Breast lymphoma in a patient with B-cell Non Hodgkin Lymphoma: A case report study

Abstract

HighlightsBreast involvement in Non Hodgkin Lymphoma is a rare entity.Breast lymphomas represent localized extranodal Primary or Secondary lymphomas.Physical examination is paramount for discovering lesions.Preoperative diagnosis ensures avoidance of unnecessary interventions.Breast lymphomas should be considered in the differential diagnosis of breast neoplasms.

A Case Series of Breast Metastases from Different Extramammary Malignancies and Their Literature Review

“…Breast lymphoma is a very rare entity, accounting for only 0.1%–0.5% of all breast cancer cases [29, 30]. Further, 0.38%–0.7% of all non-Hodgkin lymphomas (NHL) and 1.7%–2.2% of extranodal NHL cases result in breast metastases [29].…”

“…Further, 0.38%–0.7% of all non-Hodgkin lymphomas (NHL) and 1.7%–2.2% of extranodal NHL cases result in breast metastases [29]. The histological type is predominantly B-cell lymphoma, accounting for 85%–95% of all cases, followed by T-cell, Burkitt, mucosa-associated lymphoid tissue lymphoma (MALT), and extranodal natural killer lymphoma nasal types (ENKTL) affecting 5%–15% of patients [30]. In a retrospective study of 204 cases of breast lymphoma, it was found that the age at diagnosis ranges from 50 to 60 years, with a median age at diagnosis of 71 years [31].…”

“…Breast lymphoma may occur as either primary or secondary breast involvement [32, 33]. The definition of primary breast lymphoma (PBL) comprises only stage I (lymphoma limited to the breast) and stage II tumors (lymphoma confined to the breast and axillary lymph nodes), whereas in secondary breast lymphoma (SBL), the breast is involved, but through the secondary infiltration of a systematic disease [30, 33]. Distinguishing between PBL and SBL is vital since differences exist in tumor biology and aggressiveness [34].…”

“…According to some authors, breast lymphoma commonly occurs as a breast mass given its fast growth [32, 36]. However, the clinical data expose how changes in the subcutaneous tissue or the skin, or ipsilateral lymph node enlargement, may be present ( Case 9 , Figures 9(a), 9(b), 9(i), and 9(j) ) [30, 35]. A further observational point in the literature is the right breast affectation in both PBL and SBL [30].…”

Primary Bilateral Malignant Non-Hodgkin’s Lymphoma of the Breast: A Case Report and Review of the Literature

“…Primary non-Hodgkin's lymphoma of the breast (PNHL) is a rare entity, accounting for approximately 0.04% to 0.5% of all malignant breast tumors and forming approximately 1.7% to 2.2% of Extra-ganglionic NHL [1] [2] [3]. Their heterogeneity is reflected by various clinical, morphological, immunological and cytogenetic presentations which explain their different classifications.…”