Breast metastasis from ovarian cancer: A case report

Abstract

Breast metastasis from ovarian cancer is a rare event, with vary clinical and imaging presentations, depends on the form of dissemination of the disease and may mimic primary benign and malignant lesions.Confirmation of the diagnosis is of pivotal importance to choice an adequate therapeutic planning, allowing to avoid unnecessary surgeries and to provide appropriate systemic therapy. In this manuscript, we present a case of breast metastasis from ovarian cancer. The patient presented to our Institute with a localized, palpable mass in the upper outer quadrant of the right breast. Mammography and breast sonography showed a singular, round, and homogenous mass with regular borders. No suspicious axillary node was observed. Lesion biopsy revealed the presence of epithelial malignant tumor cells, compatible with a tube-ovarian serous histotype. So, although it could be rare, secondary malignant neoplasm should be considered in the differential diagnosis of breast lesions in patients with a personal history of ovarian cancer.

Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature

“…Serous papillary carcinoma is the most common histotype of ovarian tumor associated with breast metastases [10], as it has been reported in 72% of the cases and it is usually detected within 2 years from the initial diagnosis of primary ovarian cancer [3], as in our case. Metastatic disease to the breast is more likely to present with an axillary mass, thus suggesting a lymphatic route of EOC spreading.…”

Breast and Axillary Lymph Node Metastasis from Ovarian Cancer: A Case Report

“…BOM is usually associated with the serous papillary adenocarcinoma subtype, an aggressive and advanced disease, and a poor prognosis [ 9 – 19 ].As BMs usually develop out of the mammary ductal system, they clinically present as round, rapid growing, painless, and mobile lesions without any cutaneous alteration [ 4 – 8 ].Radiologically, BMs typically appear as regular lesions without skin infiltration or peri-tumoral desmoplastic reaction [ 4 – 8 ]. Microcalcifications are rare and usually associated with psammoma bodies in ovarian cancer patients [ 4 – 9 ]. On ultrasonography, BMs have a regular shape and a hypoechogenic aspect with indistinct margins and a posterior enhancement, in the absence of any spiculations, calcifications, or architectural distortion [ 4 – 8 ].…”

BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography

“…The breast is a relatively uncommon site of metastatic spread. Only 0.3–6.3% of malignant breast tumors originate from a solid tumor somewhere other than the breast ( Antuono et al, 2018 ). Ovarian cancer metastasizes to the breast very rarely, in only 0.03–0.6% of cases ( El Attrache et al, 2017 ).…”