Breast Masses with Peripheral Rim Enhancement on Dynamic Contrast-enhanced MR Images: Correlation of MR Findings with Histologic Features and Expression of Growth Factors

Abstract

Rim enhancement of breast lesions at MR imaging is due to a combination of angiogenesis, distribution and degree of fibrosis, expression pattern of VEGF, and various histologic features.

Contrast-Enhancement of the Anterior Eye Segment in Patients with Retinoblastoma: Correlation between Clinical, MR Imaging, and Histopathologic Findings

“…Regulatory proteins other than VEGF, which show mutually opposing functions of stimulating angiogenesis and inhibiting inflammation, might play an additional role. 30,31 Furthermore, the AES is not always involved in posterior uveitis; therefore, differences in the extent and severity of uveal contrast enhancement depend on the severity of BOB breakdown in the AES. 32 Limitations to this study are primarily related to the retrospective design.…”

Dynamic High-Spatial-Resolution MR Imaging of Invasive Ductal Carcinoma: Influence of Histological Scirrhous Component on MR Descriptors

“…[1][2][3][4][5][6][7][8] Several morphologic characteristics and kinetic patterns on MR imaging in breast carcinoma are explained primarily by the histological structures and the degree of tumor angiogenesis. [9][10][11][12][13][14][15] In addition, tumor vascularity detected on imaging may be in‰uenced by the histological growth pattern of the carcinoma, such as scirrhous or solidtype carcinoma. 16 In our study, mass margin (Pº0.001) and kinetic pattern (P＝0.04) were signiˆcantly diŠerent among the 3 SCD groups.…”

“…4,5,[21][22][23] Buadu and associates 9 reported diŠerent patterns of rim enhancement and concluded that early rim enhancement with progression to the center was fairly speciˆc for carcinomas. Matsubayashi's group 10 reported that whereas early Fig. 4.…”

“…[1][2][3][4][5][6][7][8] DiŠerences in the characteristics of MR enhancement between benign and malignant lesions are believed to re‰ect diŠerences in vascularity, vessel permeability, and extracellular diŠusion space. In addition, several morphologic characteristics and kinetic patterns on MR imaging in breast carcinoma are primarily explained by the histological structures of the lesions, [9][10][11] such as centralˆbrosis, central necrosis, marginalˆbrosis, and the degree of tumor angiogenesis. 9,10,[12][13][14][15] However, we previously reported that the tumor vascularity of breast carcinoma on power Doppler ultrasonography depended not only on the degree of tumor angiogenesis, but also on the growth pattern (solid versus``scirrhous'' type).…”

“…In addition, several morphologic characteristics and kinetic patterns on MR imaging in breast carcinoma are primarily explained by the histological structures of the lesions, [9][10][11] such as centralˆbrosis, central necrosis, marginalˆbrosis, and the degree of tumor angiogenesis. 9,10,[12][13][14][15] However, we previously reported that the tumor vascularity of breast carcinoma on power Doppler ultrasonography depended not only on the degree of tumor angiogenesis, but also on the growth pattern (solid versus``scirrhous'' type). 16 The purpose of our present study was to assess the relationship between the amount of scirrhous component in invasive ductal carcinoma and the morphologic and kinetic patterns on MR imaging.…”