Breed‐associated variability in serum biochemical analytes in four large‐breed dogs

Sharkey, Leslie C.; Gjevre, Karen; Hegstad-Davies, Rebecca L.; Torres, Sheila M. F.; Muñoz-Zanzi, Claudia

doi:10.1111/j.1939-165x.2009.00134.x

Cited by 22 publications

(20 citation statements)

References 24 publications

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“…Lastly, the effect Data are presented as mean ± 95% Confidence Interval of dog breed on our values has not been factored. It has been reported that reference values for some biochemical parameters differ between dog breeds (Sharkey et al 2009;Mori et al 2010;Nielsen et al 2010). As such, it is important to consider breed during analysis.…”

Section: Discussionmentioning

confidence: 97%

Age-specific plasma biochemistry reference ranges in <1 year old dogs in Japan

et al. 2011

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The purpose of this study was to investigate and propose possible reference intervals of plasma biochemical analytes in young dogs (<12 months old) in Japan, using 896 canine plasma samples, collected from an array of veterinary clinics throughout the greater Tokyo metropolis area in Japan. The following biochemical parameters were assessed: albumin (ALB), alanine aminotransferase (ALT), alkaline phosphatase (ALP), amylase, aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (CRE), glucose, lipase, total cholesterol (T-Cho), and total protein (TP) were evaluated. Multivariate linear regression analysis indicated that partitioning according to age or gender may be necessary for some plasma analytes. Age appeared to significantly affect ALB, ALT, ALP, BUN, Glucose, Lipase, and Total Protein (P= <0.001, <0.001, <0.001, 0.013, <0.001, 0.025, and <0.001, respectively). On the other hand, gender significantly influenced ALP, Amylase, Lipase, and T-Cho levels (P=0.017, <0.001, <0.001, and <0.001, respectively) whereas it may be borderline significant with ALT (P=0.072).

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Section: Discussionmentioning

confidence: 97%

Age-specific plasma biochemistry reference ranges in <1 year old dogs in Japan

et al. 2011

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“…Selection of a suitable and adequate reference sample group, representative of the canine species, is crucial. In addition, breed‐specific RIs for certain particular breeds might be useful for avoiding erroneous clinical decisions, as has been reported for Greyhounds, Lurchers, Bernese Mountain Dogs, and other large breeds in clinical pathology …”

Section: Introductionmentioning

confidence: 99%

Breed‐specific hematologic reference intervals in healthy adult Dogues de Bordeaux

Lavoué

Geffré

et al. 2014

Veterinary Clinical Pathol

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The generic canine RIs established in the same laboratory with analogous preanalytical and analytical variations did not differ significantly from breed-specific RIs, and thus have no significant impact on clinical decision making; however, breed-specific RIs are advised for some RBC and all platelet-related variables to avoid erroneous suspicion of polycythemia and thrombocytopenia when using general canine RIs for evaluation of DDB.

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“…Reference intervals are used in veterinary medicine to help classify laboratory results reflecting either healthy or diseased animals. Although breed‐specific reference intervals have received little attention in the literature, it is recognised that some breeds have biochemistry variables that differ sufficiently to justify breed‐specific reference intervals (Vondruska and Greco 1974, Sharkey and others 2009). Biochemistry results for greyhounds have been previously evaluated and reference intervals determined with relatively small sample sizes: Steiss and others (2000) n=50; Porter and Canaday (1971) divided sample numbers into males n=22 to 24 and females n=21 to 25; Feeman and others (2003) n=30.…”

Section: Introductionmentioning

confidence: 99%

Determination of serum biochemistry reference intervals in a large sample of adult greyhounds

Dunlop

Sánchez-Vázquez

Freeman

et al. 2010

J of Small Animal Practice

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Total protein, albumin, globulin and creatinine reference intervals differed from generic reference intervals used for dogs. The reference intervals for greyhounds in this study are similar to those obtained by other studies of greyhounds, but often had a narrower range of values, likely reflecting more accurate estimation associated with larger numbers of reference individuals. Recommended methods for assessment of partitioning do not indicate a need to partition according to gender.

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Breed‐associated variability in serum biochemical analytes in four large‐breed dogs

Abstract: Although many statistically significant breed-related differences in serum biochemical values were observed, the differences were small and unlikely to have clinical relevance or impact medical decision making.

Cited by 22 publications

References 24 publications

Age-specific plasma biochemistry reference ranges in <1 year old dogs in Japan

Age-specific plasma biochemistry reference ranges in <1 year old dogs in Japan

Breed‐specific hematologic reference intervals in healthy adult Dogues de Bordeaux

Determination of serum biochemistry reference intervals in a large sample of adult greyhounds

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