Breath Analysis: Potential for Clinical Diagnosis and Exposure Assessment

Cao, Wenqing; Duan, Yixiang

doi:10.1373/clinchem.2005.063545

Cited by 364 publications

(251 citation statements)

References 115 publications

(113 reference statements)

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“…This is one reason to test the reactive paper spray method of analysing aldehydes with both benchtop and portable mass spectrometers. Breath analysis by mass spectrometry is an area of increasing interest due to its capability for making non-invasive measurements [35][36][37] which can be used to monitor metabolic state and potentially detecting disease biomarkers [38][39][40]. It is in this context that we describe a fast, direct and reactive paper spray approach to determine aldehydes using in-situ derivatization with 4-aminophenol to produce iminium ions.…”

Section: Introductionmentioning

confidence: 99%

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Bag

Hendricks

Reynolds

et al. 2015

Analytica Chimica Acta

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Ionization of aliphatic and aromatic aldehydes is improved by performing simultaneous chemical derivatization using 4-aminophenol to produce charged iminium ions during paper spray ionization.Accelerated reactions occur in the microdroplets generated during the paper spray ionization event for the tested aldehydes (formaldehyde, n-pentanaldehyde, n-nonanaldehyde, n-decanaldehyde, ndodecanaldehyde, benzaldehyde, m-anisaldehyde, and p-hydroxybenzaldehyde). Tandem mass spectrometric analysis of the iminium ions using collision-induced dissociation demonstrated that straight chain aldehydes give a characteristic fragment at m/z 122 (shown to correspond to protonated 4-(methyleneamino)phenol), while the arylaldehydeiminium ions fragment to give a characteristic product ion at m/z 120. These features allow straightforward identification of linear and aromatic aldehydes. Quantitative analysis of n-nonaldehyde using a benchtop mass spectrometer demonstrated a linear response over 3 orders of magnitude from 2.5 ng -5 µg of aldehyde loaded on the filter paper emitter. The limit of detection was determined to be 2.2 ng for this aldehyde. The method had a precision of 22%, relative standard deviation. The experiment was also implemented using a portable ion trap mass spectrometer.3

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Section: Introductionmentioning

confidence: 99%

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Bag

Hendricks

Reynolds

et al. 2015

Analytica Chimica Acta

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show abstract

“…The band at 942 cm -1 can be assigned to the stretching mode of W=O terminal bonds indicating surface tungsten hydrates [10,11]. Peaks at 203, 272, 303, 370, 425, 642, 688 and 805 cm -1 belong to the ε phase of WO 3 .…”

Section: As-sprayed Powdersmentioning

confidence: 99%

“…Nitric oxide belongs to the class of inorganic gaseous chemicals found in exhaled breath and is characterized as a signaling biomarker for disease [1][2][3]. The diagnostic value of exhaled NO measurements to differentiate between healthy persons with or without respiratory symptoms and patients with confirmed asthma has been established by Dupont who showed that >16 ppb of NO in lower respiratory tract could be treated as a cutoff for asthma with a 90% specificity and 90% positive predictive value [4].…”

Section: Introductionmentioning

confidence: 99%

Flame Spray Synthesis of WO3 for No Breath Monitors

Pi¹,

Wang²

2015

J Material Sci Eng

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“…For the sensor systems in this work, the Stern-Volmer [eqn (1)] and the two-site Demas model [eqn (2)] were employed to analyse the O 2 data.…”

Section: Sensor Response Behavior For O 2 Detectionmentioning

confidence: 99%

An integrated micro-volume fiber-optic sensor for oxygen determination in exhaled breath based on iridium(iii) complexes immobilized in fluorinated xerogels

Xiong

et al. 2013

Analyst

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A novel integrated fiber-optic sensor with micro detection volume is developed and evaluated for O 2 determination on a breath-by-breath basis in human health monitoring applications. The sensing element was fabricated by dip-coating an uncladded optical fiber with [Ir(piq) 2 (acac)]-doped hybrid fluorinated ORMOSIL (organically modified silicate) film, which was prepared from 3,3,3-trifluoropropyltrimethoxysilane (TFP-TriMOS) and n-propyltrimethoxysilane (n-propyl-TriMOS). The sensor was then constructed by inserting the prepared optical fiber into a transparent capillary. A microchannel formed between the optical fiber and the capillary inner wall acted as a flow cell for the sample flowing through. The evanescent wave (EW) field produced on the fiber core surface can excite the O 2 -sensitive fluorophores of [Ir(piq) 2 (acac)] to produce emission fluorescence. O 2 can be sensed by its quenching effect on the emission fluorescence intensity. Spectroscopic properties have been characterized by FTIR and fluorescence measurements. Stern-Volmer and Demas models were both employed to analyse the sensor sensitivity, which is 13.0 with the LOD ¼ 0.009% (3s) and the response time is about 1 s. By integrating the sensing and detection elements on the optical fiber, the novel configuration showed advantages of easy fabrication and low cost. Parameters of sensitivity, response time, repeatability, humidity effect and temperature effect were discussed in detail. The proposed sensor showed potential for practical in-breath O 2 analysis application due to its advantages of easy fabrication, low cost, fast response, excellent hydrophobicity, negligible temperature interference and suitable sensitivity.

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Breath Analysis: Potential for Clinical Diagnosis and Exposure Assessment

Cited by 364 publications

References 115 publications

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Flame Spray Synthesis of WO3 for No Breath Monitors

An integrated micro-volume fiber-optic sensor for oxygen determination in exhaled breath based on iridium(iii) complexes immobilized in fluorinated xerogels

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