Breath holding index and arterial stiffness in evaluation of stroke risk in diabetic patients

Zavoreo, Iris; Kes, Vanja Bašić; Ćorić, Lejla; Demarin, Vida

doi:10.1016/j.permed.2012.02.042

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…The BHI was decreasing with increasing arterial stiffness in diabetics, more so in patients with poor glycemic control. However, the exact correlation coefficient was not provided (Zavoreo et al 2012). In our study, we have shown that BHI was moderately correlated (r = −0.47) with PWV, therefore decreased CVR can be attributed to arterial stiffening only in part.…”

Section: Discussionmentioning

confidence: 66%

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Arterial Stiffening Contributes to Impairment of Cerebrovascular Reactivity in Patients With Coronary Artery Disease Without Carotid Stenosis

Ručka

Marek²,

Rucklova³

et al. 2015

Physiol Res

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Impaired cerebrovascular reactivity (CVR), an important risk factor for future stroke, is affected by a presence carotid stenosis. However, in some cases CVR can be impaired in the absence of carotid stenosis due to several poorly characterized mechanisms. We hypothesized that arterial stiffening as observed in coronary heart disease (CHD) could be associated with alteration in CVR in CHD patients without carotid stenosis. The study population consisted of patients referred for coronary angiography without significant carotid stenosis (<50 %). CVR was evaluated by breath holding index (BHI) measured with transcranial color code duplex ultrasound. Arterial stiffness was assessed by pulse wave velocity (PWV) measured by the oscillometric method. The extent of coronary atherosclerosis was quantified by Gensini score (GS). Out of 186 subjects, sixty-two patients fulfilled the inclusion and exclusion criteria. BHI decreased with increasing PWV (r = –0.47, p<0.001). Decrease in BHI was significantly inversely associated with GS (r = –0.61, p<0.001). GS was associated with PWV (p<0.001). In conclusion, impaired CVR was associated with increased arterial stiffening in CHD patients in the absence of significant carotid stenosis. Thus, we speculate that increased arterial stiffness may at least partially contribute to the pathophysiology of CVR alteration in coronary artery disease.

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Section: Discussionmentioning

confidence: 66%

“…It has been recently shown that increased arterial stiffness may be associated with decreasing BHI in healthy population (Zavoreo and Demarin 2010) and in diabetic patients (Zavoreo et al 2012). It seems plausible that increased arterial stiffening may limit vasodilatation and thus may participate on impaired CVR.…”

Section: Introductionmentioning

confidence: 96%

Arterial Stiffening Contributes to Impairment of Cerebrovascular Reactivity in Patients With Coronary Artery Disease Without Carotid Stenosis

Ručka

Marek²,

Rucklova³

et al. 2015

Physiol Res

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“…10,100,101 The BHI values reported here are within the range of what is expected in a healthy young cohort but is higher than has been reported in some healthy cohorts. [102][103][104][105] The difference may be explained by the fact that some groups identify the maximum CBF at the moment the breath-hold ends, 41,106 which underestimates the BHI because the maximum CBF is expected to occur a few seconds after the completion of the breathhold. 100,106,107 Another consideration is the focus on a single breath-hold, rather than averaging multiple breath-holds as is performed by some groups.…”

Section: Discussionmentioning

confidence: 99%

Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver

Favilla,

Carter,

Hartl

et al. 2024

Neurophoton.

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Bedside cerebral blood flow (CBF) monitoring has the potential to inform and improve care for acute neurologic diseases, but technical challenges limit the use of existing techniques in clinical practice.Aim: Here, we validate the Openwater optical system, a novel wearable headset that uses laser speckle contrast to monitor microvascular hemodynamics.Approach: We monitored 25 healthy adults with the Openwater system and concurrent transcranial Doppler (TCD) while performing a breath-hold maneuver to increase CBF. Relative blood flow (rBF) was derived from changes in speckle contrast, and relative blood volume (rBV) was derived from changes in speckle average intensity.Results: A strong correlation was observed between beat-to-beat optical rBF and TCD-measured cerebral blood flow velocity (CBFv), R ¼ 0.79; the slope of the linear fit indicates good agreement, 0.87 (95% CI: 0.83 −0.92). Beat-to-beat rBV and CBFv were also strongly correlated, R ¼ 0.72, but as expected the two variables were not proportional; changes in rBV were smaller than CBFv changes, with linear fit slope of 0.18 (95% CI: 0.17 to 0.19). Further, strong agreement was found between rBF and CBFv waveform morphology and related metrics.Conclusions: This first in vivo validation of the Openwater optical system highlights its potential as a cerebral hemodynamic monitor, but additional validation is needed in disease states.

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“…[115][116][117][118][119][120][121][122][123][124][125][126] Brain plasticity opposes the idea that brain functions are fixed at a particular time 117,127 ; instead, it refers to the ability of the human brain to change as a result of one's experience that the human brain is "plastic" and "flexible". 128 Musical training, improvisation, and exercises are among the most effective inducers of brain plasticity and lead to improved EFs (in the short and long term, based on durations and intensities). In musical improvisation, fMRI studies have shown motor and auditory cortex reorganization in professional musicians; other studies revealed changes in neurotransmitter and hormone serum levels in correlation to music (for an overview, see 2,129 ).…”

Section: B R Ain Pl a S Ti Cit Y And Cre Ativit Ymentioning

confidence: 99%

Creative therapy in health and disease: Inner vision

Khalil

Demarin

2023

CNS Neurosci Ther

Self Cite

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Can we better understand the unique mechanisms of de novo abilities in light of our current knowledge of the psychological and neuroscientific literature on creativity? This review outlines the state‐of‐the‐art in the neuroscience of creativity and points out crucial aspects that still demand further exploration, such as brain plasticity. The progressive development of current neuroscience research on creativity presents a multitude of prospects and potentials for furnishing efficacious therapy in the context of health and illness. Therefore, we discuss directions for future studies, identifying a focus on pinpointing the neglected beneficial practices for creative therapy. We emphasize the neglected neuroscience perspective of creativity on health and disease and how creative therapy could offer limitless possibilities to improve our well‐being and give hope to patients with neurodegenerative diseases to compensate for their brain injuries and cognitive impairments by expressing their hidden creativity.

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Breath holding index and arterial stiffness in evaluation of stroke risk in diabetic patients

Cited by 5 publications

References 20 publications

Arterial Stiffening Contributes to Impairment of Cerebrovascular Reactivity in Patients With Coronary Artery Disease Without Carotid Stenosis

Arterial Stiffening Contributes to Impairment of Cerebrovascular Reactivity in Patients With Coronary Artery Disease Without Carotid Stenosis

Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver

Creative therapy in health and disease: Inner vision

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