Breath biopsy for early detection and precision medicine in cancer

Schee, Marc van der; Pinheiro, Hazel; Gaude, Edoardo

doi:10.3332/ecancer.2018.ed84

Cited by 23 publications

(16 citation statements)

References 27 publications

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“…Marc van der Schee, Head of Clinical, at Owlstone Medical, describes VOCs in the terms "a wealth of valuable information about the health of an individual. Over 1000 VOCs in breath have already been identified" [13].…”

Section: Introductionmentioning

confidence: 99%

Exhaled Breath Biopsy: A New Cancer Detection Paradigm

Abderrahman

2019

Future Oncol.

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Section: Introductionmentioning

confidence: 99%

Exhaled Breath Biopsy: A New Cancer Detection Paradigm

Abderrahman

2019

Future Oncol.

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“…There are studies using "breath biopsy" for the detection of cancer by differential ion mobility spectrometry but the device used in this study needs pre-analytic procedures with absorption/desorption tubes while using the STEP device the breath is aspirated during normal breathing and analyzed instantaneously [16]. This can also be performed by less trained staff and is well tolerated by the patients.…”

Section: Discussionmentioning

confidence: 99%

Rapid non-invasive detection of Influenza-A-infection by multicapillary column coupled ion mobility spectrometry

Steppert

Bollinger

et al. 2020

J. Breath Res.

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Infectious pathogens are a global issue. Global air travelling offers an easy and fast opportunity not only for people but also for infectious diseases to spread around the world within a few days. Also, large public events facilitate increasing infection numbers. Therefore, a rapid on-site screening for infected people is urgently needed.Due to the small size and easy handling, the ion mobility spectrometry coupled with a multicapillary column (MCC-IMS) is a very promising, sensitive method for the on-site identification of infectious pathogens based on scents, representing volatile organic compounds (VOCs).The purpose of this study was to prospectively assess whether identification of Influenza-Ainfection based on VOCs by MCC-IMS is possible in breath. Nasal breath was investigated in 24 consecutive persons with and without Influenza-A-infection by MCC-IMS. In 14 Influenza-A-infected patients, infection was proven by PCR of nasopharyngeal swabs. Four healthy staff members and six patients with negative PCR result served as controls. For picking up relevant VOCs in MCC-IMS spectra, software based on cluster analysis followed by multivariate statistical analysis was applied. With only four VOCs canonical discriminant analysis was able to distinguish Influenza-A-infected patients from not infected with 100% sensitivity and 100% specificity. This present proof-of-concept-study yields encouraging results showing a rapid diagnosis of viral infections in nasal breath within 5 minutes by MCC-IMS. The next step is to validate the results with a greater number of patients with Influenza-A-infection as well as other viral diseases, especially COVID-19. Registration number at ClinicalTrials.gov NCT04282135.

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“…Advances in precision medicine manifest into tangible benefits, such as early detection of disease 33 and designing personalized treatments are becoming more commonplace in health care. 34 The power of precision medicine to personalize care is enabled by several data collection and analytics technologies.…”

Section: Precision Medicinementioning

confidence: 99%

Precision Medicine, AI, and the Future of Personalized Health Care

Johnson

Wei

Weeraratne

et al. 2020

Clinical Translational Sci

738

227

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The convergence of artificial intelligence (AI) and precision medicine promises to revolutionize health care. Precision medicine methods identify phenotypes of patients with less‐common responses to treatment or unique healthcare needs. AI leverages sophisticated computation and inference to generate insights, enables the system to reason and learn, and empowers clinician decision making through augmented intelligence. Recent literature suggests that translational research exploring this convergence will help solve the most difficult challenges facing precision medicine, especially those in which nongenomic and genomic determinants, combined with information from patient symptoms, clinical history, and lifestyles, will facilitate personalized diagnosis and prognostication.

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Breath biopsy for early detection and precision medicine in cancer

Cited by 23 publications

References 27 publications

Exhaled Breath Biopsy: A New Cancer Detection Paradigm

Exhaled Breath Biopsy: A New Cancer Detection Paradigm

Rapid non-invasive detection of Influenza-A-infection by multicapillary column coupled ion mobility spectrometry

Precision Medicine, AI, and the Future of Personalized Health Care

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