Brennnesseltrockenextrakt (Bazoton � -uno) in der Langzeittherapie des benignen Prostatasyndroms (BPS)

Abstract

Phytotherapy of BPS has a long tradition in Germany; nevertheless, data referring to single phytotherapeutic agents are rare. We therefore performed a randomized, double-blind, placebo-controlled multicenter study for 1 year with Bazoton uno (459 mg dry extract of stinging nettle roots) with 246 patients. The IPSS decreased on average from 18.7+/-0.3 to 13.0+/-0.5 with a statistically significant difference compared to placebo (18.5+/-0.3 to 13.8+/-0.5; p=0.0233). The median Q(max) increased by 3.0+/-0.4 ml/s in comparison to 2.9+/-0.4 ml/s (placebo), thus not statistically significantly different, as well as the median volume of residual urine, which changed from 35.5+/-3.4 ml before therapy to 20.0+/-2.8 ml and from 40.0+/-4.0 ml to 21.0+/-2.9 ml under placebo application. The number of adverse events (29/38) as well as urinary infections etc. (3/10 events) was smaller under Bazoton uno therapy compared to placebo. Treatment with Bazoton uno can therefore be considered a safe therapeutic option for BPS, especially for reducing irritative symptoms and BPS-associated complications due to the postulated antiphlogistic and antiproliferative effects of the stinging nettle extract. A strong increase of Q(max) or reduction of residual urine are not to be expected.

Effects of Pumpkin Seed in Men with Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia in the One-Year, Randomized, Placebo-Controlled GRANU Study

“…This response exceeds the rate of 43% reported by patients treated with herbal medicines in real-life practice in the TRIUMPH study [22]. The average IPSS reduction of 5.8 points that was achieved with pumpkin seed in the present study exceeds the placebo result by 1.4 points, whereas in studies of other herbal preparations, only a 1-point difference from placebo was observed [16,23]. The post-/pre-treatment ratio of 0.66 for the IPSS in the pumpkin seed group represents a fair response and almost reaches the level of 0.6 indicating a good response according to the efficacy grading of the International Consultation on BPH [24].…”

Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients with Croton membranaceus Ethanolic Root Extract

“…A few monoherbal plants have reduced IPSS. These include Serenoa repens Bartram [ 34 ], Urtica dioica L. [ 27 ], and Pteris multifida [ 28 ]. In the present study C. membranaceus ethanolic root extract (a monoherbal preparation) showed a significant reduction in total IPSS of the subjects at the end of the study period ( P = 0.001).…”

Management of Benign Prostatic Hyperplasia: Could Dietary Polyphenols Be an Alternative to Existing Therapies?

“…Other clinical studies carried out supported the use of phytotherapies from different plants such as Eviprostat (Matsumoto et al, 2010), Pygeum africanum extract (Chatelain et al, 1999), Stinging nettle root extract (Bazotonuno) (Schneider and Rübben, 2004), PR-2000 ( Tribulus terrestris ) (Sahu and Kumar, 2001), and others in the management of BPH but which are beyond the scope of this review as the actual polyphenols in these phytotherapies were not indicated in these studies.…”