Breast tomosynthesis and digital mammography: a comparison of diagnostic accuracy

Svahn, Tony; Chakraborty, Dev P.; Ikeda, Debra M.; Zackrisson, Sophia; Do, Young-Rok; Mattsson, Sören; Andersson, Ingvar

doi:10.1259/bjr/53282892

Cited by 143 publications

(106 citation statements)

References 43 publications

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“…Typically, cancerous tumor has high density compared to surrounding region and can be easily distinguished from other regions. Studies [5][6][7] show that it gives a sensitivity of 68% to 88% (or as low as 48% for extremely dense breasts) and specificities ranging from 82% to 98%. In addition, it has the following disadvantages:…”

Section: Comparison With Mammographymentioning

confidence: 99%

Advances in Breast Thermography

Kakileti¹,

Manjunath²,

Madhu³

et al. 2017

New Perspectives in Breast Imaging

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Thermography-based breast cancer screening has several advantages as it is non-contact, non-invasive and safe. Many clinical trials have shown its effectiveness to detect cancer earlier than any other modality. Historically, thermography has only been used as an adjunct modality due to the high expertise required for manual interpretation of the thermal images and high false-positive rates otherwise found in general use. Recent developments in thermal sensors, image capture protocols and computer-aided software diagnostics are showing great promise in making this modality a mainstream cancer screening method. This chapter describes some of these advances in breast thermography and computeraided diagnostics that are poised to improve the quality of cancer care.

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Section: Comparison With Mammographymentioning

confidence: 99%

Advances in Breast Thermography

Kakileti¹,

Manjunath²,

Madhu³

et al. 2017

New Perspectives in Breast Imaging

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“…148,149 Studies have reported 7.2% -53% increase in cancer detection and 20% -59% reduction in recall rates with supplemental DBT. 31,44,45,150,151 Importantly, radiation dose to the dense tissue is lower for DBT than digital mammography (DM) for dense breasts; 43 therefore DBT is preferable to DM in terms of performance and dose, albeit it appears women with fatty breasts get higher dose on DBT. 152 Another approach suitable for imaging the dense breast is molecular breast imaging (MBI) or BreastSpecific Gamma Imaging (BSGI).…”

Section: Imaging the Dense Breastmentioning

confidence: 99%

Breast composition: Measurement and clinical use

Ekpo¹,

Hogg²,

Highnam³

et al. 2015

Radiography

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Breast density is a measure of the extent of radiodense fibroglandular tissue in the breast. The risk of developing breast cancer and the risk of missing cancer at screening rise with higher breast density. In this paper, the historical background to breast density measurement is outlined and current evidence based practice is explained. The relevance of breast density knowledge to mammographic practice and image interpretation is considered in the light of clinical assessment and notification of mammographic breast density (MBD). The current work also discusses risk stratification for decisionmaking regarding screening frequency and better modalities for earlier detection of breast cancer in the dense breast. Automated volumetric approaches are explained while ultrasound, digital breast tomosynthesis, molecular breast imaging, and magnetic resonance imaging are introduced as valuable adjuncts to digital mammography for imaging the dense breast. The work concludes on the important note that screened women should be notified of their breast density, and such notification should be accompanied with clear and adequate information about breast density and cancer risk, strategies associated with lower MBD, as well as best screening intervals and pathways for women with dense breasts. Adoption of these strategies may be crucial to early detection and treatment of cancer and improving survival from the disease.

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“…The readers had experience of DBT reading from previous studies [21][22][23]. Two blinded readers evaluated the DBT reading sequence independently from the two blinded readers of the DM reading sequence.…”

Section: Study Population and Image Readingmentioning

confidence: 99%

Factors affecting recall rate and false positive fraction in breast cancer screening with breast tomosynthesis – A statistical approach

et al. 2015

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Link to publication Citation for published version (APA): Rosso, A., Lång, K., Petersson, I., & Zackrisson, S. (2015). Factors affecting recall rate and false positive fraction in breast cancer screening with breast tomosynthesis -A statistical approach. Breast, 24(5), 680-686. DOI: 10.1016680-686. DOI: 10. /j.breast.2015 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractIn this study, we investigate which factors affect the false positive fraction (FPF) for digital breast tomosynthesis (DBT) compared to digital mammography (DM) in a screening population by using classification and regression trees (C&RT) and binary marginal generalized linear models.The data was obtained from the Malmö Breast Tomosynthesis Screening Trial, which aimed to compare the performance of DBT to DM in breast cancer screening. By using data from the first half of the study population (7 500 women), a tree with the recall probability for different groups was calculated. The effect of age and breast density on the FPF was estimated using a binary marginal generalized linear model.Our results show that breast density and breast cancer were the main factors influencing recall. The FPF is mainly affected by breast density and increases with breast density for DBT and DM.In conclusion, the results obtained with C&RT are easy to interpret and similar to those obtained using binary marginal generalized linear models. The FPF is approximately 40% higher for DBT compared to DM for all breast density categories.

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Breast tomosynthesis and digital mammography: a comparison of diagnostic accuracy

Abstract: The diagnostic accuracy of BT was superior to DM in an enriched population.

Cited by 143 publications

References 43 publications

Advances in Breast Thermography

Advances in Breast Thermography

Breast composition: Measurement and clinical use

Factors affecting recall rate and false positive fraction in breast cancer screening with breast tomosynthesis – A statistical approach

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