Breathing control, brain, and bodily self-consciousness: Toward immersive digiceuticals to alleviate respiratory suffering

Betka, Sophie; Adler, Dan; Similowski, Thomas; Blanke, Olaf

doi:10.1016/j.biopsycho.2022.108329

Cited by 24 publications

(19 citation statements)

References 248 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alternatively, some of the observed modulations could also be linked to mechanoreceptors in the chest wall whose projections appear to play a role in shaping respiratory sensations (Homma et al, 1988). Finally, basal ganglia and thalamus activity have also been common findings in neuroimaging studies of volitional breathing as well as investigating complex behavioral breathing acts, such as breathing during speech, while singing or exercising (Betka et al, 2022; McKay et al, 2003; K. Murphy et al, 1997; K. T. S. Pattinson, Governo, et al, 2009; K.…”

Section: Discussionmentioning

confidence: 99%

“…HEP has been linked with cardiac function (MacKinnon et al, 2013; Schandry & Montoya, 1996), but also with various cognitive and affective processes (Gray et al, 2007; Montoya et al, 1993; Park et al, 2014, 2016, 2018; Pollatos & Schandry, 2004; Schandry et al, 1986; Shao et al, 2011; Solcà et al, 2020). Although less investigated than cardiac signals, respiratory signals have also been shown to modulate brain oscillations at rest in widespread brain networks (Betka et al, 2022; Kluger & Gross, 2021). Similarly to cardiac signals, respiration has also been shown to influence a range of cognitive and motor processes (Adler et al, 2014; Allard et al, 2017; Kluger et al, 2021; Park et al, 2020; Perl et al, 2019; Rassler & Raabe, 2003; Schulz et al, 2016; Zelano et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Single neurons in thalamus and subthalamic nucleus process cardiac and respiratory signals in humans

Falco

Solcà

Bernasconi

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Visceral signals are constantly processed by our central nervous system, enable homeostatic regulation, and influence perception, emotion, and cognition. While visceral processes at cortical level have been extensively studied using non-invasive imaging techniques, very few studies have investigated how this information is processed at the single neuron level, both in humans and animals. Subcortical regions, relaying signals from peripheral interoceptors to cortical structures, are particularly understudied and how visceral information is processed in thalamic and subthalamic structures remains largely unknown. Here, we took advantage of intraoperative microelectrode recordings in patients undergoing surgery for deep brain stimulation (DBS) to investigate the activity of single neurons related to cardiac and respiratory functions in three subcortical regions: Ventral Intermedius nucleus (Vim) and Ventral caudalis nucleus (Vc) of the thalamus, and subthalamic nucleus (STN). We report that the activity of a large portion of the recorded neurons (about 70%) was modulated by either the heartbeat, the cardiac inter-beat interval, or the respiration. These cardiac and respiratory response patterns varied largely across neurons both in terms of timing and their kind of modulation. We observed neurons with increases or decreases in firing rate in response to either the heartbeat or the inter-beat interval. Peaks of neural activity were found at different phases of the cardiac and respiratory cycles. Whereas most neurons only responded to one of the tested signals, a substantial proportion of these visceral neurons (30%) was responsive to more than one of the tested signals, underlining specialization and integration of cardiac and respiratory signals in STN and thalamic neurons. By extensively describing for the first time single unit activity related to cardiorespiratory function in thalamic and subthalamic neurons, our results highlight the major role of these subcortical regions in the processing of visceral signals.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Single neurons in thalamus and subthalamic nucleus process cardiac and respiratory signals in humans

Falco

Solcà

Bernasconi

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Alle Menschen befinden sich vielmehr in einer Anpassung an äußere und innere Bedingungen, die an der Art, wie sie atmen (wie tief oder oberflächlich, wie schnell oder langsam, wie rhythmisch oder unrhythmisch), erkennbar ist. Diese Anpassung wird als Atemmuster (Breathing Pattern) bezeichnet 2 4 7 25 .…”

