Aim To develop and validate an evidence-based home PLB intervention protocol for improving related health outcomes (e.g. dyspnea, exercise capability, etc.) in COPD patients and to present a detailed intervention development process. Methods Phase one of the Medical Research Council Framework for Developing and Evaluating Complex Interventions was employed to guide the development process of the PLB intervention. The appropriateness of the PLB protocol was finally determined by a panel of experts using the content validity index. Results The preliminary PLB intervention protocol was developed based on several underlying rationales, which encompass the extension of expiration time, enhancement of respiratory muscle strength, augmentation of tidal volume, and integration of the most reliable research evidence obtained from four systematic reviews, six RCTs, five clinical trials, and ten recommendations. The PLB intervention was structured with a designated time ratio of inspiration to expiration, set at 1:2. Additionally, the training parameters of the PLB intervention were established as follows: three sessions per day, each lasting for 10 minutes, over a duration of 8 weeks. The intensity of PLB training was individualized, with the inhalation component adjusted according to each participant's tolerance level, while emphasizing the exhalation phase to ensure complete expulsion of air from the lungs. Regarding the content validity of the PLB intervention protocol, it demonstrated excellence, as consensus was achieved among all panel experts. Both the item-level and scale-level Content Validity Indices (CVIs) reached the maximum score of 1.0, indicating a high level of agreement and credibility in the content of the protocol as evaluated by the expert panel. Conclusion An optimal evidence-based home PLB protocol has been adapted and developed to manage COPD patients' health-related outcomes. The protocol is transparent and fully supported by relevant mechanisms, concrete evidence, recommendations, and expert consensus.