formance of our texture analysis using ranklet transform is less sensitive to the sonographic ultrasound platforms. Also, we adopt several co-occurrence statistics in terms of quantization levels and orientations (i.e., descriptor settings) for computing the co-occurrence matrices with 0.632+ bootstrap estimators to verify the use of the proposed texture analysis. These experiments suggest that the texture analysis using multi-resolution gray-scale invariant features via ranklet transform is useful for designing a robust CAD system.Index Terms-Breast sonography, computer-aided tumor diagnosis, gray-scale invariant features, multi-resolution approach, texture analysis, 0632+ bootstrap estimators.