“…In contrast, the BTS/ACPRC recommendations are based on several high and moderate quality controlled trials, among other original studies (Figure, Supplemental Tables S1 and S2), as well as on two Cochrane reviews (18,19) and two other systematic reviews of RCTs (17,34) (Supplemental Tables S3 and S4). The search strategy reported in the GINA document was limited to PubMed, while the authors of the BTS/ ACPRC guideline used a comprehensive search strategy and, what is more, the papers not included in the GINA guidelines were actually indexed in PubMed.…”