Breastfeeding and migraine drugs

Davanzo, Riccardo; Bua, Jenny; Paloni, Giulia; Facchina, Giulia

doi:10.1007/s00228-014-1748-0

Cited by 42 publications

(39 citation statements)

References 89 publications

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“…Due to its very long elimination halflife in infants-19 days-use in breastfeeding women is discouraged. 105 Botulinum toxin type A No reports on the use of BTX-A during lactation are described in literature. Because of its high molecular weight, the drug is not expected to appear in the systemic circulation and would consequently not be excreted into breast milk.…”

Section: Ace Inhibitors Arbs and Calcium Channel Blockersmentioning

confidence: 98%

“…No adverse effects were reported in the breastfed infants. Although topiramate is generally regarded as compatible with breastfeedingdespite a less documented safety profile than comparable drugs 105 -it seems advisable to monitor at least the youngest infants for sedation, irritability, poor suckling, and diarrhoea, because of its relatively high RID values.…”

Section: Antiepilepticsmentioning

confidence: 99%

“…103 In a recent review, diclofenac and naproxen were also regarded as compatible with breastfeeding, but caution is warranted because the risk profile is less certain. 105 We suggest that naproxen and diclofenac should be regarded as second choices within the NSAID group.…”

Section: Paracetamolmentioning

confidence: 99%

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Pharmacological treatment of migraine during pregnancy and breastfeeding

et al. 2015

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Migraine affects up to 25% of women of reproductive age. In the majority of these women, migraine improves progressively during pregnancy, but symptoms generally recur shortly after delivery. As suboptimally treated migraine in pregnancy could have negative consequences for both mother and fetus, the primary aim of clinicians should be to provide optimal treatment according to stage of pregnancy, while minimising possible risks related to drug therapy. Nonpharmacological approaches are always first-line treatment, and should also be used to complement any required drug treatment. Paracetamol is the preferred drug for acute treatment throughout pregnancy. If paracetamol is not sufficiently effective, sporadic use of sumatriptan can be considered. NSAIDs such as ibuprofen can also be used under certain circumstances, though their intake in the first and third trimesters is associated with specific risks and contraindications. Preventive treatment should only be considered in the most severe cases. In women contemplating pregnancy, counselling is essential to promote a safe and healthy pregnancy and postpartum period for the mother and child, and should involve a dialogue addressing maternal concerns and expectations about drug treatment. This Review summarizes current evidence of the safety of the most common antimigraine medications during pregnancy and breastfeeding, and provides treatment recommendations for use in clinical practice.

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Section: Ace Inhibitors Arbs and Calcium Channel Blockersmentioning

confidence: 98%

Section: Antiepilepticsmentioning

confidence: 99%

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Pharmacological treatment of migraine during pregnancy and breastfeeding

et al. 2015

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“…The US Food and Drug Administration (FDA) published a safety announcement in 2015 addressing the concerns raised by these studies, and stated that all of the studies reviewed had potential limitations in their design and contained conflicting results. Current advice is that paracetamol remains safe for use during pregnancy and breastfeeding, and its use in any trimester does not appear to increase the risk of major birth defects . It is important to ensure that women are aware that many over‐the‐counter remedies for coughs and colds also contain paracetamol, and if taken alongside paracetamol can lead to inadvertent overdose.…”

Section: Antenatal Analgesiamentioning

confidence: 99%

Antenatal and Postnatal Analgesia

Bisson¹,

Newell²,

Laxton³

et al. 2018

BJOG

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“…Davanzo, Bua, Paloni, and Facchina () evaluated common medications prescribed for the management of migraines with regards to effects on breastfeeding, including nonsteroidal anti‐inflammatories drug (NSAIDs), triptans, beta‐blockers, calcium channel antagonists, anticonvulsants, antidepressants, and unclassified medications. Medications were classified based on pharmacokinetic parameters and RID levels as safe, moderately safe, or contraindicated for use during breastfeeding.…”

Section: Medications and Breastfeeding With Specific Chronic Illnessesmentioning

confidence: 99%