Breathlessness with Pleural Effusion: What Do We Know?

Muruganandan, Sanjeevan; Mishra, Eleanor; Singh, Bhajan

doi:10.1055/s-0043-1769098

Cited by 6 publications

(3 citation statements)

References 56 publications

(95 reference statements)

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“…Coughing, expectoration, chest tightness, and shortness of breath collectively constitute the respiratory SC. Lung tumors or pleural effusion can result in airway obstruction, contributing to manifestations such as coughing, chest tightness, and shortness of breath [ 47 ]. Additionally, chemotherapy medications can induce systemic inflammation, resulting in congestion of the respiratory mucosa and increased production of secretions [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of symptom clusters and sentinel symptoms during the first cycle of chemotherapy in patients with lung cancer

Luo,

Mao,

Zhang

et al. 2024

Support Care Cancer

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Purpose To identify symptom clusters (SCs) in patients with lung cancer who are undergoing initial chemotherapy and to identify the sentinel symptoms of each SC. Methods A convenience sampling method was used to recruit patients with lung cancer who were undergoing their initial chemotherapy treatment. Patient information was collected using the General Demographic Questionnaire, MD Anderson Symptom Inventory (including the lung cancer module) and a schedule documenting the initial occurrence of symptoms. The Walktrap algorithm was employed to identify SCs, while sentinel symptoms within each SC were identified using the Apriori algorithm in conjunction with the initial occurrence time of symptoms. Results A total of 169 patients with lung cancer participated in this study, and four SCs were identified: the psychological SC (difficulty remembering, sadness, dry mouth, numbness or tingling, and distress), somatic SC (pain, fatigue, sleep disturbance, and drowsiness), respiratory SC (coughing, expectoration, chest tightness, and shortness of breath), and digestive SC (nausea, poor appetite, constipation, vomiting, and weight loss). Sadness, fatigue, and coughing were identified as sentinel symptoms of the psychological, somatic, and respiratory SCs, respectively. However, no sentinel symptom was identified for the digestive SC. Conclusion Patients with lung cancer who are undergoing chemotherapy encounter a spectrum of symptoms, often presenting as SCs. The sentinel symptom of each SC emerges earlier than the other symptoms and is characterized by its sensitivity, significance, and driving force. It serves as a vital indicator of the SC and assumes a sentry role. Targeting sentinel symptoms might be a promising strategy for determining the optimal timing of interventions and for mitigating or decelerating the progression of the other symptoms within the SC.

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Section: Discussionmentioning

confidence: 99%

Identification of symptom clusters and sentinel symptoms during the first cycle of chemotherapy in patients with lung cancer

Luo,

Mao,

Zhang

et al. 2024

Support Care Cancer

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“…In the presence of adhesions, unfortunately, we do not have clear indications about the possible symptoms, and we do not have a gold standard of manual treatment. We know that the presence of pleural effusion pushes the corresponding portion of the diaphragm downwards, while thoracentesis helps diaphragmatic repositioning [21]. Probably, a possible concomitant lesion of the phrenic nerve (not evaluated), and the presence of visceral mediastinal adhesions, could have facilitated the cranial movement of the diaphragm muscle.…”

Section: Discussionmentioning

confidence: 99%

Pericardial Adhesion and Chronic Non-Specific Neck Pain following Thoracentesis: An Osteopathic Approach

Bordoni,

Escher

2023

Clinics and Practice

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Cardiovascular diseases (CVDs) are the leading cause of death globally. Morbidity and disability related to non-fatal events are increasing exponentially. There are several symptoms that may arise after invasive therapeutic approaches such as coronary artery bypass graft (CABG), including chronic pain in anatomical areas connected to the mediastinum; these pains can be found not only initially after surgery but also years later. We present a case where non-specific neck pain (NNP), in a patient undergoing CABG five years earlier, was resolved with an osteopathic technique, working the pericardial area. To the knowledge of the authors, it is the first article illustrating an osteopathic approach with resolution of NNP, with a manual technique used on the pericardial area.

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“…Muruganandan et al highlight the new advances in our understanding of why patients with pleural effusion are breathless, which is of significant interest to clinicians. 11 Indwelling pleural catheters (IPCs) are now an established management of recurrent, especially malignant, pleural effusions. The focus of research has shifted from their advantages to how best to manage, or prevent, complications of IPC use.…”

mentioning

confidence: 99%