Breast Tumor Targetable Fe&lt;SUB&gt;3&lt;/SUB&gt;O&lt;SUB&gt;4&lt;/SUB&gt; Embedded Thermo-Responsive Nanoparticles for Radiofrequency Assisted Drug Delivery

Rejinold, N. Sanoj; Rg, Thomas; Muthiah, Muthunarayanan; Hj, Lee; Yy, Jeong; Park, In Kyu; Jayakumar, R.

doi:10.1166/jbn.2016.2135

Cited by 39 publications

(37 citation statements)

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“…After this pioneering work, the synthesis of the chitosan-graft-PVCL by the grafting onto approach has been documented by other authors [79][80][81][82][83][84][85]. The formation of amide bonds between PVCL-COOH and chitosan amino groups has been confirmed by FTIR [78,80,85], 1 H-NMR [78,85] and Raman [85] spectroscopy techniques.…”

Section: Synthesismentioning

confidence: 88%

“…In this report, 80 W for 2 min was required to heat the system up to 42 °C, and curcumin was controlled and released in cancer cells. These nanoparticles showed cellular internalization on array of the cancer cells, which decrease in cell viability and increase in cellular apoptosis [82].…”

Section: Applicationsmentioning

confidence: 99%

“…In this sense, beads and nanomaterials based on Cs-g-PVCL copolymer have been prepared by ionotropic gelation using sodium tripolyphosphate (TPP) as ionic cross-linking agent [78,[80][81][82][83][84]. Studies carried out by Prabaharan et al indicated that the copolymer has a swelling degree higher at pH 2.2 than at pH 7.4, decreasing with increased environmental temperature.…”

Section: Applicationsmentioning

confidence: 99%

“…Recently, several studies relative to Cs-g-PVCL nanoparticles loaded with curcumin (Cs-g-PVCL-CRC-NPs) have been investigated as a potential anticancer drug delivery carrier system [81][82][83][84]. These NPs exhibit similar morphology to those in Ref.…”

Section: Applicationsmentioning

confidence: 99%

“…In other articles, this group also describes Cs-g-PVCL-CRC-NPs in combination with metallic nanoparticles to assess their feasibility as a potential system for radio frequency (RF)-assisted cancer therapy [81][82][83]. With this purpose, gold nanoparticles (Au-NPs) were incorporated in Cs-g-PVCL-CRC-NPs in order to induce RF-assisted heating.…”

Section: Applicationsmentioning

confidence: 99%

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Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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Section: Synthesismentioning

confidence: 88%

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

See 3 more Smart Citations

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

View full text Add to dashboard Cite

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Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

Fernández‐Quiroz

Loya‐Duarte

Silva‐Campa

et al. 2019

J of Applied Polymer Sci

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This work describes the preparation of thermosensitive chitosan‐graft‐poly(N‐vinylcaprolactam) nanoparticles by ionic gelation and their potential use as a controlled drug delivery system, using doxorubicin as a model drug. A systematic study of the effect of the main processing parameters on both the size and thermoresponsive behavior of nanoparticles was investigated. The size of the particles is strongly dependent on the length of the poly(N‐vinylcaprolactam) grafted chains and the concentration of the copolymer and crosslinking agent solutions. The molecular structure of the copolymer plays an essential role in the phase transition temperature of the particles, which decreases with the length of PVCL grafted chain. The system displayed proper drug‐association parameters, and the drug‐loaded nanoparticles exhibited dose‐dependent cytotoxicity. A significant increase in the doxorubicin delivery rate was observed above the phase transition temperature (40 °C). These features indicate that these nanoparticles are suitable for the development of a new thermally controlled anti‐cancer drug delivery system. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47831.

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Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

Liao

Jia

et al. 2019

WIREs Nanomed Nanobiotechnol

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Cancer therapy is unsatisfactory as it typically has serious side effects, because normal cells in healthy organs are destroyed along with the tumor. Thus, researchers have tried to develop effective therapies with minimal side effects. One such method is to use nanotechnology to carry the drugs or therapeutic agents to the tumor region by secure encapsulation without leakage. Once the nanomedicine enters the target tumor site, it can release therapeutic agents in an effective manner. Accordingly, various nanomedicines have been developed to enhance the efficiency of cancer therapy and minimize the systematic toxicity. Here, we provide an overview and discuss the different types of responsive nanomedicines including physically, chemically, biologically, dual, and multi‐responsive nanomedicines, for the in situ release of cargos in recent years. We propose critical considerations that must be considered for the design of excellent stimuli‐nanomedicine. Furthermore, the possible directions for the development of successful stimuli‐responsive (smart) nanomedicine are highlighted. With the development of responsive nanomedicines, precise and personalized nanomedicine will be realized with great promise in the future. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Breast Tumor Targetable Fe<SUB>3</SUB>O<SUB>4</SUB> Embedded Thermo-Responsive Nanoparticles for Radiofrequency Assisted Drug Delivery

Cited by 39 publications

References 0 publications

Chitosan-Based Thermosensitive Materials

Chitosan-Based Thermosensitive Materials

Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

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