Breath Test or Duodenal Aspirate for Small Intestinal Bacterial Overgrowth: Still No Breath of Fresh Air

Shah, Eric D.

doi:10.1007/s10620-020-06556-0

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…A complicating feature for the diagnosis is that these risk factors often appear in other diseases, making SIBO intertwined with other pathologies among which gastroenterological disorders (e.g. inflammatory bowel disease, irritable bowel syndrome, SBS, nonalcoholic fatty liver disease, cirrhosis, diabetes, and cystic fibrosis (Ierardi et al 2016 , Rafiei et al 2018 , Ricci et al 2018 , Fitriakusumah et al 2019 , Ghosh and Jesudian 2019 , Wu et al 2019 , Phyo et al 2021 , Shah 2021 , Feng and Li 2022 , Ghoshal et al 2022 ), and other nongastrointestinal (or indirectly linked) diseases such as Parkinson’s and Alzheimer’s disease (Kuang et al 2021 , Kowalski and Mulak 2022 ).…”

Section: Disruption Of Small Intestinal Homeostasis In Nutrient Balancementioning

confidence: 99%

The small intestine: dining table of host–microbiota meetings

Delbaere

Roegiers

Bron

et al. 2023

FEMS Microbiology Reviews

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Growing evidence suggests the importance of the small intestinal bacteria in the diet-host-microbiota dialogue in various facets of health and disease. Yet, this body site is still poorly explored and its ecology and mechanisms of interaction with the host are just starting to be unraveled. In this review, we describe the current knowledge on the small intestinal ecology, its composition and diversity, and how the intestinal bacteria in homeostatic conditions participate in nutrient digestion and absorption. We illustrate the importance of a controlled bacterial density and of the preservation of absorptive surface for the host's nutritional status. In particular, we discuss these aspects of the small intestinal environment in the framework of two disease conditions, namely small intestinal bacterial overgrowth (SIBO) and short bowel syndrome (SBS). We also detail in vivo, ex vivo and in vitro models developed to simulate the small intestinal environment, some applied for (diet-)host-bacteria interaction studies. Lastly, we highlight recent technological, medical and scientific advances applicable to investigate this complex and yet understudied body environment to broaden our knowledge in support of further progress in the medical practice, and to proceed towards the integration of the (small)intestinal bacteria in personalized therapeutic approaches.

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