Breastfeeding and multiple sclerosis relapses: a meta-analysis

Pakpoor, Julia; Disanto, Giulio; Lacey, Melanie V.; Hellwig, Kerstin; Giovannoni, Gavin; Ramagopalan, Sreeram

doi:10.1007/s00415-012-6553-z

Cited by 82 publications

(57 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, a recent meta-analysis showed that women who breastfed were significantly less likely to use DMTs before conception, and had fewer relapses during pregnancy. 54 Overall, no clear evidence exists that breastfeeding provides sufficient protection from relapses to warrant not restarting DMTs shortly after giving birth, in women with active relapsing disease before pregnancy. Individual patients and their clinicians must weigh their decision to breastfeed on a case-by-case basis.…”

Section: Breastfeedingmentioning

confidence: 99%

Impact of sex hormones on immune function and multiple sclerosis development

2018

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting young people and leading to demyelination and neurodegeneration. The disease is clearly more common in women, in whom incidence has been rising. Gender differences include: earlier disease onset and more frequent relapses in women; and faster progression and worse outcomes in men. Hormone-related physiological conditions in women such as puberty, pregnancy, puerperium, and menopause also exert significant influence both on disease prevalence as well as on outcomes. Hormonal and/or genetic factors are therefore believed to be involved in regulating the course of disease. In this review, we discuss clinical evidence for the impact of sex hormones (estrogens, progesterone, prolactin, and testosterone) on MS and attempt to elucidate the hormonal and immunological mechanisms potentially underlying these changes. We also review current knowledge on the relationship between sex hormones and resident CNS cells and provide new insights in the context of MS. Understanding these molecular mechanisms may contribute to the development of new and safer treatments for both men and women.

show abstract

Section: Breastfeedingmentioning

confidence: 99%

Impact of sex hormones on immune function and multiple sclerosis development

2018

View full text Add to dashboard Cite

show abstract

“…45 However, the larger, pivotal PRIMS trial showed no benefit from breastfeeding. 47 A recent review tried to reconcile conflicting studies by suggesting that only exclusive breast-feeding (for at least 2 months) was protective. 46 Postpartum relapse rate was not affected by breast-feeding.…”

Section: Case 2-2mentioning

confidence: 99%

Multiple Sclerosis in Pregnancy

Coyle¹

2014

CONTINUUM: Lifelong Learning in Neurology

View full text Add to dashboard Cite

show abstract

“…A 2012 meta-analysis of 13 studies investigating the association between breastfeeding and MS relapse showed a tendency for fewer relapses in women who breastfed, suggesting that exclusive breastfeeding may reduce early postpartum relapses [8]. Indeed, breastfeeding should not be discouraged in favor of resuming MS medications.…”

Section: Post-partum Relapse Prevention and The Role Of Breastfeedingmentioning

confidence: 99%

Pregnancy in Multiple Sclerosis

Hellwig

2014

Eur Neurol

Self Cite

View full text Add to dashboard Cite

Background: The incidence of multiple sclerosis (MS) is increasing, particularly in young women (20−40 years). In line, experience in the management of pregnancies and use of disease-modifying therapy (DMT) in women with MS is accumulating. Summary: Fertility is generally not affected in MS. If assisted reproduction techniques (ART) are required, unsuccessful procedures are associated with an increased relapse risk, particularly in the first few months post-ART. During pregnancy, the risk of relapse declines continuously, especially in the third trimester, then increases early postpartum (3 months) and returns to pre-pregnancy levels at 4−6 months. The progression of MS disability is probably not influenced by pregnancy. Obstetrical outcomes show no increased risk for miscarriage/malformations, and the course of pregnancy is similar to that of women without MS, but with a tendency towards assisted delivery/cesarean section and reduced birth weights. Safety data regarding DMT in pregnancy and breastfeeding are limited. Exclusive breastfeeding may be beneficial and, hence, should not be discouraged in favour of resuming DMT except in cases of highly-active disease. Key Messages: The course of pregnancy in women with MS is broadly similar to that in women without MS; risk-to-benefit assessments are warranted when considering halting DMT before pregnancy and resuming DMT postpartum.

show abstract

Breastfeeding and multiple sclerosis relapses: a meta-analysis

Cited by 82 publications

References 11 publications

Impact of sex hormones on immune function and multiple sclerosis development

Impact of sex hormones on immune function and multiple sclerosis development

Multiple Sclerosis in Pregnancy

Pregnancy in Multiple Sclerosis

Contact Info

Product

Resources

About