Breast masses in adolescent females

Diehl, T.; Kaplan, Deborah Abrams

doi:10.1016/s0197-0070(85)80002-4

Cited by 19 publications

(5 citation statements)

References 16 publications

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“…Multiple fibroadenomas occur in 10 to 25% of cases. 3,4 In adolescents, the mass regresses completely between 10 and 40% of the time. 1,5 Fibroadenomas are a stromal and epithelial proliferation arising from the terminal duct-lobular unit, though there are several histological variants.…”

Section: Presentationmentioning

confidence: 99%

Diagnosis and Management of Fibroadenomas in the Adolescent Breast

Cerrato

Labow

2013

Seminars in Plastic Surgery

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Fibroadenomas are benign breast masses that can present a management challenge in adolescent populations. Most fibroadenomas may be managed conservatively without surgery, but those masses that are symptomatic or increasing in size may require surgical excision. In adolescents, the implications of surgical intervention in the breast are unclear, and there is little outcomes data. In this article, the authors discuss the presentation, diagnosis, and management of fibroadenoma in adolescents. Key considerations for physicians in treating these masses in this population are reviewed.

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Section: Presentationmentioning

confidence: 99%

Diagnosis and Management of Fibroadenomas in the Adolescent Breast

Cerrato

Labow

2013

Seminars in Plastic Surgery

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“…In a recent publication, McLaughlin et al [6] developed a clinical algorithm focusing on the safety of clinical observation. This algorithm, along with other studies, suggests that a reasonable observation period for patients with clinically benign breast disease is within the range of one to four menstrual cycles (or months) [1,5,15,16]. Just over half of our patient cohort (54.3%) completed an observation interval of at least 90 days with the remainder undergoing an intervention within a month (average intervention time of 11 days).…”

Section: Discussionmentioning

confidence: 73%

Pathologic discordance to clinical management decisions suggests overtreatment in pediatric benign breast disease

Westfal

Perez

Hung

et al. 2019

Breast Cancer Res Treat

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Purpose: Breast masses in pediatric patients are often managed in a similarly to adult breast masses despite significant differences in pathology and natural history. Emerging evidence suggests that clinical observation is safe. The purpose of this study was to quantify the clinical appropriateness of the management of benign breast disease in pediatric patients.Methods: A multi-institutional retrospective cohort study was completed between 1995-2017. Patients were included if they had benign breast disease and were 19 years old or younger. A timeline of all interventions (ultrasound, biopsy, or excision) was generated to quantify the number of patients who were observed for at least 90 days, deemed appropriate care. To quantify inappropriate care, the number of interventions performed within 90 days, and the pathologic concordance to clinical decisions was determined by reviewing the radiology reports of all ultrasounds and pathology reports of all biopsies and excisions.Results: A total of 1,909 patients were analyzed. Mean age was 16.4 years old (± 2.1). The majority of masses were fibroadenomas (60.4%). Only half of patients (54.3%) were observed for 90 or more days. 81.1% of interventions were unnecessary, with pathology revealing masses that would be safe to observe. The positive predictive value (PPV) of clinical decisions made based on suspicious ultrasound findings was 16.2%, not different than a PPV of 21.9% (p<0.25) for decisions made on clinical suspicion alone.Terms of use and reuse: academic research for non-commercial purposes, see here for full terms. https://www.springer.com/aamterms-v1

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“…It has been reported in various series that the most common pediatric breast mass is fibroadenoma (54% -94%) (8)(9)(10)(11). Because these masses are estrogen sensitive, they are not usually seen before puberty (12).…”

Section: Discussionmentioning

confidence: 99%

“…The frequency of sonographic follow-up is shorter, and the referral size of surgical resection is larger than adults. It is stated that a 20% increase in size in six months during the follow-up period cannot be accepted as in adults (10). It is argued that doubling of the lesion size in children should be an indication for biopsy.…”

Section: Discussionmentioning

confidence: 99%

Biopsied breast masses in adolescents. Analysis of clinical features

Atay

Sezgin²,

Gür³

2022

Med Sci Discov

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Objective: Breast lesions in childhood are mostly benign and self-limiting, and the biopsy indications are restricted in this period. The differentiation between fibroadenomas and phyllodes tumors is difficult with imaging because of their overlap in initial size and growth rate. Therefore, biopsy or excision may be required. Material and Methods: We retrospectively reviewed data from 531 patients (404 females, 76.1%; 127 males, 23.9%) that were applied to our center between 2009 and 2019. Breast US was performed to all applicants with pain and swelling in the their breast. Patients with fibroadenoma with and without core biopsy were recorded. Results: Thirty-one solid breast lesions were detected. Twenty-one lesions were performed biopsy (21/531, 3.9 %). The most common mass lesion was fibroadenoma (27/31, 87.1%) and the most frequently biopsied lesion was fibroadenoma (11/21; 52.3%). The 10 simple fibroadenomas, one juvenil fibroadenoma, one benign phyllodes tumors, and two invasive ductal carcinomas have been identified. A statistically significant difference (p< 0.05) was detected between the groups with or without core biopsy for the size of fibroadenomas, but there was no statistically significant difference between both groups for patients’ age with fibroadenoma. Conclusion: Malignancies in the breast and lesions such as fibroadenoma that requires a malignancy exclusion are observed in children and adolescents. Large size is a statistically significant parameter in the biopsy decision.

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Breast masses in adolescent females

Cited by 19 publications

References 16 publications

Diagnosis and Management of Fibroadenomas in the Adolescent Breast

Diagnosis and Management of Fibroadenomas in the Adolescent Breast

Pathologic discordance to clinical management decisions suggests overtreatment in pediatric benign breast disease

Biopsied breast masses in adolescents. Analysis of clinical features

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