Section: Rhythmische Bewegung Des Atemsunclassified

“…Dies kann auf Dauer zu einer ungenügenden Regulierungsfähigkeit, z. B. adäquat auf physische und/oder psychische Belastung reagieren zu können, führen 2 23 27 29 30 34 44 . So kann ein Patient, der mit einem LWS-Syndrom und einem Mundatmungssyndrom in die osteopathische Praxis kommt, durch seine Reaktionsweise auffallen: Die Person verhält sich u.U.…”

Section: Folgen Des Mundatmungssyndromsunclassified

Das Mundatmungssyndrom in der osteopathischen Praxis

Keller,

Brümmer,

Schulz

2024

DO - Deutsche Zeitschrift für Osteopathie

View full text Add to dashboard Cite

Die Atmung wirkt sich auf die motorische Kontrolle und die Haltungsstabilität aus. Erklärt werden im folgenden Artikel der Begriff des Atemmusters und die Auswirkung des dysfunktionalen Atemmusters Mundatmungssyndrom auf die Haltung. Diese Haltungsanpassung wird mit ihren Auswirkungen auf die Atemmuskeln beschrieben. Um dieses Krankheitsbild besser zu verstehen, wird auf ihre pathologische Emotionsregulierung eingegangen. Zuletzt wird ein osteopathischer Therapieansatz vorgestellt.

show abstract

“…20 HRV is regulated in part by respiratory rate. 21,22 Different respiratory patterns have been associated with increased sympathetic (e.g., hyperventilation) or parasympathetic stimulation (e.g., slow, "deep" diaphragmatic breathing). 23 In turn, these different respiratory patterns can modify gas exchange, intracellular cascades, 24,25 and brain activity, 26 which can further influence other components of the ANS, including heart rate and HRV, in a feedback loop.…”

Section: Introductionmentioning

confidence: 99%

A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder: Des antécédents de tentatives de suicide dans le trouble bipolaire sont associés à une activation sympathique accrue dans le trouble bipolaire

et al. 2023

View full text Add to dashboard Cite

Objective Suicide risk in bipolar disorder (BD) is estimated to be up to 20 times higher than in the general population. While there is a large body of evidence suggesting that increased sympathetic activation is associated with disease and death, there is a paucity of research on the role of autonomic nervous system (ANS) dysfunction in patients with BD who have attempted suicide. Methods Fifty-three participants with BD used a wearable device to assess the association between history of suicide attempt, current suicidal ideation, and ANS dysfunction, including measures of heart rate variability (HRV) and respiratory rate. Data were analyzed in a series of unadjusted and adjusted bivariate models of association controlling for relevant variables. Results A history of suicide attempts was significantly associated with an increase in respiratory rate ( p < 0.01). These results remained significant after adjusting for age, BMI, and current mood state. There was no association between current suicidal ideation and heart rate or respiratory rate. In the frequency domain, HRV parameters suggest reduced parasympathetic (i.e., vagal) activity in participants with a history of suicide attempts and in those with current suicidality, suggesting changes in sympathicovagal balance in BD. Conclusions Our results suggest that changes in the ANS in patients with BD and a history of suicide attempt are not restricted to pure vagally mediated HRV parameters, but rather signal a general ANS dysregulation. This ANS imbalance may be contributing to illness burden and cardiovascular disease. Further research on the relationship between ANS and suicidality in BD is needed.

show abstract

Breathing control, brain, and bodily self-consciousness: Toward immersive digiceuticals to alleviate respiratory suffering

Cited by 24 publications

References 248 publications

Single neurons in thalamus and subthalamic nucleus process cardiac and respiratory signals in humans

Single neurons in thalamus and subthalamic nucleus process cardiac and respiratory signals in humans

Das Mundatmungssyndrom in der osteopathischen Praxis

A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder: Des antécédents de tentatives de suicide dans le trouble bipolaire sont associés à une activation sympathique accrue dans le trouble bipolaire

Contact Info

Product

Resources

About