Breathing manoeuvre-dependent changes in myocardial oxygenation in healthy humans

Guensch, Dominik P.; Fischer, Kady; Flewitt, Jacqueline; Yu, Janelle; Lukic, Ryan; Friedrich, Julian A; Friedrich, Matthias G.

doi:10.1093/ehjci/jet171

Cited by 35 publications

(47 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several recent studies have used OS-CMR to monitor changes of myocardial oxygenation after changing blood gas levels, especially O 2 and CO 2 . 3,10,11,30 Those studies showed that OS-CMR is a reliable tool to assess the impact of hyperoxia on myocardial oxygenation. 31 Coronary artery stenosis in our animals was verified by an FFR of <0.75.…”

Section: Downloaded From Hyperoxia Worsens Myocardial Ischemiamentioning

confidence: 99%

See 1 more Smart Citation

Hyperoxia Exacerbates Myocardial Ischemia in the Presence of Acute Coronary Artery Stenosis in Swine

Guensch

Fischer

Shie

et al. 2015

Circ: Cardiovascular Interventions

View full text Add to dashboard Cite

Background-Current guidelines limit the use of high oxygen tension after return of spontaneous circulation after cardiac arrest, focusing on neurological outcome and mortality. Little is known about the impact of hyperoxia on the ischemic heart. Oxygen is frequently administered and is generally expected to be beneficial. This study seeks to assess the effects of hyperoxia on myocardia oxygenation in the presence of severe coronary artery stenosis in swine. Methods and Results-In 22 healthy pigs, we surgically attached a magnetic resonance compatible flow probe to the left anterior descending coronary artery (LAD). In 11 pigs, a hydraulic occluder was inflated distal to the flow probe. After increasing PaO 2 to >300 mm Hg, LAD flow decreased in all animals. In 8 stenosed animals with a mean fractional flow reserve of 0.64±0.02, hyperoxia resulted in a significant decrease of myocardial signal intensity in oxygenationsensitive cardiovascular magnetic resonance images of the midapical segments of the LAD territory. This was not seen in remote myocardium or in the other 8 healthy animals. The decreased signal intensity was accompanied by a decrease in circumferential strain in the same segments. Furthermore, ejection fraction, cardiac output, and oxygen extraction ratio declined in these animals. Changing PaCO 2 levels did not have a significant effect on any of the parameters; however, hypercapnia seemed to nonsignificantly attenuate the hyperoxia-induced changes. Conclusions-Ventilation-induced hyperoxia may decrease myocardial oxygenation and lead to ischemia in myocardium subject to severe coronary artery stenosis. (Circ Cardiovasc Interv. 2015;8:e002928.

show abstract

Section: Downloaded From Hyperoxia Worsens Myocardial Ischemiamentioning

confidence: 99%

“…It has been shown that it can detect changes in myocardial oxygenation triggered by systemic changes of blood gases, that is, oxygen and carbon dioxide. 10,11 The purpose of this study was to investigate the effect of hyperoxia on myocardial oxygenation and myocardial…”

mentioning

confidence: 99%

Hyperoxia Exacerbates Myocardial Ischemia in the Presence of Acute Coronary Artery Stenosis in Swine

Guensch

Fischer

Shie

et al. 2015

Circ: Cardiovascular Interventions

View full text Add to dashboard Cite

show abstract

“…By exploiting the blood oxygenation level-dependent (BOLD) effect [3], T 2 * sensitized CMR has been proposed as a means of assessing myocardial tissue oxygenation and perfusion. T 2 * mapping has been shown to be capable of detecting myocardial ischemia caused by coronary artery stenosis [4], to reveal myocardial perfusion deficits under pharmacological stress [5][6][7][8][9][10], to study endothelial function [11] or to assess breathing maneuver-dependent oxygenation changes in the myocardium [12][13][14][15]. Preclinical studies have also demonstrated the potential of T 2 * mapping to detect structural changes in the infarcted heart muscle and even to distinguish between focal and diffuse fibrosis [16][17][18].…”

Section: T 2 * Sensitized Cardiovascular Magnetic Resonancementioning

confidence: 99%

Myocardial T2* Mapping with Ultrahigh Field Magnetic Resonance: Physics and Frontier Applications

Huelnhagen

Paul

et al. 2017

Front. Phys.

View full text Add to dashboard Cite

Cardiovascular magnetic resonance imaging (CMR) has become an indispensable clinical tool for the assessment of morphology, function and structure of the heart muscle. By exploiting quantification of the effective transverse relaxation time (T 2 * ) CMR also affords myocardial tissue characterization and probing of cardiac physiology, both being in the focus of ongoing research. These developments are fueled by the move to ultrahigh magnetic field strengths, which permits enhanced sensitivity and spatial resolution that help to overcome limitations of current clinical MR systems with the goal to contribute to a better understanding of myocardial (patho)physiology in vivo. In this context, the aim of this report is to introduce myocardial T 2 * mapping at ultrahigh magnetic fields as a promising technique to non-invasively assess myocardial (patho)physiology. For this purpose the basic principles of T 2 * assessment, the biophysical mechanisms determining T 2 * and (pre)clinical applications of myocardial T 2 * mapping are presented.Technological challenges and solutions for T 2 * sensitized CMR at ultrahigh magnetic field strengths are discussed followed by a review of acquisition techniques and post-processing approaches. Preliminary results derived from myocardial T 2 * mapping in healthy subjects and cardiac patients at 7.0 T are presented. A concluding section discusses remaining questions and challenges and provides an outlook on future developments and potential clinical applications.

show abstract

“…Breathing maneuvers have been proposed as a physiological vasoactive stimulus leading to consistent myocardial signal intensity changes in oxygenation-sensitive MR images [8,[20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

“…Mostly related to changes in blood carbon dioxide (CO 2 ), a breath-hold (leading to hypercapnia with a net increase of blood CO 2 ) is an effective vasodilator, whereas hyperventilation with hypocapnia causes vasoconstriction [8,[20][21][22]. By combining these maneuvers, the achievable changes in pCO 2 are increased, resulting in a more extended range in vascular resistance with greater changes in OS signal intensity Because of an abnormal coronary vascular response in patients with OSAS, we hypothesized that the coronary vascular response to hyperventilation and long breath-hold is diminished in patients with OSAS when compared to healthy volunteers, as reflected by changes in myocardial oxygenation during voluntary apnea following hyperventilation.…”

Section: Introductionmentioning

confidence: 99%

Impact of hyperventilation and apnea on myocardial oxygenation in patients with obstructive sleep apnea – An oxygenation-sensitive CMR study

Roubille

Fischer

Guensch

et al. 2017

Journal of Cardiology

View full text Add to dashboard Cite

show abstract

Breathing manoeuvre-dependent changes in myocardial oxygenation in healthy humans

Abstract: In healthy individuals, breathing manoeuvres lead to changes in myocardial oxygenation, which appear to be mediated by CO₂. These changes can be monitored in vivo by oxygenation-sensitive CMR and thus, may have value as a diagnostic tool.

Cited by 35 publications

References 24 publications

Hyperoxia Exacerbates Myocardial Ischemia in the Presence of Acute Coronary Artery Stenosis in Swine

Hyperoxia Exacerbates Myocardial Ischemia in the Presence of Acute Coronary Artery Stenosis in Swine

Myocardial T2* Mapping with Ultrahigh Field Magnetic Resonance: Physics and Frontier Applications

Impact of hyperventilation and apnea on myocardial oxygenation in patients with obstructive sleep apnea – An oxygenation-sensitive CMR study

Contact Info

Product

Resources

About