Breast Reconstruction Using a Three-Dimensional Absorbable Mesh Scaffold and Autologous Fat Grafting: A Composite Strategy Based on Tissue-Engineering Principles

Hwang, Kun; Wu, Xiajing

doi:10.1097/prs.0000000000008381

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Conscious design and additive manufacturing are critical to engineering reliable and reproducible scaffolds to protect tissue regeneration. It overcomes the repeatability issues reported in [ 20 ] when using an alternative method of folding surgical mesh to create a scaffold [ 19 ]. An additional benefit of additive manufacturing is the ability to design scaffolds which are patient-matched.…”

Section: Discussionmentioning

confidence: 99%

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Conceptualizing Scaffold Guided Breast Tissue Regeneration in a Preclinical Large Animal Model

Cheng,

Janzekovic,

Finze

et al. 2024

Bioengineering

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Scaffold-guided breast tissue regeneration (SGBTR) can transform both reconstructive and cosmetic breast surgery. Implant-based surgery is the most common method. However, there are inherent limitations, as it involves replacement of tissue rather than regeneration. Regenerating autologous soft tissue has the potential to provide a more like-for-like reconstruction with minimal morbidity. Our SGBTR approach regenerates soft tissue by implanting additively manufactured bioresorbable scaffolds filled with autologous fat graft. A pre-clinical large animal study was conducted by implanting 100 mL breast scaffolds (n = 55) made from medical-grade polycaprolactone into 11 minipigs for 12 months. Various treatment groups were investigated where immediate or delayed autologous fat graft, as well as platelet rich plasma, were added to the scaffolds. Computed tomography and magnetic resonance imaging were performed on explanted scaffolds to determine the volume and distribution of the regenerated tissue. Histological analysis was performed to confirm the tissue type. At 12 months, we were able to regenerate and sustain a mean soft tissue volume of 60.9 ± 4.5 mL (95% CI) across all treatment groups. There was no evidence of capsule formation. There were no immediate or long-term post-operative complications. In conclusion, we were able to regenerate clinically relevant soft tissue volumes utilizing SGBTR in a pre-clinical large animal model.

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Section: Discussionmentioning

confidence: 99%

“…However, the long-term outcomes are not reported, and there has been variable success. Another approach has used folded surgical mesh [ 19 ] at the time of implantation; however, this technique has not been successfully reproduced by others, likely due to is complexity [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Conceptualizing Scaffold Guided Breast Tissue Regeneration in a Preclinical Large Animal Model

Cheng,

Janzekovic,

Finze

et al. 2024

Bioengineering

View full text Add to dashboard Cite

show abstract

“…Conscious design and additive manufacturing is critical to engineer a reliable and reproducible scaffold to protect tissue regeneration. It overcomes repeatability issues reported [20] when using an alternative method of folding surgical mesh to create a scaffold [19].…”

Section: Groupsmentioning

confidence: 99%

Conceptualizing Scaffold Guided Breast Tissue Regeneration in a Preclinical Large Animal Model

Cheng,

Janzekovic,

Finze

et al. 2024

Preprint

View full text Add to dashboard Cite

Scaffold guided breast tissue regeneration (SGBTR) can both transform reconstructive and cosmetic breast surgery. Implant-based surgery is the most common method. However, there are inherent limitations as there is replacement of tissue rather than regeneration. Regenerating autologous soft tissue has the potential to provide a more like-for-like reconstruction with minimal morbidity. Our SGBTR approach regenerates soft tissue by implanting additively manufactured bioresorbable scaffolds filled with autologous fat graft. A pre-clinical large animal study was conducted implanting 100 ml breast scaffolds (n=55) made from medical-grade polycaprolactone in 11 minipigs for 12 months. Various treatment groups were investigated where immediate or delayed autologous fat graft, as well as platelet rich plasma were added to scaffolds. Computed Tomography and Magnetic Resonance Imaging was performed on explanted scaffolds to determine volume and distribution of regenerated tissue. Histological analysis was performed to confirm tissue type. At 12 months we were able to regenerate and sustain a mean soft tissue volume of 60.9 4.5 ml (95% CI) across all treatment groups. There was no evidence of capsule formation. There were no immediate or long-term post-operative complications. In conclusion, we were able to regenerate clinically relevant soft tissue volumes utilizing SGBTR in a pre-clinical large animal model.

show abstract

“…14 No long-term outcome data were reported and the technique has not been successfully reproduced by others. 15 Scaffolds manufactured with 3D printing are consistent and permit tuning of parameters. This means that the scaffold can be customised to balance competing demands of mechanical support and porosity.…”

mentioning

confidence: 97%

Scaffold-guide breast tissue engineering: the future of breast implants

Cheng,

Heald,

Wagels

et al. 2023

Australas J Plast Surg

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Breast Reconstruction Using a Three-Dimensional Absorbable Mesh Scaffold and Autologous Fat Grafting: A Composite Strategy Based on Tissue-Engineering Principles

Cited by 3 publications

References 4 publications

Conceptualizing Scaffold Guided Breast Tissue Regeneration in a Preclinical Large Animal Model

Conceptualizing Scaffold Guided Breast Tissue Regeneration in a Preclinical Large Animal Model

Conceptualizing Scaffold Guided Breast Tissue Regeneration in a Preclinical Large Animal Model

Scaffold-guide breast tissue engineering: the future of breast implants

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