Breast Metastasis from Neuroendocrine Carcinoma of the Lung: A Case Report and Review of the Literature

Abstract

Breast metastasis originating from non-mammary tumors is an uncommon event accounting for 0.5–6.6% of all breast neoplasms. The primary malignancies that reportedly metastasize to the breast most frequently are hematologic malignancies, such as leukemia and lymphoma and malignant melanoma. Breast cancer metastasis resulting from a primary lung neoplasm is significantly less commonly described in the literature. Herein, we present the unusual case of a patient with metastatic disease to the breast from a primary lung tumor.

Bilateral Metastatic Gynecomastia from Small-Cell Lung Tumors in a Man: A Report of a Rare Case

“…SLCS is an aggressive neuroendocrine tumor that exceptionally metastasizes to the breast (0.2%-1.3%) [1,5]. Pulmonary SLCS is often diagnosed incidentally, given its insidious nature [2,6]. There are only two cases of bilateral breast metastases from pulmonary SLCS in male patients reported in the literature in 1976 and 2011 [7,3].…”

Unusual presentation of a small cell lung cancer with bilateral breast metastases: Case report and a brief review of the literature

“…Approximately 70% of the patients with SCLC already have metastasis at diagnosis. Despite being a common and aggressive tumor with a tendency to metastasize, breast involvement is surprisingly rare [ [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] ]. The prognosis is abysmal whether one or both breasts are involved by SCLC, with an estimated five-year survival of only 2% [ 13 ].…”