Breast Physiology

Sun, Susie X.; Bostanci, Zeynep; Kass, Rena; Mancino, Anne T.; Rosenbloom, Arlan L.; Klimberg, V. Suzanne; Bland, Kirby I.

doi:10.1016/b978-0-323-35955-9.00003-9

Cited by 17 publications

(4 citation statements)

References 209 publications

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“…Existing research suggests that the manner in which familial history influences the risk of fibroadenoma may be mediated by genetic variants, shared environmental factors, or a combination of the two. The hormonal regulation and response of breast tissue to hormonal changes during puberty, pregnancy, and other periods of hormonal fluctuation may be influenced by these genetic factors [30] .…”

Section: Discussionmentioning

confidence: 99%

Risk factors for fibroadenoma mammae (FAM) among adult women at the South Tangerang General Hospital in Indonesia

Jaksa,

Fachri,

Andriyani

et al. 2024

Trends Immunother.

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A frequent benign breast tumor, fibroadenoma mammae (FAM), has extra stromal and epithelial components in the breast tissue. Despite not being fatal, FAM increases breast cancer risk, highlighting the necessity to recognize it. Estrogen and progesterone levels during menstruation, pregnancy, and lactation may alter FAM development. Therefore, this study examines FAM risk variables in adult women at South Tangerang Regional General Hospital, Indonesia. Adult women in General Hospital of South Tangerang City, Indonesia were studied using a case-control design with 85 cases and 85 controls. South Tangerang General Hospital recruited volunteers between December 2023 and January 2024 using purposeful sampling. FAM patients with a history of therapy were cases, while Eye Clinic patients without FAM were controls. Viral diseases, major cardiovascular problems in the past three years, and unstable weight were excluded. Multivariate analyses employed multiple logistic regression, while univariate and bivariate analyses used percentages and chi-square test. Fibroadenoma mammae (FAM) prevalence in adult women at South Tangerang General Hospital is highly correlated with age, age of menarche, family history, hormonal contraceptive use, and nutritional status. Abnormal nutrition was the largest risk factor for FAM in hospitalized adult women (aOR = 8.678, p < 0.000). The study stresses the link between nutritional state and FAM, with abnormal nutritional status increasing risk. This shows how diet and nutrition affect FAM sensitivity. To reduce FAM prevalence, demographic, genetic, hormonal, and lifestyle factors must be understood and addressed due to their complex interaction. Dietary strategies that promote healthy eating may reduce FAM risk.

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Section: Discussionmentioning

confidence: 99%

Risk factors for fibroadenoma mammae (FAM) among adult women at the South Tangerang General Hospital in Indonesia

Jaksa,

Fachri,

Andriyani

et al. 2024

Trends Immunother.

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“…Sixty-seven per cent of accessory breast tissue are present in the thoracic and abdominal part of the milk line, with another 20% occurring in axilla 1. Embryologically, the failure of normal apoptotic regression of mammary ridges during gestation leads to the formation of supernumerary breast tissue 2. These accessory breasts can undergo physiological changes similar to normal breast tissue, such as cyclical pain during menstruation, swelling and lactation.…”

Section: Discussionmentioning

confidence: 99%

Fibroadenoma in axillary ectopic breast

et al. 2022

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Axillary lumps are common clinical presentations in surgery, which have various differential diagnoses. We encountered an unusual case of an isolated axillary mass. The patient was a young woman in her 20s with a 2 year history of right axillary swelling. Clinically, the lump measured 3 cm ×3 cm, mobile, non-tender, and there was no associated breast lump or skin changes. Our initial impression was an isolated lymphadenopathy, and further workup for tuberculosis lymphadenopathy returned negative. Ultrasound demonstrated a well circumscribed oval lesion, and fine needle aspiration could only identify a benign proliferative breast tissue. As it was increasing in size and causing discomfort, we decided for an excision biopsy for both diagnostic and therapeutic reasons. Intraoperatively, the lump was noted to have well defined, smooth surface along with whitish-grey appearance. The tissue surrounding it was also removed and sent for histopathological assessment. Results confirmed our diagnosis of fibroadenoma in an ectopic breast tissue.

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“…walking on a treadmill, running, or ascending and descending on an elevation. The female breast is essentially composed of four structures: lobules or glands, milk ducts, fat and connective tissue and each has different mechanical properties [12]. For this reason, when creating FE (Finite Element) models, certain simpli cations are adopted.…”

Section: State Of the Artmentioning

confidence: 99%

Numerical and Physical Modelling of Breast Cancer Based on Image Fusion and Artificial Intelligence

Dołęga-Kozierowski

Kasprzak

Lis

et al. 2023

Preprint

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Purpose The key problem raised in the paper is the change in the position of the breast tumor due to magnetic resonance imaging examinations in the abdominal position relative to the supine position during the surgical procedure. Changing the position of the patient leads to significant deformation of the breast, which leads to the inability to indicate the location of the neoplastic lesion correctly.Methods This study outlines a methodological process for treating cancer patients. Pre-qualification assessments are conducted for magnetic resonance imaging (MRI), and 3D scans are taken in three positions: supine with arms raised (SU), supine surgical position (SS), and standing (S). MRI and standard ultrasonography (USG) imaging are performed, and breast and cancer tissue are segmented from the MRI images. Finite element analysis is used to simulate tissue behavior in different positions, and an artificial neural network is trained to predict tumor dislocation. Based on the model, a 3D-printed breast with a highlighted tumor is manufactured. This computer-aided analysis is used to create a detailed surgical plan, and lumpectomy surgery is performed in the supine surgical position (SS). In addition, the geometry of the tumor is presented to the medical staff as a 3D-printed element.Results By utilizing a comprehensive range of techniques, including pre-qualification assessment, 3D scanning, MRI and USG imaging, segmentation of breast and cancer tissue, model analysis, image fusion, finite element analysis, artificial neural network training, and additive manufacturing, a detailed surgical plan can be created for performing lumpectomy surgery in the supine surgical position.Conclusion The new approach developed for the pre-operative assessment and surgical planning of breast cancer patients has demonstrated significant potential for improving the accuracy and efficacy of surgical procedures. This procedure may also help the pathomorphological justification. Moreover, transparent 3D-printed breast models can benefit breast cancer operation assistance. The physical and computational models can help surgeons visualize the breast and the tumor more accurately and detailedly, allowing them to plan the surgery with greater precision and accuracy.

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Breast Physiology

Cited by 17 publications

References 209 publications

Risk factors for fibroadenoma mammae (FAM) among adult women at the South Tangerang General Hospital in Indonesia

Risk factors for fibroadenoma mammae (FAM) among adult women at the South Tangerang General Hospital in Indonesia

Fibroadenoma in axillary ectopic breast

Numerical and Physical Modelling of Breast Cancer Based on Image Fusion and Artificial Intelligence

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