Breath Analysis for Detecting Diseases on Respiratory, Metabolic and Digestive System

Abstract

Recently, biological technology and computer science are of great importance in medical applications. Since one's breath biomarkers have been proved to be related with diseases, it is possible to detect diseases by analysis of breath samples captured by e-noses. In this paper, a novel medical e-nose system specific to disease diagnosis was used to collect a large-scale breath dataset. Methods for signal processing, feature extracting as well as feature & sensor selection were discussed for detecting diseases on respiratory, metabolic and digestive system. Sequential forward selection is used to select the best combination of sensors and features. The experimental results showed that the proposed system was able to well distinguish healthy samples and samples with different diseases. The results also showed the most significant sensors and features for different tasks, which meets the relationship between diseases and breath biomarkers. By selecting best combination of different sensors and features for different tasks, the e-nose system is shown to be helpful and effective for diseases diagnosis on respiratory, metabolic and digestive system. Open Access https://doi.org/10.4236/jbise.2019.121004 40 J. Biomedical Science and Engineering Breath Analysis with E-NoseCurrently, the measurement of exhaled breath is usually performed by two common gas analysis apparatuses, gas chromatography (GC) [26] or electronic nose (e-nose) [27]. GC can separate and identify molecules that are responsible for typical odors occurring in specific diseases, which is very accurate for

A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease

“…Technology plays an active role in developing medical applications, while making use of information for making important decisions [ 1 ]. Breath sensor technology can be used as a tool for medical diagnostics [ 2 ].…”

“…The major compounds in exhaled breath are oxygen, CO 2 , water vapor, and nitrogen, with 500 different kinds of components. We can detect various diseases of the respiratory system, metabolic system and digestive system that significantly impact breath gases [ 1 ]. Breath gases are produced as a result of various metabolic processes that are released into blood.…”

“…Human breath analysis is a novel, easy, instant and non-invasive method to diagnose lung obstruction [ 1 ]. Some possible breath biomarkers for detection of obstructive lung diseases are nitric oxide (NO), hydrogen per oxide (H 2 O 2 ) , carbon monoxide (CO), hydrogen sulfide (H 2 S), alcohol (C 2 H 5 OH), acetone(C 2 H 6 CO) and ammonia (NH 3 ) [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”