The false positive and false negative rates of current image localization methods in gynecological lesion area are high because the effectiveness is affected by random noise. Therefore, by using Bhattacharyya coefficient-based scale-invariant feature transform (B-SIFT), a novel localization method of lesion area in gynecological ultrasound image is proposed in this paper. Firstly, Rayleigh mean filtering is used to suppress the noise in the ultrasound image based on Rayleigh distribution characteristics of the noise. Then, the segmentation method of the lesion region is designed by using the scale-invariant feature transform (SIFT). Furthermore, the feature extraction function B-SIFT is proposed to locate the lesion region based on the Bhattacharyya coefficient. Finally, two lesion characteristics of Bhattacharyya coefficients are defined, and the B-SIFT-based feature region descriptors are obtained by constructing an eigenvector normalized based on the Bhattacharyya coefficients. Experimental results show that the proposed method has a high positioning accuracy, strong recall ratio, low energy consumption, and low time consumption, which is more effective and feasible than the traditional method for localization of lesions.