Diagnostic Testingmentioning

confidence: 99%

Breast cancer in young women

Radecka¹,

Litwiniuk²

2016

Ginekol Pol

119

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“…It is usually caused by malignant proliferation of mammary gland cells or acinar cells (Deapen, 2007). The incidence of breast cancer has risen markedly in most countries recently.…”

Section: Introductionmentioning

confidence: 99%

S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation

Sun

2015

Genet. Mol. Res.

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ABSTRACT. We investigated the expression of S-phase kinaseassociated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2 in breast cancer patient tissues and normal breast tissues was detected by western blotting analysis and reverse transcription-polymerase chain reaction. SKP2-specific siRNA was used to decrease SKP2 expression in breast cancer cell line MDA-MB-231. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to detect cell proliferation. SKP2 expression in breast cancer tissues was significantly higher than in normal breast tissues (P < 0.05). Two pairs of siRNA specific to SKP2 were required to downregulate SKP2 expression in the breast cancer cell line MDA-MB-231. The MTT assay showed that MDA-MB-231 growth significantly slowed after SKP2 interference. Patients with breast cancer have an increased 9245 SKP2 expression and breast cancer cell proliferation ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9244-9252 (2015) SKP2 level. Interference in SKP2 gene expression can inhibit breast cancer cell growth, suggesting that SKP2 is potentially a new target for breast cancer therapy.

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“…The results of these studies were conflicting which can be attributed, at least in part, to methodologic issues (18). Only 3 publications, including our previous report, showed a statistically significant shift toward more advanced breast tumors at diagnosis among augmented women (19)(20)(21).…”

Section: Introductionmentioning

confidence: 74%

Do Breast Implants Adversely Affect Prognosis among Those Subsequently Diagnosed with Breast Cancer? Findings from an Extended Follow-Up of a Canadian Cohort

Lavigne

Holowaty

Pan

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Cosmetic breast implants may impair the ability to detect breast cancers. The aims of this study were to examine whether implants and implant characteristics are associated with more advanced breast tumors at diagnosis and poorer survival.Methods: Study population includes all invasive breast cancer cases diagnosed during follow-up of the large Canadian Breast Implant Cohort. A total of 409 women with cosmetic breast implants and 444 women with other cosmetic surgery were diagnosed with breast cancer. These women were compared for stage at diagnosis using multinomial logistic regression models. Cox proportional hazards regression models were used for breast cancer-specific mortality analyses. Comparisons were also conducted according to implant characteristics.Results: Compared with women with other cosmetic surgery, those with cosmetic breast implants had at later stage breast cancer diagnosis (OR of having stage III/IV vs. stage I at diagnosis: 3.04, 95% confidence interval (CI): 1.81-5.10; P < 0.001). A nonstatistically significant increase in breast cancer-specific mortality rate for women with breast implants relative to surgical controls was observed (HR ¼ 1.32, 95% CI: 0.94-1.83, P ¼ 0.11). No statistically significant differences in stage and breast cancer mortality were observed according to implant characteristics.Conclusions: At diagnosis, breast cancers tended to be at more advanced stages among women with cosmetic breast implants. Breast cancer-specific survival was lower in these women although the reduction did not reach statistical significance.Impact: Further investigations of the effect of breast implants on breast cancer prognosis are warranted. Cancer Epidemiol Biomarkers Prev; 21(10); 1868-76. Ó2012 AACR.

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Breast Implants and Breast Cancer: A Review of Incidence, Detection, Mortality, and Survival

Cited by 52 publications

References 84 publications

Breast cancer in young women

Breast cancer in young women

S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation

Do Breast Implants Adversely Affect Prognosis among Those Subsequently Diagnosed with Breast Cancer? Findings from an Extended Follow-Up of a Canadian Cohort

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