Breastfeeding Associated with Reduced Mortality in Women with Breast Cancer

Lööf-Johanson, Margaretha; Brudin, Lars; Sundquist, M.; Rudebeck, Carl Edvard

doi:10.1089/bfm.2015.0094

Cited by 6 publications

(6 citation statements)

References 24 publications

(41 reference statements)

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“…In addition, breastfeeding has immediate and lasting benefits on maternal health, as demonstrated by several studies, which have shown a reduction in risk for some cancers, such as breast cancer, ovarian cancer, and endometrial cancer [4][5][6][7][8][9]. Benign breast disease does not usually interfere with a woman's ability to breastfeed [10,11].…”

Section: Introductionmentioning

confidence: 99%

Breastfeeding in Hospitals: Factors Influencing Maternal Choice in Italy

Ragusa¹,

Giorgianni

Marranzano

et al. 2020

IJERPH

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Monitoring the prevalence of breastfeeding is one of the actions provided for in Italian National Health System. This study aims to observe the prevalence of breastfeeding in a representative set of birthing hospitals in the province of Catania, in Sicily, Italy, to assess the factors influencing women in their decisions to breastfeed during hospitalization after delivery. We conducted an observational study on 3813 questionnaires administered to mothers of newborns during their hospital stay from the years 2016 to 2018 in eight hospitals of various types. The average maternal age was 31.3 years ± 5.8. Sixty-nine percent of women did not attend a prenatal course. From childbirth to discharge, the percentage of women who breastfed was 88%, of whom 45% did exclusive breastfeeding. Only 35% of women who had a caesarean section adopted exclusive breastfeeding. In our experience, rooming-in was not associated with an increase in breastfeeding. We observed that both attendance to prenatal courses and the mother’s education level played a minor role in influencing the mother’s decision in breastfeeding A fairly high percentage of exclusive breastfeeding, 75%, was attained just in one hospital, where dedicated staff was deployed to encourage breastfeeding. The lowest percentage (12%) of exclusive breastfeeding was observed in a large private accredited health facility. Hospital presence of professionals trained in human lactation is a smart investment for society.

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Section: Introductionmentioning

confidence: 99%

Breastfeeding in Hospitals: Factors Influencing Maternal Choice in Italy

Ragusa¹,

Giorgianni

Marranzano

et al. 2020

IJERPH

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“…The reproductive history of a woman is closely linked to breast cancer risk [8–10]. The first full-term pregnancy (FTP) is a key event in the determination of the fate of the mammary gland in a woman.…”

Section: Introductionmentioning

confidence: 99%

BC200 overexpression contributes to luminal and triple negative breast cancer pathogenesis

et al. 2019

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BackgroundLong non coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that are not translated into proteins, but regulate the transcription of genes involved in different cellular processes, including cancer. Epidemiological analyses have demonstrated that parous women have a decreased risk of developing breast cancer in postmenopausal years if they went through a full term pregnancy in their early twenties. We here provide evidence of the role of BC200 in breast cancer and, potentially, in pregnancy’s preventive effect in reducing the lifetime risk of developing breast cancer.MethodsTranscriptome analysis of normal breast of parous and nulliparous postmenopausal women revealed that several lncRNAs are differentially expressed in the parous breast. RNA sequencing of healthy postmenopausal breast tissue biopsies from eight parous and eight nulliparous women showed that there are 42 novel lncRNAs differentially expressed between these two groups. Screening of several of these 42 lncRNAs by RT-qPCR in different breast cancer cell lines, provided evidence that one in particular, lncEPCAM (more commonly known as BC200), was a strong candidate involved in cancer progression. Proliferation, migration, invasion and xerograph studies confirmed this hypothesis.ResultsThe poorly studied oncogenic BC200 was selected to be tested in vitro and in vivo to determine its relevance in breast cancer and also to provide us with an understanding of its role in the increased susceptibility of the nulliparous women to cancer. Our results show that BC200 is upregulated in nulliparous women, and breast cancer cells and tissue. The role of BC200 is not completely understood in any of the breast cancer subtypes. We here provide evidence that BC200 has a role in luminal breast cancer as well as in the triple negative breast cancer subtype.ConclusionWhen overexpressed in luminal and triple negative breast cancer cell lines, BC200 shows increased proliferation, migration, and invasion in vitro. In vivo, overexpression of BC200 increased tumor size. Although treatment for cancer using lncRNAs as targets is in its infancy, the advancement in knowledge and technology to study their relevance in disease could lead to the development of novel treatment and preventive strategies for breast cancer.

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“…The study also found no association between histological type and survival in common with other works. 49,50 Lööf-Johanson et al 51 reported that there was a higher survival rate for women with primary BC if overall breastfeeding was longer than 6 months and/or if they had at least one pregnancy. The results of our study were in line with other studies that reported different results.…”

Section: Resultsmentioning

confidence: 99%

Prognostic factors for cancer‐specific survival in 220 patients with breast cancer: A single center experience

et al. 2022

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Objectives Hospital‐based breast cancer survival studies are scarce in western Iran. Furthermore, the relationship between breast cancer survival and clinical parameters has been extensively studied, but many of the findings come from developing countries. This paper aims to estimate the survival of hospital‐based breast cancer patients and its predictor factors. Method This retrospective analysis was conducted on 578 patients with primary breast cancer who underwent surgery between 2004 and 2020. Information was collected from medical reports by the Hospital information system in Imam Reza Hospital, Kermanshah, Iran. One‐, 2‐, 5‐, and 10‐year breast cancer‐specific survival has been calculated using the Kaplan–Meier process. Crude and adjusted Hazard Ratios (HR) were calculated using the Cox proportional regression model. Result One‐, 2‐, and 5‐year overall breast cancer survival were 219 (99.54%), 196 (89.09%), 159 (72.27%), and 70 (31.81%), respectively. Univariate analysis of breast cancer patients with tumor‐related variables revealed that factors such as age, menopause status, lymph node metastasis, number of lymph nodes, organ metastasis, and stage of disease were significantly associated with disease‐specific survival ( p < .05). Multivariate analysis demonstrated that metastasis (HR = 41.77, 95% CI: 15.3–114.15) and lymph node metastasis (HR = 5.26, 95% CI: 1.9–14.6) were significantly related to survival. Conclusion The findings demonstrate that survival is relatively low and is consistent with late‐stage disease diagnosis. It is believed that this is due to a poor level of awareness, lack of screening programs, and subsequent late access to treatment.

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Breastfeeding Associated with Reduced Mortality in Women with Breast Cancer

Abstract: A total breastfeeding history >6 months and pregnancy are associated with both greater overall and breast cancer-specific survival for women diagnosed with breast cancer, having lived long enough for other causes of death to contribute substantially to mortality.

Cited by 6 publications

References 24 publications

Breastfeeding in Hospitals: Factors Influencing Maternal Choice in Italy

Breastfeeding in Hospitals: Factors Influencing Maternal Choice in Italy

BC200 overexpression contributes to luminal and triple negative breast cancer pathogenesis

Prognostic factors for cancer‐specific survival in 220 patients with breast cancer: A single center experience

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